Clifford Lowell, MD, PhD

Professor
Laboratory Medicine
+1 415 476-2963

Clifford Lowell, MD, PhD studies the role of Src family kinases and the Syk tyrosine kinase in signal transduction pathways within hematopoietic cells.

Publications: 

Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury.

The Journal of clinical investigation

Moussavi-Harami SF, Cleary SJ, Magnen M, Seo Y, Conrad C, English BC, Qiu L, Wang KM, Abram CL, Lowell CA, Looney MR

TLR Engagement Induces an Alternate Pathway for BCR Signaling that Results in PKCδ Phosphorylation.

Journal of immunology (Baltimore, Md. : 1950)

Khan N, Hu Y, Lowell CA, Rothstein TL

Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury.

bioRxiv : the preprint server for biology

Moussavi-Harami SF, Cleary SJ, Magnen M, Seo Y, Conrad C, English BC, Qiu L, Wang KM, Abram CL, Lowell CA, Looney MR

Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection.

Journal of immunology (Baltimore, Md. : 1950)

Kamen LA, Schlessinger J, Lowell CA

Insights from CTTACC: immune system reset by cellular therapies for chronic illness after trauma, infection, and burn.

Cytotherapy

Bertram K, Cox C, Alam H, Lowell C, Cuschieri J, Parekkadan B, Pati S

Validation of a murine proteome-wide phage display library for identification of autoantibody specificities.

JCI insight

Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu DJ, Zamecnik CR, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, DeRisi JL

Thrombopoietin levels in sepsis and septic shock - a systematic review and meta-analysis.

Clinical chemistry and laboratory medicine

Liu C, Görlich D, Lowell CA, Italiano JE, Rossaint J, Bender M, Zarbock A, Margraf A

Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models.

The Journal of experimental medicine

Futosi K, Németh T, Horváth ÁI, Abram CL, Tusnády S, Lowell CA, Helyes Z, Mócsai A

Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities.

bioRxiv : the preprint server for biology

Rackaityte E, Proekt I, Miller HS, Ramesh A, Brooks JF, Kung AF, Mandel-Brehm C, Yu D, Zamecnik C, Bair R, Vazquez SE, Sunshine S, Abram CL, Lowell CA, Rizzuto G, Wilson MR, Zikherman J, Anderson MS, DeRisi JL

NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases.

The American journal of pathology

Hu C, Priceputu E, Cool M, Chrobak P, Bouchard N, Forestier C, Lowell CA, Bénichou S, Hanna Z, Royal V, Jolicoeur P

Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis.

Frontiers in immunology

Costa S, Bevilacqua D, Caveggion E, Gasperini S, Zenaro E, Pettinella F, Donini M, Dusi S, Constantin G, Lonardi S, Vermi W, De Sanctis F, Ugel S, Cestari T, Abram CL, Lowell CA, Rodegher P, Tagliaro F, Girolomoni G, Cassatella MA, Scapini P

Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells.

JCI insight

Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, Spieker T, Tekath T, Velic A, Holtmeier R, Hermann J, Jankowski V, Meersch M, Vestweber D, Westphal M, Roth J, Schäfers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A

Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.

Cell reports

Poh AR, O'Brien M, Chisanga D, He H, Baloyan D, Traichel J, Dijkstra C, Chopin M, Nutt S, Whitehead L, Boon L, Parkin A, Lowell C, Pajic M, Shi W, Nikfarjam M, Ernst M

Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.

Science advances

Poh AR, Love CG, Chisanga D, Steer JH, Baloyan D, Chopin M, Nutt S, Rautela J, Huntington ND, Etemadi N, O'Brien M, O'Keefe R, Ellies LG, Macri C, Mintern JD, Whitehead L, Gangadhara G, Boon L, Chand AL, Lowell CA, Shi W, Pixley FJ, Ernst M

Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection.

The Journal of Immunology

Mianmian Yin, Jennifer A Smith, Marissa Chou, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco

Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells.

The Journal of Immunology

Mianmian Yin, Kamir J Hiam, Irina Proekt, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Matthew Spitzer, Mark S Anderson, Anthony L DeFranco

A dominant function of LynB kinase in preventing autoimmunity.

