Dean Sheppard, MD | Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF

Stromal heterogeneity in the adult lung delineated by single-cell genomics.

American journal of physiology. Cell physiology

Tsukui T, Sheppard D

Dual αVβ8 Integrin and PD-1 Blockade Overcomes TGFβ-Mediated B-Cell Suppression to Enhance Anti-Glioma Immunity.

Neuro-oncology

Hou D, Wang S, Castro BA, Katz JL, Dapash M, Arrieta VA, Vazquez-Cervantes GI, Wan H, Billingham LK, Du R, Murphy AR, Lopez-Rosas A, Han Y, Patel RV, Chia TY, Dmello CC, Zhang P, Sheppard D, Sonabend AM, Miska JM, Lesniak MS, Heiland DH, Lee-Chang C

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium.

Genome medicine

Neumann A, Sammallahti S, Cosin-Tomas M, Reese SE, Suderman M, Alemany S, Almqvist C, Andrusaityte S, Arshad SH, Bakermans-Kranenburg MJ, Beilin L, Breton C, Bustamante M, Czamara D, Dabelea D, Eng C, Eskenazi B, Fuemmeler BF, Gilliland FD, Grazuleviciene R, Håberg SE, Herberth G, Holland N, Hough A, Hu D, Huen K, Hüls A, Jarvelin MR, Jin J, Julvez J, Koletzko BV, Koppelman GH, Kull I, Lu X, Maitre L, Mason D, Melén E, Merid SK, Molloy PL, Mori TA, Mulder RH, Page CM, Richmond RC, Röder S, Ross JP, Schellhas L, Sebert S, Sheppard D, Snieder H, Starling AP, Stein DJ, Tindula G, van IJzendoorn MH, Vonk J, Walton E, Witonsky J, Xu CJ, Yang IV, Yousefi PD, Zar HJ, Zenclussen AC, Zhang H, Tiemeier H, London SJ, Felix JF, Cecil C

Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity.

Nature communications

McKinsey GL, Santander N, Zhang X, Kleemann KL, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama CO, La Russa M, Koo JH, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD

ATF4 drives regulatory T cell functional specification in homeostasis and obesity.

Science immunology

Wang K, Farrell A, Zhou E, Qin H, Zeng Z, Zhou K, Cunha E Rocha K, Zhang D, Wang G, Atakilit A, Sheppard D, Lu LF, Jin C, Ying W

Independent and interactive effects of viral species on risk for lower respiratory tract illnesses in early life.

medRxiv : the preprint server for health sciences

Moore CM, Secor EA, Fairbanks-Mahnke A, Everman JL, Elhawary JR, Witonsky JI, Pruesse E, Chang CH, Contreras MG, Eng C, Canales K, Rosado T, Hu D, Huntsman S, Jackson ND, Li Y, Lopez N, Valentin AM, Medina V, Montanez-Lopez CA, Morin A, Nieves NA, Oh SS, Otero RA, Colon R, Rodriguez L, Sajuthi SP, Salazar S, Serrano G, Morales EV, Vazquez G, Morales NV, Williams BJM, Zhang P, Sheppard D, Rodriguez Santana JR, Seibold MA

RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition.

Nature

Fang Y, Chung SSW, Xu L, Xue C, Liu X, Jiang D, Li R, Korogi Y, Yuan K, Saqi A, Hibshoosh H, Huang Y, Lin CS, Tsukui T, Sheppard D, Sun X, Que J

Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.

The Journal of clinical investigation

Kumar R, Nolan K, Kassa B, Chanana N, Palmo T, Sharma K, Singh K, Mickael C, Fonseca Balladares D, Nilsson J, Prabhakar A, Mishra A, Lee MH, Sanders L, Kumar S, Molofsky AB, Stenmark KR, Sheppard D, Tuder RM, Gupta MD, Thinlas T, Pasha Q, Graham BB

Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification.

eLife

Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D

Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.

bioRxiv : the preprint server for biology

Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D

IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.

Proceedings of the National Academy of Sciences of the United States of America

Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB

Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading.

bioRxiv : the preprint server for biology

Yadav P, Ortega JG, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Wolters PJ, Tamaki SJ, Bivona T, Abate AR, Wagner A, Tharp KM, Bhattacharya M

Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis.

Nature

Tsukui T, Wolters PJ, Sheppard D

IL-13 and IL-17A Activate β1 Integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to Enhance Force Transmission in Airway Smooth Muscle.

bioRxiv : the preprint server for biology

Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB

The Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes (PRIMERO): Design and Baseline Characteristics for a Birth Cohort Study of Early-life Viral Respiratory Illnesses and Airway Dysfunction in Puerto Rican Children.

medRxiv : the preprint server for health sciences

Witonsky JI, Elhawary JR, Eng C, Oh SS, Salazar S, Contreras MG, Medina V, Secor EA, Zhang P, Everman JL, Fairbanks-Mahnke A, Pruesse E, Sajuthi SP, Chang CH, Guerrero TR, Fuentes KC, Lopez N, Montanez-Lopez CA, Otero RA, Rivera RC, Rodriguez L, Vazquez G, Hu D, Huntsman S, Jackson ND, Li Y, Morin A, Nieves NA, Rios C, Serrano G, Williams BJM, Ziv E, Moore CM, Sheppard D, Burchard EG, Seibold MA, Rodriguez Santana JR

