
Associate Professor
Anatomy
+1 415 502-1929
Saul Villeda, PhD studies how molecular immune-related changes in old blood impair stem cell function and cognitive processes in the brain during aging, and conversely how young blood can reverse these impairments.
Publications
306 Characterization of Systemic and Local Mediators Driving Osteoarthritis and Multi-Organ Aging.
Journal of Pain
Halt aging? - functional HSCs lead the way.
Cell research
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
Brain communications
MICROGLIA AGING IN THE HIPPOCAMPUS ADVANCES THROUGH INTERMEDIATE STATES THAT DRIVE INFLAMMATORY ACTIVATION AND COGNITIVE DECLINE.
bioRxiv : the preprint server for biology
Systemic Mechanisms of Brain Aging and Rejuvenation.
Alzheimer's & Dementia
Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration.
bioRxiv : the preprint server for biology
Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex.
bioRxiv : the preprint server for biology
Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice.
Molecular therapy : the journal of the American Society of Gene Therapy
Plasma rejuvenation factor GDF11 associates with amyloid-related cognitive decline in older adults across the Alzheimer’s Disease spectrum.
Alzheimer's & Dementia
Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females.
bioRxiv : the preprint server for biology
Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species.
Cell reports
Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.
Nature aging
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice.
Nature communications
Pain and Itch Processing in Aged Mice.
The journal of pain
The platelet transcriptome and proteome in Alzheimer's disease and aging: an exploratory cross-sectional study.
Frontiers in molecular biosciences
Neurobiology of Aging: New Insights From Across the Research Spectrum.
The journals of gerontology. Series A, Biological sciences and medical sciences
Blood-to-brain communication in aging and rejuvenation.
Nature neuroscience
Reply to 'Lactate as a major myokine and exerkine'.
Nature reviews. Endocrinology
Corrigendum: Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury.
Frontiers in neurology
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.
Science advances
Exerkines in health, resilience and disease.
Nature reviews. Endocrinology
SYSTEMIC MECHANISMS OF BRAIN REJUVENATION.
Innovation in Aging
MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling.
PLoS biology
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
O27: MICROGLIAL CORRECTION AFTER FETAL THERAPY WITHOUT CONDITIONING IN MICE WITH MUCOPOLYSACCHARIDOSIS TYPE VII.
British Journal of Surgery
Cognitive Aging: New Insights Into How Our Brains Age.
Innovation in Aging
Regeneration and Cognition in Aging.
Innovation in Aging
Dampening the Power of the Brain-When Aging Meets Cognition.
The journals of gerontology. Series A, Biological sciences and medical sciences
Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.
Proceedings of the National Academy of Sciences of the United States of America
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
Science (New York, N.Y.)
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.
Nature metabolism
Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII.
Science translational medicine
OPCs on a Diet: A Youthful Serving of Remyelination.
Cell metabolism
MECHANISMS OF BRAIN REJUVENATION.
Innovation in Aging
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.
Current biology : CB
Innovative approaches in cognitive aging.
Neurobiology of aging
Platelets Give a Running Start to Adult Hippocampal Neurogenesis.
Stem cell reports
Fetal enzyme replacement and stem cell transplantation in murine Sly syndrome targeting microglia.
Molecular genetics and metabolism
MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage.
Nature metabolism
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration.
Molecular neurodegeneration
Hematopoietic Stem Cell Transplantation Using a Non-Toxic Regimen to Ablate the Fetal Bone Marrow Niche Enables Engraftment of Brain Microglial Cells.
Journal of the American College of Surgeons
1021 Origin of type 2 innate lymphoid cells in the skin.
Journal of Investigative Dermatology
Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.
Cell reports
The systemic environment: at the interface of aging and adult neurogenesis.
Cell and tissue research
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.
Nature communications
Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease.
F1000Research
Mechanisms of Hippocampal Aging and the Potential for Rejuvenation.
Annual review of neuroscience
Microglia communication: Parallels between aging and Alzheimer's disease.
Clinical & experimental neuroimmunology
Translational strategies in aging and age-related disease.
Nature medicine
Fat Chance for Neural Stem Cells in Alzheimer's Disease.
Cell stem cell
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.
Nature medicine
Aging and brain rejuvenation as systemic events.
Journal of neurochemistry
ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.
Nature neuroscience
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.
Nature medicine
Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury.
Frontiers in neurology
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival.
The Journal of experimental medicine
The circulatory systemic environment as a modulator of neurogenesis and brain aging.
Autoimmunity reviews
Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
FoxO3 regulates neural stem cell homeostasis.
Cell stem cell
Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord.
Neuroscience
Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cord.
The Journal of comparative neurology