Science advances

Brian BF, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS

Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury.

Journal of neuroinflammation

McCreedy DA, Abram CL, Hu Y, Min SW, Platt ME, Kirchhoff MA, Reid SK, Jalufka FL, Lowell CA

Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment.

Blood

Hua-Xin Gao, Eleanor Fraser, Mario Merlini, Huimin Geng, Lingjing Chen, Ming Lu, Yasmin Moshfegh, Joseph Cleveland, Jae Ryu, Jigyasa Sharma, David A. Solomon, Katerina Akassoglou, Clifford Lowell, James L. Rubenstein

Signal Integration by Translocation and Phosphorylation of PKCδ in the B Cell Alternate Pathway.

Journal of immunology (Baltimore, Md. : 1950)

Khan N, Hu Y, Lowell CA, Rothstein TL

HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels.

Journal of virology

Priceputu E, Cool M, Bouchard N, Caceres-Cortes JR, Lowell CA, Hanna Z, Jolicoeur P

Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation.

Diabetes care

Rutsch N, Chamberlain CE, Dixon W, Spector L, Letourneau-Freiberg LR, Lwin WW, Philipson LH, Zarbock A, Saintus K, Wang J, German MS, Anderson MS, Lowell CA

1126-P: Activating SKAP2 Mutation Linked to Diabetes with Multiple Autoimmune and Inflammatory Conditions.

Diabetes

CHESTER CHAMBERLAIN, NIKLAS RUTSCH, WESLEY DIXON, LISA R. LETOURNEAU-FREIBERG, LOUIS H. PHILIPSON, MICHAEL GERMAN, MARK S. ANDERSON, CLIFFORD A. LOWELL

Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling.

Cell reports

Okubo K, Brenner MD, Cullere X, Saggu G, Patchen ML, Bose N, Mihori S, Yuan Z, Lowell CA, Zhu C, Mayadas TN

A CD22-Shp1 phosphatase axis controls integrin ß 7 display and B cell function in mucosal immunity.

The FASEB Journal

Romain Ballet, Martin Brennan, Carolin Brandl, Ningguo Feng, Jeremy Berri, Julian Cheng, Borja Ocón, Amin Alborzian Deh Sheikh, Alex Marki, Yuhan Bi, Clare Abram, Clifford Lowell, Takeshi Tsubata, Harry Greenberg, Matthew Macauley, Klaus Ley, Lars Nitschke, Eugene Butcher

Correlation of autoantigen-specific Treg frequency with development of spontaneous organ-specific autoimmunity in a mouse model of uveitis.

The Journal of Immunology

Mianmian Yin, Kamir Hiam, Irina Proekt, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco

T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement.

The Journal of Immunology

Mianmian Yin, Jennifer A Smith, Marissa Chou, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco

A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity.

Nature immunology

Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocón B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC

A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.

American journal of physiology. Lung cellular and molecular physiology

Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA

Complement activation on endothelium initiates antibody-mediated acute lung injury.

The Journal of clinical investigation

Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.

Frontiers in immunology

Myers DR, Abram CL, Wildes D, Belwafa A, Welsh AMN, Schulze CJ, Choy TJ, Nguyen T, Omaque N, Hu Y, Singh M, Hansen R, Goldsmith MA, Quintana E, Smith JAM, Lowell CA

ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense.

Proceedings of the National Academy of Sciences of the United States of America

Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA

The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.

Infection and immunity

Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE

Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.

Cancer immunology research

Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.

The Journal of clinical investigation

Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A

Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration.

Haematologica

Rohwedder I, Kurz ARM, Pruenster M, Immler R, Pick R, Eggersmann T, Klapproth S, Johnson JL, Alsina SM, Lowell CA, Mócsai A, Catz SD, Sperandio M

L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling.

Blood

Cappenberg A, Margraf A, Thomas K, Bardel B, McCreedy DA, Van Marck V, Mellmann A, Lowell CA, Zarbock A

Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis.

eNeuro

McCreedy DA, Lee S, Sontag CJ, Weinstein P, Olivas AD, Martinez AF, Fandel TM, Trivedi A, Lowell CA, Rosen SD, Noble-Haeusslein LJ

Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.

