Professor
          Laboratory Medicine
          +1 415 476-2963
      Clifford Lowell, MD, PhD studies the role of Src family kinases and the Syk tyrosine kinase in signal transduction pathways within hematopoietic cells.
Publications
THE TOLL-LIKE RECEPTOR 7/8 PATHWAY HAS PROGNOSTIC SIGNIFICANCE AND IS A THERAPEUTIC TARGET IN CNS LYMPHOMAS.
Hematological oncology
      
            
      
      THERAPY-DRIVEN EVOLUTION AND INTRATUMORAL GENETIC HETEROGENEITY IN CNS LYMPHOMAS.
Hematological oncology
      
            
      
      INTEGRIN FUNCTION IN LEUKOCYTE-MEDIATED INFLAMMATION-ACTINOPATHIES IN IMMUNE DISEASES.
Transactions of the American Clinical and Climatological Association
      
            
      
      Leukocyte Integrins: Regulation of Immune Cell Trafficking and Activation.
Reference Module in Life Sciences
      
            
      
      Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury.
The Journal of clinical investigation
      
            
      
      TLR Engagement Induces an Alternate Pathway for BCR Signaling that Results in PKCδ Phosphorylation.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury.
bioRxiv : the preprint server for biology
      
            
      
      Expression of Concern: Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Transcriptomic Analyses of B Cells Infected In Vitro with Transmitted/Founder HIV-1 of R5 Phenotype (HIV-R5) Reveal Downregulation of IGLL1 Gene in Persistent Infection.
The Journal of Immunology
      
            
      
      Validation of a murine proteome-wide phage display library for identification of autoantibody specificities.
JCI insight
      
            
      
      Thrombopoietin levels in sepsis and septic shock - a systematic review and meta-analysis.
Clinical chemistry and laboratory medicine
      
            
      
      Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models.
The Journal of experimental medicine
      
            
      
      Validation of a murine proteome-wide phage display library for the identification of autoantibody specificities.
bioRxiv : the preprint server for biology
      
            
      
      NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases.
The American journal of pathology
      
            
      
      Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis.
Frontiers in immunology
      
            
      
      Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
      
            
      
      Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection.
The Journal of Immunology
      
            
      
      Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells.
The Journal of Immunology
      
            
      
      A dominant function of LynB kinase in preventing autoimmunity.
Science advances
      
            
      
      Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury.
Journal of neuroinflammation
      
            
      
      Signal Integration by Translocation and Phosphorylation of PKCδ in the B Cell Alternate Pathway.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels.
Journal of virology
      
            
      
      Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation.
Diabetes care
      
            
      
      Neutrophil-specific deletion of Syk results in recruitment-independent stabilization of the barrier and a long-term improvement in cognitive function after traumatic injury to the developing brain.
Neurobiology of disease
      
            
      
      Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling.
Cell reports
      
            
      
      A CD22-Shp1 phosphatase axis controls integrin ß 7 display and B cell function in mucosal immunity.
The FASEB Journal
      
            
      
      Activation of Lyn kinase and translocation of its PKCd target regulate phosphorylation in the IL-4-induced alternate pathway for BCR signaling.
The Journal of Immunology
      
            
      
      Correlation of autoantigen-specific Treg frequency with development of spontaneous organ-specific autoimmunity in a mouse model of uveitis.
The Journal of Immunology
      
            
      
      T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement.
The Journal of Immunology
      
            
      
      A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity.
Nature immunology
      
            
      
      A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
American journal of physiology. Lung cellular and molecular physiology
      
            
      
      Complement activation on endothelium initiates antibody-mediated acute lung injury.
The Journal of clinical investigation
      
            
      
      Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
      
            
      
      ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.
Infection and immunity
      
            
      
      Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.
Cancer immunology research
      
            
      
      Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.
The Journal of clinical investigation
      
            
      
      Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration.
Haematologica
      
            
      
      CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.
Science signaling
      
            
      
      Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.
Blood advances
      
            
      
      PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.
British journal of pharmacology
      
            
      
      Neutrophils: Their Role in Innate and Adaptive Immunity 2017.
Journal of immunology research
      
            
      
      B cell autoimmunity at the extremes.
Nature immunology
      
            
      
      Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice.
American journal of respiratory cell and molecular biology
      
            
      
      Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.
Journal of leukocyte biology
      
            
      
      Shp1 function in myeloid cells.
Journal of leukocyte biology
      
            
      
      Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
Transfusion
      
            
      
      Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Cancer cell
      
            
      
      Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.
The Journal of experimental medicine
      
            
      
      Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting.
Bio-protocol
      
            
      
      LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
The Journal of clinical investigation
      
            
      
      Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.
PLoS pathogens
      
            
      
      Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.
American journal of respiratory cell and molecular biology
      
            
      
      Triggering of organ-specific autoimmunity through synergy of defects in key tolerance checkpoints.
The Journal of Immunology
      
            
      
      FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.
PLoS pathogens
      
            
      
      Neutrophils in animal models of autoimmune disease.
Seminars in immunology
      
            
      
      Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Nature
      
            
      
      Abstract PR11: Targeted engagement of B cell autoimmunity checkpoints to overcome drug resistance in pediatric Ph-like ALL.
Targeted Therapeutics and Resistance
      
            
      
      Neutrophils: Their Role in Innate and Adaptive Immunity.
Journal of immunology research
      
            
      
      Integrins: Regulation of Adhesion and Downstream Signaling.
Encyclopedia of Immunobiology
      
            
      
      Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice.
Shock (Augusta, Ga.)
      
            
      
      Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia.
Molecular and cellular biology
      
            
      
      The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Intracellular signalling during neutrophil recruitment.
Cardiovascular research
      
            
      
      Regulation of neutrophil cytokine production during inflammation (INC6P.319).
The Journal of Immunology
      
            
      
      A2.21 The role of HCK, FGR and LYN in in vivo inflammation in mice.
Annals of the Rheumatic Diseases
      
            
      
      Store-operated calcium signaling in neutrophils.
Journal of leukocyte biology
      
            
      
      Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
Transfusion
      
            
      
      Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia.
Blood
      
            
      
      The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
The Journal of experimental medicine
      
            
      
      Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.
Critical care medicine
      
            
      
      Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering.
Developmental cell
      
            
      
      Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice.
Journal of immunological methods
      
            
      
      ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.
Cell metabolism
      
            
      
      Molecular editing of cellular responses by the high-affinity receptor for IgE.
Science (New York, N.Y.)
      
            
      
      Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      B cell-specific loss of Lyn kinase leads to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
      
            
      
      The multifaceted functions of neutrophils.
Annual review of pathology
      
            
      
      Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
      
            
      
      The roles of tumor associated macrophages and interferon gamma in immune surveillance in CNS lymphoma (P2211).
The Journal of Immunology
      
            
      
      Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
Developmental cell
      
            
      
      Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.
Journal of cell science
      
            
      
      Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.
The Journal of biological chemistry
      
            
      
      Distinct and overlapping functional roles of Src family kinases in mouse platelets.
Journal of thrombosis and haemostasis : JTH
      
            
      
      Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
The Journal of experimental medicine
      
            
      
      Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.
Anesthesia and analgesia
      
            
      
      Establishment of a Novel System for Studying the Syk Function in B Cells.
Chembiomolecular Science
      
            
      
      Overview: studying integrins in vivo.
Methods in molecular biology (Clifton, N.J.)
      
