
Professor
Anesthesia
+1 415 476-0141
Hua Su, MD studies gene and cell based therapies for cerebral vascular diseases, including stroke.
Publications
Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy.
Translational stroke research
Evaluation of Aav Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy.
Research square
ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke.
Clinical and translational medicine
CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation.
Research square
Cellular loci involved in the development of brain arteriovenous malformations.
Frontiers in human neuroscience
Potential Targets for the Treatment of Brain Arteriovenous Malformations.
Translational stroke research
N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.
Journal of neuroinflammation
Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain Arteriovenous Malformations in Mice.
Translational stroke research
Somatic mosaicism in the MAPK pathway in sporadic brain arteriovenous malformation and association with phenotype.
Journal of neurosurgery
Review of treatment and therapeutic targets in brain arteriovenous malformation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation.
BMJ neurology open
Reduction of neuroinflammation alleviated mouse post bone fracture and stroke memory dysfunction.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice
International Journal of Molecular Science.
Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice.
International journal of molecular sciences
Reduction of endoglin receptor impairs mononuclear cell-migration.
Exploration of medicine
Concurrent Presentation of Brain Arteriovenous Malformation, Peripheral Arteriovenous Malformation, and Cerebellar Astrocytoma: Case report.
Interdisciplinary Neurosurgery
Concurrent presentation of brain arteriovenous malformation, peripheral arteriovenous malformation, and cerebellar astrocytoma: Case report.
Interdisciplinary neurosurgery : Advanced techniques and case management
Recent Advances in Basic Research for Brain Arteriovenous Malformation.
International journal of molecular sciences
Risk factors for hemorrhage of brain arteriovenous malformation.
CNS neuroscience & therapeutics
Effect of elevation of vascular endothelial growth factor level on exacerbation of hemorrhage in mouse brain arteriovenous malformation.
Journal of neurosurgery
Abstract TMP105: Elevation of VEGF Exacerbates Hemorrhage in Mouse Brain Arteriovenous Malformation.
Stroke
Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice.
Translational stroke research
Risk factors for ischemic stroke post bone fracture.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Impact of Bone Fracture on Ischemic Stroke Recovery.
International journal of molecular sciences
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway.
Aging and disease
Animal Models and Prospective Therapeutic Targets for Brain Arteriovenous Malformation.
Molecular, Genetic, and Cellular Advances in Cerebrovascular Diseases
Reductions in brain pericytes are associated with arteriovenous malformation vascular instability.
Journal of neurosurgery
Inflammation and genetic factors in stroke pathogenesis.
Neuroimmunology and neuroinflammation
The roles of endoglin gene in cerebrovascular diseases.
Neuroimmunology and neuroinflammation
Endovascular Biopsy: In Vivo Cerebral Aneurysm Endothelial Cell Sampling and Gene Expression Analysis.
Translational stroke research
381 Reductions in Brain Pericytes are Associated with Arteriovenous Malformation Vascular Instability.
Neurosurgery
Morbidity after Hemorrhage in Children with Untreated Brain Arteriovenous Malformation.
Cerebrovascular diseases (Basel, Switzerland)
Gene Therapy for Stroke.
Translational Research in Stroke
Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.
Molecular neurobiology
Correction: Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice.
PloS one
Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.
Translational stroke research
Carnosic Acid Prevents Beta-Amyloid-Induced Injury in Human Neuroblastoma SH-SY5Y Cells via the Induction of Autophagy.
Neurochemical research
Morphometric characterization of brain arteriovenous malformations for clinical and radiological studies to identify silent intralesional microhemorrhages.
Clinical neuropathology
SIRT3 Acts as a Neuroprotective Agent in Rotenone-Induced Parkinson Cell Model.
Neurochemical research
Impact and risk factors of post-stroke bone fracture.
World journal of experimental medicine
Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation.
Acta neurochirurgica. Supplement
Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels✩.
Biotechnology reports (Amsterdam, Netherlands)
Review
The role of macrophage in the pathogenesis of brain arteriovenous malformation
Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1.
Gene therapy
385. Intravenous Delivery of AAV9-CMV-sFLT1 Reduces the Severity of Brain Arteriovenous Malformation Without Causing Significant Side Effects in a Mouse Model.
Molecular Therapy
Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model.
Interventional Neuroradiology
Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells
Transl Stroke Res.2015 Feb;6(1):50-59.
Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis.
Journal of visualized experiments : JoVE
Endovascular Biopsy: Technical Feasibility of Novel Endothelial Cell Harvesting Devices Assessed in a Rabbit Aneurysm Model.
Interventional Neuroradiology
Endovascular treatment of severe acute basilar artery occlusion
J Clin Neurosci
Targeted Gene Therapy for Ischemic Stroke.
Gene Delivery and Therapy for Neurological Disorders
The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation.
