
Associate Professor
Pediatrics
Alice Chan, MD, PhD studies pathways of immune development and regulation in the context of pediatric immune regulatory disorders.
Publications
A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.
The Journal of experimental medicine
The autoimmune targets in IPEX are dominated by gut epithelial proteins.
The Journal of allergy and clinical immunology
A large CRISPR-induced bystander mutation causes immune dysregulation.
Communications biology
Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation.
Nature
Exome Sequencing Reveals Mutations in AIRE as a Cause of Isolated Hypoparathyroidism.
The Journal of clinical endocrinology and metabolism
Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders.
The Journal of allergy and clinical immunology
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
The Journal of experimental medicine
Central tolerance to self revealed by the autoimmune regulator.
Annals of the New York Academy of Sciences
B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation.
Journal of clinical immunology
Treatment of juvenile idiopathic arthritis.
Pediatric annals
Early vs. delayed diagnosis of severe combined immunodeficiency: a family perspective survey.
Clinical immunology (Orlando, Fla.)
Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP.
Journal of autoimmunity
The role of SAP and the SLAM family in autoimmunity.
Current opinion in immunology