Blood advances

Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B

PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.

British journal of pharmacology

Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A

Neutrophils: Their Role in Innate and Adaptive Immunity 2017.

Journal of immunology research

Rosales C, Lowell CA, Schnoor M, Uribe-Querol E

B cell autoimmunity at the extremes.

Nature immunology

Zikherman J, Lowell CA

Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice.

American journal of respiratory cell and molecular biology

Sinha M, Lowell CA

Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.

Journal of leukocyte biology

Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P

Shp1 function in myeloid cells.

Journal of leukocyte biology

Abram CL, Lowell CA

Differentiating pulmonary transfusion reactions using recipient and transfusion factors.

Transfusion

Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group

SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.

Nature

Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.

Cancer cell

Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, Monard S, Khakham Y, Burstroem L, Lessene G, Sieber O, Lowell C, Putoczki TL, O'Donoghue RJJ, Ernst M

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.

The Journal of experimental medicine

Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A

Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.

PloS one

Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL

Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma.

Blood

Huimin Geng, Huaxin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Rana Anjum, Lisa Drew, Sebastien Degorce, Keith Dillman, Michele Mayo, Shawn Anderson, Colin Collins, Clifford A. Lowell, James L. Rubenstein

Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection.

Immunity

Iborra S, Martínez-López M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martín Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D

LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.

The Journal of clinical investigation

Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.

Journal of immunology (Baltimore, Md. : 1950)

Hang L, Blum AM, Kumar S, Urban JF, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

PLoS pathogens

Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M

Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.

American journal of respiratory cell and molecular biology

Sinha M, Lowell CA

Triggering of organ-specific autoimmunity through synergy of defects in key tolerance checkpoints.

The Journal of Immunology

Irina Proekt, Corey Miller, Marion Jeanne, Kayla Fasano, Clifford A Lowell, Douglas Gould, Mark S Anderson, Anthony L DeFranco

FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.

PLoS pathogens

Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV

Neutrophils in animal models of autoimmune disease.

Seminars in immunology

Németh T, Mócsai A, Lowell CA

Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Nature

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M

Abstract PR11: Targeted engagement of B cell autoimmunity checkpoints to overcome drug resistance in pediatric Ph-like ALL.

Targeted Therapeutics and Resistance

Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Stephen P. Hunger, Markus Müschen

Neutrophils: Their Role in Innate and Adaptive Immunity.

Journal of immunology research

Rosales C, Demaurex N, Lowell CA, Uribe-Querol E

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.

Immunity

Volmering S, Block H, Boras M, Lowell CA, Zarbock A

Integrins: Regulation of Adhesion and Downstream Signaling.

Encyclopedia of Immunobiology

Clifford A. Lowell

Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia.

Blood

Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

eLife

Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A

Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.

Immunity

Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG

Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice.

Shock (Augusta, Ga.)

Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J

Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia.

Molecular and cellular biology

Zhengshan Chen, Seyedmehdi Shojaee, Maike Buchner, Huimin Geng, Jae Woong Lee, Lars Klemm, Eugene Park, Ying Xim Tan, Anne Satterthwaite, Elisabeth Paietta, Stephen P. Hunger, Mignon L. Loh, Jae U. Jung, John E. Coligan, Silvia Bolland, Tak W. Mak, Andre Limnander, Hassan Jumaa, Michael Reth, Arthur Weiss, Clifford A. Lowell, Markus Müschen

The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.

Journal of immunology (Baltimore, Md. : 1950)

Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, Berton G

Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment.

Journal of immunology (Baltimore, Md. : 1950)

Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A

Intracellular signalling during neutrophil recruitment.

Cardiovascular research

Mócsai A, Walzog B, Lowell CA

Regulation of neutrophil cytokine production during inflammation (INC6P.319).

The Journal of Immunology

Jacques Deguine, Meenal Sinha, Clifford Lowell, Gregory Barton

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Nature

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M

A2.21 The role of HCK, FGR and LYN in in vivo inflammation in mice.