Dynamic fibroblast-immune interactions shape wound healing after brain injury.

bioRxiv : the preprint server for biology

Ewing-Crystal NA, Mroz NM, Chang AA, Merrill ED, Caryotakis SE, Teo L, Larpthaveesarp A, Tsukui T, Katewa A, Pennington R, McKinsey GL, Nelson S, Ciesielska A, Dahlgren MW, Paidassi H, Jain S, Aghi MK, Bourne JA, Paz JT, Gonzalez FF, Sheppard D, Molofsky AV, Arnold TD, Molofsky AB

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.

The Journal of clinical investigation

Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T

Mast cells help organize the Peyer's patch niche for induction of IgA responses.

Science immunology

De Giovanni M, Vykunta VS, Biram A, Chen KY, Taglinao H, An J, Sheppard D, Paidassi H, Cyster JG

Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report.

Annals of the American Thoracic Society

Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Konigshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, Raju SV, Petrache I, Watkins T, Kumar R, Lam WA, Sherer T, Hecker L

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.

Nature immunology

Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O

Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling.

bioRxiv : the preprint server for biology

McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD

TGF-β signaling in health and disease.

Cell

Massagué J, Sheppard D

An immune-based tool platform for in vivo cell clearance.

Life science alliance

Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL

An integrated cell atlas of the lung in health and disease.

Nature medicine

Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung MI, Collin A, Gay ACA, Gote-Schniering J, Hooshiar Kashani B, Inecik K, Jain M, Kapellos TS, Kole TM, Leroy S, Mayr CH, Oliver AJ, von Papen M, Peter L, Taylor CJ, Walzthoeni T, Xu C, Bui LT, De Donno C, Dony L, Faiz A, Guo M, Gutierrez AJ, Heumos L, Huang N, Ibarra IL, Jackson ND, Kadur Lakshminarasimha Murthy P, Lotfollahi M, Tabib T, Talavera-López C, Travaglini KJ, Wilbrey-Clark A, Worlock KB, Yoshida M, Lung Biological Network Consortium, van den Berge M, Bossé Y, Desai TJ, Eickelberg O, Kaminski N, Krasnow MA, Lafyatis R, Nikolic MZ, Powell JE, Rajagopal J, Rojas M, Rozenblatt-Rosen O, Seibold MA, Sheppard D, Shepherd DP, Sin DD, Timens W, Tsankov AM, Whitsett J, Xu Y, Banovich NE, Barbry P, Duong TE, Falk CS, Meyer KB, Kropski JA, Pe'er D, Schiller HB, Tata PR, Schultze JL, Teichmann SA, Misharin AV, Nawijn MC, Luecken MD, Theis FJ

Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis.

Gastroenterology

Livanos AE, Dunn A, Fischer J, Ungaro RC, Turpin W, Lee SH, Rui S, Del Valle DM, Jougon JJ, Martinez-Delgado G, Riddle MS, Murray JA, Laird RM, Torres J, Agrawal M, Magee JS, Dervieux T, Gnjatic S, Sheppard D, Sands BE, Porter CK, Croitoru K, Petralia F, CCC-GEM Project Research Consortium, OSCCAR Consortium, Colombel JF, Mehandru S

A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins.

International journal of biological sciences

Monieri M, Rainone P, Sacchi A, Gori A, Gasparri AM, Coliva A, Citro A, Ferrara B, Policardi M, Valtorta S, Pocaterra A, Alfano M, Sheppard D, Piemonti L, Moresco RM, Corti A, Curnis F

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.

Science (New York, N.Y.)

Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T

Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury.

Frontiers in immunology

Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M

Obesity alters pathology and treatment response in inflammatory disease.

Nature

Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR

αVβ8 integrin targeting to prevent posterior capsular opacification.

JCI insight

Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK

Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.

Nature communications

Lainé A, Labiad O, Hernandez-Vargas H, This S, Sanlaville A, Léon S, Dalle S, Sheppard D, Travis MA, Paidassi H, Marie JC

Integrin av�8 on T�cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.

Cell reports

Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D

Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

The Journal of clinical investigation

Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

American journal of respiratory and critical care medicine

Auyeung VC, Sheppard D

Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis.

The Journal of pathology

Nishimichi N, Tsujino K, Kanno K, Sentani K, Kobayashi T, Chayama K, Sheppard D, Yokosaki Y

KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.

JCI insight

Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.

Nature cell biology

Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T

Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.

Bioorganic & medicinal chemistry letters

Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.

Science translational medicine

Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY

Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.

The Journal of clinical investigation

Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.

Nature communications

Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D

Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking.

Science advances

Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.

The Journal of biological chemistry

Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB

Impaired aV�8 and TGF� signaling lead to microglial dysmaturation and neuromotor dysfunction.

The Journal of experimental medicine

Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D

β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.

International journal of cancer

Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M

IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility.

Journal of immunology (Baltimore, