
Associate Professor
Neurological Surgery
+1 415 476-6786
Bjoern Schwer, MD, PhD is investigating molecular processes that affect genomic stability in developing and mature neural lineage cells, and the role of these processes in development, aging and cancers of the brain.
Publications
Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration.
bioRxiv : the preprint server for biology
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression.
Scientific reports
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression.
bioRxiv : the preprint server for biology
MDB-09. IMPACT OF PRDM6 ON CHROMATIN ACCESSIBILITY, GENE EXPRESSION, AND MEDULLOBLASTOMA FORMATION.
Neuro-oncology
Type I interferon responsive microglia shape cortical development and behavior.
bioRxiv : the preprint server for biology
MODL-32. IMPACT OF PRDM6 ON CHROMATIN ACCESSIBILITY, GENE EXPRESSION, AND MEDULLOBLASTOMA FORMATION.
Neuro-oncology
Relationships between genome-wide R-loop distribution and classes of recurrent DNA breaks in neural stem/progenitor cells.
Scientific reports
Editorial: Genomic Instability and Neurodegeneration.
Frontiers in aging neuroscience
Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice.
Neuro-oncology
BIOL-11. THE ROLE OF ABERRANT EXPRESSION OF PRDM6 IN THE DEVELOPING CEREBELLUM AND IN GROUP 4 MEDULLOBLASTOMA.
Neuro-oncology
TMOD-28. NEW APPROACHES FOR ELUCIDATING MEDULLOBLASTOMA DEVELOPMENT VIA HINDBRAIN BLASTOCYST COMPLEMENTATION.
Neuro-oncology
Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay.
Proceedings of the National Academy of Sciences of the United States of America
Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America
Editorial: DNA damage & immunity.
Mechanisms of ageing and development
Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer.
Genome Editing in Neurosciences
Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America
IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.
Proceedings of the National Academy of Sciences of the United States of America
Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.
PLoS genetics
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
Proceedings of the National Academy of Sciences of the United States of America
Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.
Proceedings of the National Academy of Sciences of the United States of America
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).
Proceedings of the National Academy of Sciences of the United States of America
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks.
Advances in immunology
SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism.
Cold Spring Harbor symposia on quantitative biology
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Molecular cell
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.
Nature immunology
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Cell metabolism
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.
Proceedings of the National Academy of Sciences of the United States of America
Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.
Biochemical Society Transactions
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.
Proceedings of the National Academy of Sciences of the United States of America
Conserved metabolic regulatory functions of sirtuins.
Cell metabolism
SIRT6 in DNA repair, metabolism and ageing.
Journal of internal medicine
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.
The Journal of biological chemistry
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.
Proceedings of the National Academy of Sciences of the United States of America
The Class III Protein Deacetylases.
Histone Deacetylases
Preparation of enzymatically active recombinant class III protein deacetylases.
Methods (San Diego, Calif.)
Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif.
Journal of virology
Release and intercellular transfer of cell surface CD81 via microparticles.
Journal of immunology (Baltimore, Md. : 1950)
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.
The Journal of cell biology
A new twist on RNA helicases: DExH/D box proteins as RNPases.
Nature structural biology
RNA helicase dynamics in pre-mRNA splicing.
The EMBO journal
Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicing.
Nucleic acids research
Trans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons.
RNA (New York, N.Y.)
Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme.
Nucleic acids research
Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicing.
The EMBO journal
Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A.
Nucleic acids research
Functional and physical interaction between the yeast splicing factors Slu7 and Prp18.
Nucleic acids research
Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site.
RNA (New York, N.Y.)
Conditional inactivation of mRNA capping enzyme affects yeast pre-mRNA splicing in vivo.
RNA (New York, N.Y.)
SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing.
The EMBO journal