Annals of the Rheumatic Diseases

M Kovács, T Németh, Z Jakus, C Sitaru, E Simon, K Futosi, B Botz, Z Helyes, CA Lowell, A Mócsai

Store-operated calcium signaling in neutrophils.

Journal of leukocyte biology

Clemens RA, Lowell CA

Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

Transfusion

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group

Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Transfusion

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia.

Blood

Zhengshan Chen, Seyedmehdi Shojaee, Huimin Geng, Jae-Woong Lee, Maike Buchner, Lars Klemm, Clifford A. Lowell, Elisabeth Paietta, Cheryl L. Willman, William L. Carroll, Ari Melnick, Jae U. Jung, Hassan Jumaa, John E. Coligan, Silvia Bolland, Tak W. Mak, Markus Muschen

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

The Journal of experimental medicine

Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A

Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Critical care medicine

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P, Transfusion-Related Acute Lung Injury Study Group

Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering.

Developmental cell

Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell CA, Grinstein S

ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.

Cell metabolism

Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA

Molecular editing of cellular responses by the high-affinity receptor for IgE.

Science (New York, N.Y.)

Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, Lowell CA, Rivera J

STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.

Blood

Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA

Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Journal of immunology (Baltimore, Md. : 1950)

Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL

B cell-specific loss of Lyn kinase leads to autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Lamagna C, Hu Y, DeFranco AL, Lowell CA

Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia.

Blood

Zhengshan Chen, Seyedmehdi Shojaee, Huimin Geng, Jaewoong Lee, Maike Buchner, Lars Klemm, Clifford A. Lowell, Elisabeth Paietta, Cheryl L. Willman, William L. Carroll, Ari M. Melnick, Jae U. Jung, Hassan Jumaa, John E. Coligan, Silvia Bolland, Tak W. Mak, Markus Muschen

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy.

Blood

Hua-Xin Gao, Shawn Anderson, Cigall Kadoch, Mekhala Maiti, Lingjing Chen, Dong-Han Yao, Gerd Melkus, Maria Wang, Yan Ren, Michael Breider, Carla Heise, Clifford A. Lowell, Colin Collins, James L. Rubenstein

Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.

Blood

Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z

The multifaceted functions of neutrophils.

Annual review of pathology

Mayadas TN, Cullere X, Lowell CA

Neutrophils mediate antibody-induced antitumor effects in mice.

Blood

Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P

Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA

Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Vérollet C, Gallois A, Dacquin R, Lastrucci C, Pandruvada SN, Ortega N, Poincloux R, Behar A, Cougoule C, Lowell C, Al Saati T, Jurdic P, Maridonneau-Parini I

The roles of tumor associated macrophages and interferon gamma in immune surveillance in CNS lymphoma (P2211).

The Journal of Immunology

Hua-Xin Gao, Valerie Wong, Lingjing Chen, Richard Locksley, Clifford Lowell, James Rubenstein

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma.

Blood

Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C

Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.

Developmental cell

Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.

Blood

Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE

Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung.

Cell reports

Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

Journal of cell science

Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD

Distinct and overlapping functional roles of Src family kinases in mouse platelets.

Journal of thrombosis and haemostasis : JTH

Séverin S, Nash CA, Mori J, Zhao Y, Abram C, Lowell CA, Senis YA, Watson SP

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.

The Journal of experimental medicine

Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A

Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.

Anesthesia and analgesia

Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA

Establishment of a Novel System for Studying the Syk Function in B Cells.

Chembiomolecular Science

Tomohiro Kurosaki, Clifford A. Lowell

Overview: studying integrins in vivo.

Methods in molecular biology (Clifton, N.J.)

Lowell CA, Mayadas TN

B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.

Proceedings of the National Academy of Sciences of the United States of America

Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA

Transfusion-related acute lung injury: incidence and risk factors.

Blood

Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group

Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,.

Blood

Cigall Kadoch, Valerie Wong, Lingjing Chen, Anna Bet-Lachin, Ritu Roy, William Hyun, Caroline Behler, Clifford Lowell, James L. Rubenstein

Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,.

Blood

Hua-Xin Gao, Shawn Anderson, Lingjing Chen, Cigall Kadoch, Byron C Hann, Clifford Lowell, Colin Collins, James L. Rubenstein

Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa.

