Aras Mattis, MD, PhD

Associate Professor
Pathology
+1 415 514-3062

Aras Mattis, MD, PhD, investigates the molecular mechanisms of human liver function and metabolic diseases like metabolic dysfunction-associated steatotic liver disease (MASLD). The Mattis lab develops human induced pluripotent stem cells that are then differentiated into multiple liver cell types including human hepatocyte-like cells (iPSC-derived hepatocytes) to develop models of this disease process. The laboratory is also interested in normal liver development.

Publications

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.

Science translational medicine

Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY