
Professor
Neurology
Arnold Kriegstein, MD, PhD studies how embryonic neural stem cells and progenitor cells produce neurons with the goal of developing treatments for brain disorders, such as autism and Parkinson’s disease.
Publications
Molecular and spatial analysis of ganglion cells on retinal flatmounts: diversity, topography, and perivascularity.
bioRxiv : the preprint server for biology
The commitment of the human cell atlas to humanity.
Nature communications
Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease.
bioRxiv : the preprint server for biology
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Nature neuroscience
Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping.
Research square
Molecular and cellular dynamics of the developing human neocortex at single-cell resolution.
bioRxiv : the preprint server for biology
Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis.
bioRxiv : the preprint server for biology
Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping.
bioRxiv : the preprint server for biology
A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.
Proceedings of the National Academy of Sciences of the United States of America
Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus.
Science advances
Single-cell analysis of prenatal and postnatal human cortical development.
Science (New York, N.Y.)
Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.
Cell stem cell
Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism.
bioRxiv : the preprint server for biology
LIF signaling regulates outer radial glial to interneuron fate during human cortical development.
Cell stem cell
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
The Journal of clinical investigation
How mechanisms of stem cell polarity shape the human cerebral cortex.
Nature reviews. Neuroscience
Tropism of SARS-CoV-2 for human cortical astrocytes.
Proceedings of the National Academy of Sciences of the United States of America
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation.
Stem cell reports
ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
Pain
Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
Science (New York, N.Y.)
Challenges of Organoid Research.
Annual review of neuroscience
Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
The EMBO journal
Distinct nuclear compartment-associated genome architecture in the developing mammalian brain.
Nature neuroscience
Human intermediate progenitor diversity during cortical development.
Proceedings of the National Academy of Sciences of the United States of America
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.
Nature neuroscience
Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes.
bioRxiv : the preprint server for biology
Mitochondria Control Cortical Cell Fate after Mitosis.
Developmental cell
Are Organoids Ready for Prime Time?
Cell stem cell
Identification of amygdala-expressed genes associated with autism spectrum disorder.
Molecular autism
Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor.
Cell reports
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.
Cell reports
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
Cell stem cell
The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.
Cancer discovery
New insights into the development of the human cerebral cortex.
Journal of anatomy
Immature excitatory neurons develop during adolescence in the human amygdala.
Nature communications
Single-cell genomics identifies cell type-specific molecular changes in autism.
Science (New York, N.Y.)
Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.
Neuron
Shared and derived features of cellular diversity in the human cerebral cortex.
Current opinion in neurobiology
Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing.
Journal of anatomy
Does Adult Neurogenesis Persist in the Human Hippocampus?
Cell stem cell
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.
Nature neuroscience
Identification of cell types in a mouse brain single-cell atlas using low sampling coverage.
BMC biology
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
Cerebral cortex (New York, N.Y. : 1991)
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.
Nature genetics
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.
Science (New York, N.Y.)
The Human Cell Atlas.
eLife
The use of brain organoids to investigate neural development and disease.
Nature reviews. Neuroscience
Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
Nature communications
Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
Cell stem cell
oRGs and mitotic somal translocation - a role in development and disease.
Current opinion in neurobiology
Zika virus cell tropism in the developing human brain and inhibition by azithromycin.
Proceedings of the National Academy of Sciences of the United States of America
Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.
Molecular systems biology
SCell: integrated analysis of single-cell RNA-seq data.
Bioinformatics (Oxford, England)
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells.
Cell stem cell
Neuronal Migration Dynamics in the Developing Ferret Cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A GABAergic projection from the zona incerta to cortex promotes cortical neuron development.
Science (New York, N.Y.)
The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells.
Cell stem cell
Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans.
Neurogenesis (Austin, Tex.)
Yoshiki Sasai (1962�2014).
Neuron
The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yoshiki Sasai (1962�2014).
Cell stem cell
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
Nature biotechnology
Interneurons from embryonic development to cell-based therapy.
Science (New York, N.Y.)
Axonal control of the adult neural stem cell niche.
Cell stem cell
Diverse behaviors of outer radial glia in developing ferret and human cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The dynamics of neuronal migration.
Advances in experimental medicine and biology
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences.
Nature neuroscience
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.
Cell stem cell
Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex.
Nature communications
Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity.
Developmental cell
Stem cells in the land of the rising sun: ISSCR 2012.
Cell stem cell
OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease.
Current opinion in neurobiology
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.
Neuron
A new subtype of progenitor cell in the mouse embryonic neocortex.
Nature neuroscience
Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells.
Nature neuroscience
Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits.
Cerebral cortex (New York, N.Y. : 1991)
Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats.
Cell stem cell
Research ethics. NIH guidelines for stem cell research and gamete donors.
Science (New York, N.Y.)
Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.
Cell stem cell
A stem cell niche for intermediate progenitor cells of the embryonic cortex.
Cerebral cortex (New York, N.Y. : 1991)
Commentary: the prospect of cell-based therapy for epilepsy.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concerns.
Cell stem cell
Defining the role of GABA in cortical development.
The Journal of physiology
The glial nature of embryonic and adult neural stem cells.
Annual review of neuroscience
Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development.
Proceedings of the National Academy of Sciences of the United States of America
GABA regulates stem cell proliferation before nervous system formation.
Epilepsy currents
Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation.
Molecular and cellular neurosciences
GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Manipulating midbrain stem cell self-renewal.
Cell stem cell
Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis.
The Journal of comparative neurology
Gap junctions: multifaceted regulators of embryonic cortical development.
Trends in neurosciences
Clinical trials in stem cell transplantation: guidelines for scientific and ethical review.
Clinical trials (London, England)
Cortical neurogenesis: transitioning from advances in the laboratory to cell-based therapies.
Journal of visualized experiments : JoVE
In utero intraventricular injection and electroporation of E15 mouse embryos.
Journal of visualized experiments : JoVE
In utero intraventricular injection and electroporation of E16 rat embryos.
Journal of visualized experiments : JoVE
Organotypic slice culture of E18 rat brains.
Journal of visualized experiments : JoVE
Contribution of intermediate progenitor cells to cortical histogenesis.
Archives of neurology
Neural stem and progenitor cells in cortical development.
Novartis Foundation symposium
Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex.
The European journal of neuroscience
Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion.
Nature reviews. Neuroscience
Characterization of mice with targeted deletion of glycine receptor alpha 2.
Molecular and cellular biology
Progress in corticogenesis.
Cerebral cortex (New York, N.Y. : 1991)
The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex.
Cerebral cortex (New York, N.Y. : 1991)
The temporal and spatial origins of cortical interneurons predict their physiological subtype.
Neuron
A new era in the ethics of human embryonic stem cell research.
Stem cells (Dayton, Ohio)
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages.
The Journal of cell biology
GABA puts the brake on stem cells.
Nature neuroscience
Controlling neuron number: does Numb do the math?
Nature neuroscience
Patterns of neuronal migration in the embryonic cortex.
Trends in neurosciences
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases.
Nature neuroscience
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors.
The Journal of biological chemistry
Changing concepts of cortical development.
Cerebral cortex (New York, N.Y. : 1991)
Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration.
Cerebral cortex (New York, N.Y. : 1991)
Neurons from radial glia: the consequences of asymmetric inheritance.
Current opinion in neurobiology
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.
Epilepsia
Is there more to GABA than synaptic inhibition?
Nature reviews. Neuroscience
Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
GABA may act as a self-limiting trophic factor at developing synapses.
Science's STKE : signal transduction knowledge environment
Maturation of channels and receptors: consequences for excitability.
International review of neurobiology
Extrinsic GABAergic innervation of developing neocortical layer 1 in organotypic slice co-cultures.
The Journal of comparative neurology
An excitatory GABAergic plexus in developing neocortical layer 1.