Journal of leukocyte biology

Xu X, Zhang H, Song Y, Lynch SV, Lowell CA, Wiener-Kronish JP, Caughey GH

Deletion of Syk in neutrophils prevents immune complex arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America

Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA

Critical role for Syk in responses to vascular injury.

Blood

Andre P, Morooka T, Sim D, Abe K, Lowell C, Nanda N, Delaney S, Siu G, Yan Y, Hollenbach S, Pandey A, Gao H, Wang Y, Nakajima K, Parikh SA, Shi C, Phillips D, Owen W, Sinha U, Simon DI

The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells.

Journal of immunology (Baltimore, Md. : 1950)

Guiet R, Van Goethem E, Cougoule C, Balor S, Valette A, Al Saati T, Lowell CA, Le Cabec V, Maridonneau-Parini I

Differential transformation capacity of Src family kinases during the initiation of prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America

Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON

BCAP negatively regulates TLR signaling in macrophages (116.13).

The Journal of Immunology

Minjian Ni, Alexander MacFarlane, Kerry Campbell, Clifford Lowell, Jessica Hamerman

Neutrophils give us a shock.

The Journal of clinical investigation

Lowell CA

IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.

Journal of immunology (Baltimore, Md. : 1950)

Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C

Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection.

Journal of immunology (Baltimore, Md. : 1950)

Kamen LA, Schlessinger J, Lowell CA

Interferon-γ production by neutrophils during bacterial pneumonia in mice.

American journal of respiratory and critical care medicine

Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM

Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia.

Blood

Cihangir Duy, Daniel Nowak, Lars Klemm, Rahul Nahar, Carina Ng, Emily Elliott, Wolf-Karsten Hofmann, Nora Heisterkamp, Clifford A. Lowell, Phillip Koeffler, Markus Muschen

SYK Is a Tumor Suppressor In Pre-B Cell Acute Lymphoblastic Leukemia and Not a Therapeutic Target.

Blood

Carina Ng, Rahul Nahar, Emily Elliott, Clifford A. Lowell, Markus Muschen

The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

Immunity

Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

The Journal of experimental medicine

Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA

Abstract 2728: Multivariate analysis of cerebrospinal fluid protein biomarkers in central nervous system lymphoma patients and controls.

Clinical Research

Valerie S. Wong, Lingjing Chen, Cigall Kadoch, Anly Tsang, Lisa Siu, Clifford Lowell, James L. Rubenstein

Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma.

Clinical Research

Cigall Kadoch, Valerie S. Wong, Tara C. Rambaldo, William C. Hyun, Hua Xin Gao, Clifford A. Lowell, James L. Rubenstein

An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.

The Journal of biological chemistry

Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X

Management practices and phytoremediation by native grasses.

International journal of phytoremediation

Nedunuri KV, Lowell C, Meade W, Vonderheide AP, Shann JR

c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.

FEBS letters

Baruzzi A, Iacobucci I, Soverini S, Lowell CA, Martinelli G, Berton G

Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma.

Blood

Cigall Kadoch, Valerie D. Wong, Tara Rambaldo, William Hyun, Clifford Lowell, James Rubenstein

Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.

Blood

Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mège JL, Tabouret G, Lowell CA, Laviolette-Malirat N, Maridonneau-Parini I

The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.

Immunological reviews

Hamerman JA, Ni M, Killebrew JR, Chu CL, Lowell CA

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA

Microarray kit analysis of cytokines in blood product units and segments.

Transfusion

Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P

Leukocyte adhesion deficiency syndrome: a controversy solved.

Immunology and cell biology

Abram CL, Lowell CA

CalDAG-GEF-I is required for E-selectin-dependent slow leukocyte rolling (94.2).

The Journal of Immunology

Alexander Zarbock, Helena Mueller, Wolfgang Bergmeier, Clifford A. Lowell, Hugo Van Aken, Denisa D. Wagner, Klaus Ley

Receptor-independent, lipid dependent mechanism of Syk kinase activation in dendritic cells (134.71).

