
Professor
Pediatrics
+1 415 734-2708
Benoit Bruneau, PhD is the Director of the Gladstone Institute of Cardiovascular Disease. He studies the transcriptional and epigenetic regulation of cardiogenesis.
Publications
Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis.
Journal of the American Heart Association
Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor.
bioRxiv : the preprint server for biology
4D light sheet imaging, computational reconstruction, and cell tracking in mouse embryos.
STAR protocols
Heart tube morphogenesis is regulated by segment-specific gene regulatory networks controlled by MEF2C.
bioRxiv : the preprint server for biology
TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids.
Development (Cambridge, England)
A TBX5-dependent compartment boundary patterns the cardiac interventricular septum.
bioRxiv : the preprint server for biology
CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development.
Biology open
CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development.
bioRxiv : the preprint server for biology
TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids.
bioRxiv : the preprint server for biology
Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project.
Molecular cell
A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors.
Development (Cambridge, England)
Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma.
Nature communications
Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis.
Bioinformatics advances
Targeting transcription in heart failure via CDK7/12/13 inhibition.
Nature communications
Modeling congenital heart disease: lessons from mice, hPSC-based models, and organoids.
Genes & development
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids.
Cell stem cell
Dissecting CTCF site function in a tense HoxD locus.
Genes & development
Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency.
Circulation research
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease.
Developmental cell
WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.
Nature genetics
Molecular basis of CTCF binding polarity in genome folding.
Nature communications
The developing heart: from The Wizard of Oz to congenital heart disease.
Development (Cambridge, England)
Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
Nature immunology
Author Correction: Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation.
Genome biology
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
The Journal of clinical investigation
Cardiac natriuretic peptides.
Nature reviews. Cardiology
Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation.
Genome biology
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
Nature immunology
Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs.
Development (Cambridge, England)
Chromatin and epigenetics in development: a Special Issue.
Development (Cambridge, England)
Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.
Nature ecology & evolution
Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis.
Development (Cambridge, England)
Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development.
Nature communications
A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse.
Biology open
Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites.
Development (Cambridge, England)
Single-Cell Resolution of Temporal Gene Expression during Heart Development.
Developmental cell
ATP-dependent chromatin remodeling during mammalian development.
Development (Cambridge, England)
Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.
Bone reports
KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.
Development (Cambridge, England)
Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor.
Molecular biology and evolution
Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms.
Cell stem cell
Brg1 modulates enhancer activation in mesoderm lineage commitment.
Development (Cambridge, England)
Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.
BMC evolutionary biology
Investigating the transcriptional control of cardiovascular development.
Circulation research
Looking inwards: opening a window onto human development.
Development (Cambridge, England)
Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature.
Development (Cambridge, England)
HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.
Genes & development
Function-based identification of mammalian enhancers using site-specific integration.
Nature methods
Congenital heart disease: entering a new era of human genetics.
Circulation research
Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.
Molecular cell
An interview with Benoit Bruneau.
Development (Cambridge, England)
Chromatin modulators as facilitating factors in cellular reprogramming.
Current opinion in genetics & development
ETS factors regulate Vegf-dependent arterial specification.
Developmental cell
Stem cells and regeneration: a special issue.
Development (Cambridge, England)
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.
Genome biology
Signaling and transcriptional networks in heart development and regeneration.
Cold Spring Harbor perspectives in biology
Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6.
Development (Cambridge, England)
Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.
Development (Cambridge, England)
Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage.
Cell
Iroquois homeodomain transcription factors in heart development and function.
Circulation research
Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
Nature genetics
Epigenetics and cardiovascular development.
Annual review of physiology
Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.
Proceedings of the National Academy of Sciences of the United States of America
Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis.
Canadian journal of physiology and pharmacology
Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.
Development (Cambridge, England)
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
The Journal of cell biology
A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.
Development (Cambridge, England)
Chromatin remodelling complex dosage modulates transcription factor function in heart development.
Nature communications
CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors.
The Journal of biological chemistry
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.
Proceedings of the National Academy of Sciences of the United States of America
Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart.
Human molecular genetics
Chromatin remodeling in heart development.
Current opinion in genetics & development
Epigenetic regulation of the cardiovascular system: introduction to a review series.
Circulation research
Lessons for cardiac regeneration and repair through development.
Trends in molecular medicine
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.
Human molecular genetics
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.
The Journal of biological chemistry
Alternative induced pluripotent stem cell characterization criteria for in vitro applications.
Cell stem cell
Influence of cysteamine on in vitro maturation, in vitro and in vivo fertilization of equine oocytes.
Reproduction in domestic animals = Zuchthygiene
miR-126 regulates angiogenic signaling and vascular integrity.
Developmental cell
Tbx5-dependent pathway regulating diastolic function in congenital heart disease.
Proceedings of the National Academy of Sciences of the United States of America
4D cardiac MRI in the mouse.
NMR in biomedicine
The heart's Da Vinci code: a Renaissance at Keystone.
Development (Cambridge, England)
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.
Proceedings of the National Academy of Sciences of the United States of America
Irxl1, a divergent Iroquois homeobox family transcription factor gene.
Gene expression patterns : GEP
Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Developmental biology
Chromatin modification and remodeling in heart development.
TheScientificWorldJournal
[Irx5: a transcription factor that regulates the cardiac repolarization gradient].
Medecine sciences : M/S
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Nature genetics
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.
Development (Cambridge, England)
The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.
Developmental biology
Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.
Molecular and cellular biology
Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome.
American journal of physiology. Heart and circulatory physiology
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.
Development (Cambridge, England)
Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes.
The Journal of biological chemistry
The functional landscape of mouse gene expression.
Journal of biology
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
Nature
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
The EMBO journal
The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Development (Cambridge, England)
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.
Development (Cambridge, England)
TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed.
Current opinion in cardiology
The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.
Molecular and cellular biology
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.
Developmental biology
Tbx5 is required for forelimb bud formation and continued outgrowth.
Development (Cambridge, England)
Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.
Development (Cambridge, England)
Transcriptional regulation of vertebrate cardiac morphogenesis.
Circulation research
Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
Molecular and cellular biology
Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.
Developmental biology
Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.
Developmental biology
Characterization of natriuretic peptide production by adult heart atria.
The American journal of physiology
Regulation of chamber-specific gene expression in the developing heart by Irx4.
Science (New York, N.Y.)
BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria.
The American journal of physiology
Tissue-specific regulation of renal and cardiac atrial natriuretic factor gene expression in deoxycorticosterone acetate-salt rats.
Hypertension (Dallas, Tex. : 1979)
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.
Nature genetics
Evidence for load-dependent and load-independent determinants of cardiac natriuretic peptide production.
Circulation
Mechanical and neuroendocrine regulation of the endocrine heart.
Cardiovascular research
Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats.
American journal of hypertension
Atrial natriuretic factor significantly contributes to the mineralocorticoid escape phenomenon. Evidence for a guanylate cyclase-mediated pathway.
The Journal of clinical investigation