            
      
      B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa.
Journal of leukocyte biology
      
            
      
      Deletion of Syk in neutrophils prevents immune complex arthritis.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Differential transformation capacity of Src family kinases during the initiation of prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      BCAP negatively regulates TLR signaling in macrophages (116.13).
The Journal of Immunology
      
            
      
      Neutrophils give us a shock.
The Journal of clinical investigation
      
            
      
      Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.
Cold Spring Harbor perspectives in biology
      
            
      
      IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Interferon-γ production by neutrophils during bacterial pneumonia in mice.
American journal of respiratory and critical care medicine
      
            
      
      SYK Is a Tumor Suppressor In Pre-B Cell Acute Lymphoblastic Leukemia and Not a Therapeutic Target.
Blood
      
            
      
      Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
The Journal of experimental medicine
      
            
      
      Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy.
Journal of Clinical Oncology
      
            
      
      Abstract 2728: Multivariate analysis of cerebrospinal fluid protein biomarkers in central nervous system lymphoma patients and controls.
Clinical Research
      
            
      
      Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma.
Clinical Research
      
            
      
      An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.
The Journal of biological chemistry
      
            
      
      Management practices and phytoremediation by native grasses.
International journal of phytoremediation
      
            
      
      The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.
Immunological reviews
      
            
      
      Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
The Journal of clinical investigation
      
            
      
      Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
Blood
      
            
      
      Leukocyte adhesion deficiency syndrome: a controversy solved.
Immunology and cell biology
      
            
      
      CalDAG-GEF-I is required for E-selectin-dependent slow leukocyte rolling (94.2).
The Journal of Immunology
      
            
      
      Receptor-independent, lipid dependent mechanism of Syk kinase activation in dendritic cells (134.71).
The Journal of Immunology
      
            
      
      Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research
      
            
      
      The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.
Infection and immunity
      
            
      
      Multiple roles of Lyn kinase in myeloid cell signaling and function.
Immunological reviews
      
            
      
      TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.
Journal of Experimental Medicine
      
            
      
      Erratum: Corrigendum: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.
Nature immunology
      
            
      
      TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.
The Journal of cell biology
      
            
      
      Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      The ins and outs of leukocyte integrin signaling.
Annual review of immunology
      
            
      
      Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.
The Journal of experimental medicine
      
            
      
      Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.
Journal of thrombosis and haemostasis : JTH
      
            
      
      Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
Journal of leukocyte biology
      
            
      
      The diverse functions of Src family kinases in macrophages.
Frontiers in bioscience : a journal and virtual library
      
            
      
      Immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcR? required for E-selectin mediated slow rolling.
The FASEB Journal
      
            
      
      Increased TLR Responses in Dendritic Cells Lacking the Itam-Containing Adapters Dap12 and FcR?.
The FASEB Journal
      
            
      
      Regulation of myeloproliferation and M2 macrophage programming by Lyn/Hck, SHIP and Stat5.
The FASEB Journal
      
            
      
      Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.
The Journal of clinical investigation
      
            
      
      Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.
European journal of immunology
      
            
      
      Immunoreceptor-like signaling by beta 2 and beta 3 integrins.
Trends in cell biology
      
            
      
      Convergence of immunoreceptor and integrin signaling.
Immunological reviews
      
            
      
      TRALI--definition, mechanisms, incidence and clinical relevance.
Best practice & research. Clinical anaesthesiology
      
            
      
      Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      B Cell Receptor Crosstalk: The IL-4-induced Alternate Pathway for BCR Signaling Operates in Parallel with the Classical Pathway, Is Sensitive to Rottlerin, and Depends on Lyn (86.14).
The Journal of Immunology
      
            
      
      Inhibition of Toll-like receptor and Fc receptor responses in macrophages by TREM-2 and DAP12 (44.7).
The Journal of Immunology
      
            
      
      The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      The expanding role for ITAM-based signaling pathways in immune cells.
Science's STKE : signal transduction knowledge environment
      
            
      
      Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines.
The FASEB Journal
      
            
      
      Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
The Journal of experimental medicine
      
            
      
      Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.
Nature immunology
      
            
      
      The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained a
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
The Journal of clinical investigation
      
            
      
      Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.
The Biochemical journal
      
            
      
      A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.
Journal of thrombosis and haemostasis : JTH
      
            
      
      Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Beautiful blistering.
Blood
      
            
      
      Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes.
Pflugers Archiv : European journal of physiology
      
            
      
      The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.
Biochemical pharmacology
      
            
      
      The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Src and Syk kinases: key regulators of phagocytic cell activation.
Trends in immunology
      
            
      
      The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
Experimental cell research
      
            
      
      The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.
Nature immunology
      
            
      
      Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.
The Journal of clinical investigation
      
            
      
      Src-family kinases: rheostats of immune cell signaling.
Molecular immunology
      
            
      
      CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      The Src kinase Lyn is a negative regulator of mast cell proliferation.
Journal of leukocyte biology
      
            
      
      Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading.
Immunity
      
            
      
      Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
Journal of cellular physiology
      
            
      
      Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.
Nature immunology
      
            
      
      Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
Science (New York, N.Y.)
      
            
      
      Tumor necrosis factor-alpha-induced leukocyte adhesion and microvessel permeability.
American journal of physiology. Heart and circulatory physiology
      
            
      
      Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
The Journal of cell biology
      
            
      
      Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor.
Molecular therapy : the journal of the American Society of Gene Therapy
      
            
      
      Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.
Journal of leukocyte biology
      
            
      
      A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.
Current biology : CB
      
            
      
      Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI.
The Journal of biological chemistry
      
            
      
      Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta.
Journal of leukocyte biology
      
            
      
      Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.
The Journal of experimental medicine
      
            
      
      Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr.
The Journal of experimental medicine
      
            
      
      Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates.
British journal of haematology
      
            
      
      Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.
Journal of cell science
      
            
      
      Integrin signalling in neutrophils and macrophages.
Cellular signalling
      
            
      
      Integrin signal transduction in myeloid leukocytes.
Journal of leukocyte biology
      
            
      
      Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
The Journal of experimental medicine
      
            
      
      A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.
The EMBO journal
      
            
      
      Positive and negative roles of the tyrosine kinase Lyn in B cell function.
Seminars in immunology
      
            
      
      The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
The Journal of experimental medicine
      
            
      
      Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
Current biology : CB
      
            
      
      Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.
Genes & development
      
            
      
      A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.
The Journal of experimental medicine
      
            
      
      Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn.
The Journal of experimental medicine
      
            
      
      Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.
The Journal of clinical investigation
      
            
      
      Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.
Genes & development
      
            
      
      Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.
The Journal of cell biology
      
            
      
      Neutrophil activation by adhesion: mechanisms and pathophysiological implications.
International journal of clinical & laboratory research
      
            
      
      Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
Genes & development
      
            
      
      Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.
The Journal of experimental medicine
      
            
      
      Sucrose-metabolizing enzymes in transport tissues and adjacent sink structures in developing citrus fruit.
Plant physiology
      
            
      
      Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing.
American journal of clinical pathology
      
            
      
      Structure of the murine serum amyloid A gene family. Gene conversion.
The Journal of biological chemistry
      
            
      
      Transcriptional regulation of serum amyloid A gene expression.
The Journal of biological chemistry
      
            
      
      The sequence and structure of a new serum amyloid A gene.
Nucleic acids research
      
            
      
      Regulation of synthesis of amyloid A-related protein.
Annals of the New York Academy of Sciences
      
            
      
      Mechanism of mitochondrial DNA replication in mouse L-cells. Replication of unicircular dimer molecules.
Journal of molecular biology
      
            
      
      S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops.
Analytical biochemistry
      
            
      
      Topical anesthetic effectiveness. An old and new product evaluated.
The New York journal of dentistry
      
            
      
      Topical anesthetic effectiveness. An old and new product evaluated.
The New York state dental journal