Journal of neurophysiology
Calcium dynamics of neocortical ventricular zone cells.
Developmental neuroscience
Leukoencephalopathy and raised brain lactate from heroin vapor inhalation ("chasing the dragon")
Neurology
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations.
Proceedings of the National Academy of Sciences of the United States of America
Changing properties of GABA(A) receptor-mediated signaling during early neocortical development.
Journal of neurophysiology
Ontogeny of channels, transmitters and epileptogenesis.
Advances in neurology
Patterns of intracellular calcium fluctuation in precursor cells of the neocortical ventricular zone.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Postnatal development of low [Mg2+] oscillations in neocortex.
Journal of neurophysiology
Cell coupling and uncoupling in the ventricular zone of developing neocortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mechanisms underlying neuronal migration disorders and epilepsy.
Current opinion in neurology
NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Heroin inhalation and progressive spongiform leukoencephalopathy.
The New England journal of medicine
Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cortical neurogenesis and its disorders.
Current opinion in neurology
Properties of amino acid neurotransmitter receptors of embryonic cortical neurons when activated by exogenous and endogenous agonists.
Journal of neurophysiology
Norepinephrine activates potassium conductance in neurons of the turtle cerebral cortex.
Brain research
Spontaneous action potential activity and synaptic currents in the embryonic turtle cerebral cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Appearance of putative amino acid neurotransmitters during differentiation of neurons in embryonic turtle cerebral cortex.
The Journal of comparative neurology
Morphological differentiation of distinct neuronal classes in embryonic turtle cerebral cortex.
The Journal of comparative neurology
Clusters of coupled neuroblasts in embryonic neocortex.
Science (New York, N.Y.)
Initial expression and endogenous activation of NMDA channels in early neocortical development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Turtle cortical neurons survive glutamate exposures that are lethal to mammalian neurons.
Brain research
Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex.
Proceedings of the National Academy of Sciences of the United States of America
Differential activation of glutamate receptors by spontaneously released transmitter in slices of neocortex.
Neuroscience letters
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex.
Journal of neuroscience methods
The development of bicuculline-induced epileptiform discharges in embryonic turtle cortex.
Neuroscience letters
Development of GABA responsiveness in embryonic turtle cortical neurons.
Neuroscience letters
Quantitative autoradiography of muscarinic and benzodiazepine receptors in the forebrain of the turtle, Pseudemys scripta.
The Journal of comparative neurology
Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitro.
Brain research
Synaptic responses of cortical pyramidal neurons to light stimulation in the isolated turtle visual system.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Evidence for the inhibitory neurotransmitter gamma-aminobutyric acid in aspiny and sparsely spiny nonpyramidal neurons of the turtle dorsal cortex.
The Journal of comparative neurology
Glutamate neurotoxicity in cortical cell culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Monoclonal antibodies to the turtle cortex reveal neuronal subsets, antigenic cross-reactivity with the mammalian neocortex, and forebrain structures sharing a pallial derivation.
The Journal of comparative neurology
Turtle hippocampal cortex contains distinct cell types, burst-firing neurons, and an epileptogenic subfield.
Journal of neurophysiology
Cellular physiology of the turtle visual cortex: distinctive properties of pyramidal and stellate neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cellular physiology of the turtle visual cortex: synaptic properties and intrinsic circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The influence of dopamine on epileptiform burst activity in hippocampal pyramidal neurons.
Brain research
Morphological classification of rat cortical neurons in cell culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cholinergic enhancement of penicillin-induced epileptiform discharges in pyramidal neurons of the guinea pig hippocampus.
Brain research
Neurology-important advances in clinical medicine: treatment of febrile convulsions.
The Western journal of medicine
Stages in the post-hatching development of Aplysia californica.
The Journal of experimental zoology
Development of the nervous system of Aplysia californica.
Proceedings of the National Academy of Sciences of the United States of America
Metamorphosis of Aplysia californica in laboratory culture.
Proceedings of the National Academy of Sciences of the United States of America