
Professor
Cell and Tissue Biology
+1 415 353-7070
Andrei Goga, MD, PhD uses mouse models to study basic cell cycle regulation in normal and tumor cells in order to facilitate the development of cell cycle inhibitors as potential therapeutics.
Publications
Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury.
bioRxiv : the preprint server for biology
Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway.
Cell reports. Medicine
Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling.
bioRxiv : the preprint server for biology
Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes.
The Journal of clinical investigation
Respiratory complex I regulates dendritic cell maturation in explant model of human tumor immune microenvironment.
Journal for immunotherapy of cancer
Changes in spindle morphology driven by TPX2 overexpression in MYC-driven breast cancer cells.
microPublication biology
An inflamed tumor cell subpopulation promotes chemotherapy resistance in triple negative breast cancer.
Scientific reports
The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
bioRxiv : the preprint server for biology
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Nature cell biology
Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Nature communications
Deep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models.
Breast cancer research : BCR
Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
Nature microbiology
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Nature communications
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
Nature chemical biology
NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
Translational oncology
Evaluation of disseminated tumor cells and circulating tumor cells in patients with breast cancer receiving adjuvant zoledronic acid.
NPJ breast cancer
Oncogene-regulated release of extracellular vesicles.
Developmental cell
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.
Journal of hepatology
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.
Nature medicine
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
Gastroenterology
Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.
Nature chemical biology
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.
Nature communications
Comprehensive analysis of normal adjacent to tumor transcriptomes.
Nature communications
Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model.
Magnetic resonance imaging
In vivo Reprogramming of Cancer Metabolism by MYC.
Frontiers in cell and developmental biology
Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling.
Proceedings of the National Academy of Sciences of the United States of America
MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.
EMBO reports
Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.
Magnetic resonance imaging
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.
Nature medicine
Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.
ACS chemical biology
GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.
Cell chemical biology
Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.
Nature medicine
Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
Current biology : CB
Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.
Human molecular genetics
Biogenesis, delivery, and function of extracellular RNA.
Journal of extracellular vesicles
Identification of Chemical Inhibitors of �-Catenin-Driven Liver Tumorigenesis in Zebrafish.
PLoS genetics
Direct and indirect targeting of MYC to treat acute myeloid leukemia.
Cancer chemotherapy and pharmacology
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
ACS chemical biology
CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Stem cell reports
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
Cancer discovery
Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.
ACS chemical biology
Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Taking on challenging targets: making MYC druggable.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Cancer discovery
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.
Hepatology (Baltimore, Md.)
Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.
Magnetic resonance in medicine
HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells.
The Biochemical journal
IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Science (New York, N.Y.)
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
Proceedings of the National Academy of Sciences of the United States of America
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
The Journal of experimental medicine
Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.
Magnetic resonance imaging
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
Cell metabolism
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
Molecular cell
Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.
Science translational medicine
Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.
Journal of magnetic resonance imaging : JMRI
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
Nature medicine
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase.
Proceedings of the National Academy of Sciences of the United States of America
Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.
Proceedings of the National Academy of Sciences of the United States of America
3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer.
Magnetic resonance in medicine
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.
The Journal of biological chemistry
A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons.
Neuron
Anti-oncomir suppression of tumor phenotypes.
Molecular interventions
Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b.
The Journal of biological chemistry
RNA interference (RNAi) with RNase III-prepared siRNAs.
Methods in molecular biology (Clifton, N.J.)
Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.
Molecular and cellular biology
Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America
Differential complementation of Bcr-Abl point mutants with c-Myc.
Science (New York, N.Y.)
Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL.
Cold Spring Harbor symposia on quantitative biology
Oncogenic activation of c-ABL by mutation within its last exon.
Molecular and cellular biology