International journal of hematology research
Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting.
Journal of biotechnology
Distinctive distribution of lymphocytes in unruptured and previously untreated brain arterviovenous malformation
Neuroimmunology and neuroinflammation
Endovascular treatment of severe acute basilar artery occlusion.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture.
Journal of neurochemistry
Brain arteriovenous malformation modeling, pathogenesis, and novel therapeutic targets.
Translational stroke research
Development of the central nervous system vasculature and the pathogenesis of brain arteriovenous malformations.
Comprehensive Management of Arteriovenous Malformations of the Brain and Spine
Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation.
Neuroimmunology and neuroinflammation
ERRATUM TO: Induction of Brain Arteriovenous Malformation in the Adult Mouse.
Cerebral Angiogenesis
Induction of brain arteriovenous malformation in the adult mouse.
Methods in molecular biology (Clifton, N.J.)
Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
Bone fracture exacerbates murine ischemic cerebral injury.
Anesthesiology
Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain.
Arteriosclerosis, thrombosis, and vascular biology
Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation.
Translational stroke research
Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.
Cerebrovascular diseases (Basel, Switzerland)
Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture.
Stroke
Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis.
Journal of visualized experiments : JoVE
Cerebrovascular casting of the adult mouse for 3D imaging and morphological analysis.
Journal of visualized experiments : JoVE
Oligogenesis and oligodendrocyte progenitor maturation vary in different brain regions and partially correlate with local angiogenesis after ischemic stroke.
Translational stroke research
Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Arteriovenous malformation in the adult mouse brain resembling the human disease.
Annals of neurology
Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm.
Acta neurochirurgica. Supplement
Treatment of focal brain ischemia with viral vector-mediated gene transfer.
Methods in molecular biology (Clifton, N.J.)
Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124.
Science (New York, N.Y.)
Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations.
Neurosurgery
VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice.
Translational stroke research
MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors.
Cell stem cell
Endothelial progenitor cell transplantation improves long-term stroke outcome in mice.
Annals of neurology
Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.
The American journal of pathology
Combining angiogenic gene and stem cell therapies for myocardial infarction.
The journal of gene medicine
Soluble endoglin modulates aberrant cerebral vascular remodeling.
Annals of neurology
Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain.
Journal of neuropathology and experimental neurology
Nonischemic cerebral venous hypertension promotes a pro-angiogenic stage through HIF-1 downstream genes and leukocyte-derived MMP-9.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.
American journal of physiology. Heart and circulatory physiology
Contribution of bone marrow-derived cells associated with brain angiogenesis is primarily through leukocytes and macrophages.
Arteriosclerosis, thrombosis, and vascular biology
VEGF improves survival of mesenchymal stem cells in infarcted hearts.
Biochemical and biophysical research communications
Overexpression of netrin-1 induces neovascularization in the adult mouse brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart.
International journal of cardiology
AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid.
The journal of gene medicine
Development of a cerebral microvascular dysplasia model in rodents.
Acta neurochirurgica. Supplement
Establishing a novel single-copy primer-internal intron-spanning PCR (spiPCR) procedure for the direct detection of gene doping.
Exercise immunology review
Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations.
Acta neurochirurgica. Supplement
Neutrophil depletion decreases VEGF-induced focal angiogenesis in the mature mouse brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Adeno-Associated Viral Vector-Delivered Hypoxia-Inducible Gene Expression in Ischemic Hearts.
Cardiac Gene Expression
Adeno-associated viral vector-delivered hypoxia-inducible gene expression in ischemic hearts.
Methods in molecular biology (Clifton, N.J.)
Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain.
Frontiers in bioscience : a journal and virtual library
AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect.
Gene therapy
228. AAV Mediated Hypoxia-Inducible VEGF Expression and Neovascular Formation in Ischemic Pig Myocardium.
Molecular Therapy
343. Vascular Endothelial Growth Factor Prevents Bone Marrow Derived-Mesenchymal Stem Cell Senescence In Vitro.
Molecular Therapy
Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts.
Proceedings of the National Academy of Sciences of the United States of America
Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb.
Molecular therapy : the journal of the American Society of Gene Therapy
Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model.
Proceedings of the National Academy of Sciences of the United States of America
Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart.
Proceedings of the National Academy of Sciences of the United States of America
Adeno-associated viral-mediated gene transfer to hepatoma: thymidine kinase/interleukin 2 is more effective in tumor killing in non-ganciclovir (GCV)-treated than in GCV-treated animals.
Molecular therapy : the journal of the American Society of Gene Therapy
Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice.
Proceedings of the National Academy of Sciences of the United States of America
Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex.
The Journal of cell biology
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene.
Human gene therapy
Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach.
American journal of human genetics
Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies.
Molecular reproduction and development
Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen.
Journal of reproductive immunology