The Journal of Immunology

Gilbert Ng, Karan Sharma, Sandra M Ward, Melanie D Desrosiers, Leslie A Stephens, Michael Schoel, Tonglei Li, Clifford A Lowell, Chang-Chun Ling, Matthias W Amrein, Yan Shi

Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL

Multiple roles of Lyn kinase in myeloid cell signaling and function.

Immunological reviews

Scapini P, Pereira S, Zhang H, Lowell CA

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.

Journal of Experimental Medicine

Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman

Erratum: Corrigendum: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

Nature immunology

Jessica A Hamerman, Nadia K Tchao, Clifford A Lowell, Lewis L Lanier

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.

The Journal of cell biology

N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE

Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells.

Journal of immunology (Baltimore, Md. : 1950)

Miller AL, Zhang C, Shokat KM, Lowell CA

The ins and outs of leukocyte integrin signaling.

Annual review of immunology

Abram CL, Lowell CA

Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.

Journal of immunology (Baltimore, Md. : 1950)

Sarantos MR, Zhang H, Schaff UY, Dixit N, Hayenga HN, Lowell CA, Simon SI

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.

Immunity

Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, Shi Y

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.

The Journal of experimental medicine

Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K

Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.

Journal of thrombosis and haemostasis : JTH

Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.

Journal of leukocyte biology

Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U

The diverse functions of Src family kinases in macrophages.

Frontiers in bioscience : a journal and virtual library

Abram CL, Lowell CA

Increased TLR Responses in Dendritic Cells Lacking the Itam-Containing Adapters Dap12 and FcR?.

The FASEB Journal

Jessica A Hamerman, Yen-Ling Yu, Kuan-Yin Shen, Clifford A Lowell, Lewis L Lanier, Ching-Liang Chu

Regulation of myeloproliferation and M2 macrophage programming by Lyn/Hck, SHIP and Stat5.

The FASEB Journal

Wenbin Xiao, Hong Hong, Yuko Kawakami, Clifford A. Lowell, Toshiaki Kawakami

Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.

The Journal of clinical investigation

Xiao W, Hong H, Kawakami Y, Lowell CA, Kawakami T

Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.

European journal of immunology

Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA

Immunoreceptor-like signaling by beta 2 and beta 3 integrins.

Trends in cell biology

Jakus Z, Fodor S, Abram CL, Lowell CA, Mócsai A

Convergence of immunoreceptor and integrin signaling.

Immunological reviews

Abram CL, Lowell CA

TRALI--definition, mechanisms, incidence and clinical relevance.

Best practice & research. Clinical anaesthesiology

Toy P, Lowell C

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.

Blood

Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T

Inhibition of Toll-like receptor and Fc receptor responses in macrophages by TREM-2 and DAP12 (44.7).

The Journal of Immunology

Jessica A Hamerman, Jessica R Jarjoura, Nadia K Tchao, Mary Beth Humphrey, Mary C Nakamura, Clifford A Lowell, William E Seaman, Lewis L Lanier

The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine.

Journal of immunology (Baltimore, Md. : 1950)

Fumagalli L, Zhang H, Baruzzi A, Lowell CA, Berton G

The expanding role for ITAM-based signaling pathways in immune cells.

Science's STKE : signal transduction knowledge environment

Abram CL, Lowell CA

Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines.

The FASEB Journal

Mark R Looney, Rebecca Barbeau, Andrea Barczak, Yuanyuan Xiao, Clifford A Lowell, David J Erle, Michael A Matthay

Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.

The Journal of experimental medicine

Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH

Src family kinases mediate neutrophil adhesion to adherent platelets.

Blood

Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, Smyth SS

Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.

Immunity

Zhang H, Schaff UY, Green CE, Chen H, Sarantos MR, Hu Y, Wara D, Simon SI, Lowell CA

Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.

Immunity

Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.

Blood

Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC

Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.

The Journal of clinical investigation

Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA

Lyn kinase promotes erythroblast expansion and late-stage development.

Blood

Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM

Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.

The Biochemical journal

Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V

A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.

Journal of thrombosis and haemostasis : JTH

Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ

Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.

Journal of immunology (Baltimore, Md. : 1950)

Yu M, Lowell CA, Neel BG, Gu H

Beautiful blistering.

Blood

Clifford A. Lowell

Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.

Blood

Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R

Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Hernandez-Hansen V, Bard JD, Tarleton CA, Wilder JA, Lowell CA, Wilson BS, Oliver JM

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.

Journal of immunology (Baltimore, Md. : 1950)

Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T

Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes.

Pflugers Archiv : European journal of physiology

De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G

The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.

Journal of immunology (Baltimore, Md. : 1950)

Chu CL, Lowell CA

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

Nature immunology

Hamerman JA, Tchao NK, Lowell CA, Lanier LL

Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.

Journal of immunology (Baltimore, Md. : 1950)

Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, Kawakami T

Src and Syk kinases: key regulators of phagocytic cell activation.

Trends in immunology

Berton G, Mócsai A, Lowell CA

The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.

Experimental cell research

Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell CA, Berton G

IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.

Blood

Kitaura J, Kinoshita T, Matsumoto M, Chung S, Kawakami Y, Leitges M, Wu D, Lowell CA, Kawakami T

Lyn Kinase Supports Primary Erythroid Progenitor Cell Development.

Blood

Vinit Karur, Bethany Vincent, Clifford Lowell, Don M. Wojchowski

The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.

Journal of immunology (Baltimore, Md. : 1950)

Pereira S, Zhang H, Takai T, Lowell CA

Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.

Nature immunology

Tassiulas I, Hu X, Ho H, Kashyap Y, Paik P, Hu Y, Lowell CA, Ivashkiv LB

Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival.

Journal of immunology (Baltimore, Md. : 1950)

Kitaura J, Xiao W, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Kawakami T

Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

Journal of immunology (Baltimore, Md. : 1950)

Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM

Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.

The Journal of clinical investigation

Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO

CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A.

Journal of immunology (Baltimore, Md. : 1950)

Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, Albini A, Lowell C, Berton G, Noonan DM, Cassatella MA

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.

Proceedings of the National Academy of Sciences of the United States of America

Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC

SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils.

Immunity

Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

Proceedings of the National Academy of Sciences of the United States of America

Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, Galli SJ, Kawakami T

The Src kinase Lyn is a negative regulator of mast cell proliferation.

Journal of leukocyte biology

Hernandez-Hansen V, Mackay GA, Lowell CA, Wilson BS, Oliver JM

Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice.

Journal of immunology (Baltimore, Md. : 1950)

Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB

The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.

Journal of immunology (Baltimore, Md. : 1950)

Pereira S, Lowell C

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading.

Immunity

Chen H, Mocsai A, Zhang H, Ding RX, Morisaki JH, White M, Rothfork JM, Heiser P, Colucci-Guyon E, Lowell CA, Gresham HD, Allen PM, Brown EJ

Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.

Journal of cellular physiology

Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DD, Lowell CA, Berton G

Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.

Nature immunology

Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.

Blood

Mócsai A, Zhang H, Jakus Z, Kitaura J, Kawakami T, Lowell CA

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

Science (New York, N.Y.)

Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML

Tumor necrosis factor-alpha-induced leukocyte adhesion and microvessel permeability.

American journal of physiology. Heart and circulatory physiology

Zeng M, Zhang H, Lowell C, He P

Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Vicentini L, Mazzi P, Caveggion E, Continolo S, Fumagalli L, Lapinet-Vera JA, Lowell CA, Berton G

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

The Journal of cell biology

Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ

Syk is required for integrin signaling in neutrophils.

Immunity

Mócsai A, Zhou M, Meng F, Tybulewicz VL, Lowell CA

Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Stafford S, Lowell C, Sur S, Alam R

Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor.

Molecular therapy : the journal of the American Society of Gene Therapy

Dan Q, Sanchez R, Delgado C, Wepsic HT, Morgan K, Chen Y, Jeffes EW, Lowell CA, Morgan TR, Jadus MR

Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.

Journal of leukocyte biology

Majeed M, Caveggion E, Lowell CA, Berton G

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.

Immunity

Vines CM, Potter JW, Xu Y, Geahlen RL, Costello PS, Tybulewicz VL, Lowell CA, Chang PW, Gresham HD, Willman CL

A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.

Journal of immunology (Baltimore, Md. : 1950)

Hasegawa M, Fujimoto M, Poe JC, Steeber DA, Lowell CA, Tedder TF

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.

Blood

O'Laughlin-Bunner B, Radosevic N, Taylor ML, DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D

Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.

Journal of immunology (Baltimore, Md. : 1950)

Pereira S, Zhou M, Mócsai A, Lowell C

Fyn and Lyn phosphorylate the Fc receptor ? chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

Blood

Lynn S. Quek, Jean-Max Pasquet, Ingeborg Hers, Richard Cornall, Graham Knight, Michael Barnes, Margaret L. Hibbs, Ashley R. Dunn, Clifford A. Lowell, Steve P. Watson

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

Blood

Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP

Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI.

The Journal of biological chemistry

Pasquet JM, Quek L, Pasquet S, Poole A, Matthews JR, Lowell C, Watson SP

Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.

Immunity

Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF

Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.

Proceedings of the National Academy of Sciences of the United States of America

Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP, Kawakami T

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.

Proceedings of the National Academy of Sciences of the United States of America

Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON

Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases.

Journal of immunology (Baltimore, Md. : 1950)

Mócsai A, Jakus Z, Vántus T, Berton G, Lowell CA, Ligeti E

Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta.

Journal of leukocyte biology

Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL

Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.

The Journal of experimental medicine

Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA

Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr.

The Journal of experimental medicine

Gresham HD, Dale BM, Potter JW, Chang PW, Vines CM, Lowell CA, Lagenaur CF, Willman CL

Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates.

British journal of haematology

Brady KA, Atwater SK, Lowell CA

Integrin signalling in neutrophils and macrophages.

Cellular signalling

Berton G, Lowell CA

Integrin signal transduction in myeloid leukocytes.

Journal of leukocyte biology

Lowell CA, Berton G

Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.

Journal of immunology (Baltimore, Md. : 1950)

Mócsai A, Ligeti E, Lowell CA, Berton G

Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.

The Journal of experimental medicine

Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON

Positive and negative roles of the tyrosine kinase Lyn in B cell function.

Seminars in immunology

DeFranco AL, Chan VW, Lowell CA

The molecular mechanism of B cell activation by toll-like receptor protein RP-105.

The Journal of experimental medicine

Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A

Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.

Proceedings of the National Academy of Sciences of the United States of America

Lowell CA, Berton G

Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Jadus MR, Williams CC, Avina MD, Ly M, Kim S, Liu Y, Narasaki R, Lowell CA, Wepsic HT

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

Genes & development

Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.

The Journal of experimental medicine

Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL

Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.

The Journal of clinical investigation

De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G

Neutrophil activation by adhesion: mechanisms and pathophysiological implications.

International journal of clinical & laboratory research

Berton G, Yan SR, Fumagalli L, Lowell CA

Cancer genes and hematopoiesis.

Blood

Varmus HE, Lowell CA

Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.

The Journal of experimental medicine

Lowell CA, Klickstein LB, Carter RH, Mitchell JA, Fearon DT, Ahearn JM

Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing.

American journal of clinical pathology

Shirey RS, Morton SJ, Lawton KB, Lowell C, Kickler TS, Ness PM

Structure of the murine serum amyloid A gene family. Gene conversion.

The Journal of biological chemistry

Lowell CA, Potter DA, Stearman RS, Morrow JF

Transcriptional regulation of serum amyloid A gene expression.

The Journal of biological chemistry

Lowell CA, Stearman RS, Morrow JF

The sequence and structure of a new serum amyloid A gene.

Nucleic acids research

Stearman RS, Lowell CA, Peltzman CG, Morrow JF

Regulation of synthesis of amyloid A-related protein.

Annals of the New York Academy of Sciences

Stearman RS, Lowell CA, Pearson WR, Morrow JF

S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops.

Analytical biochemistry

Lowell C, Bogenhagen D, Clayton DA

Topical anesthetic effectiveness. An old and new product evaluated.

The New York journal of dentistry

Howitt JW, Lowell C

Topical anesthetic effectiveness. An old and new product evaluated.

The New York state dental journal

Howitt JW, Lowell C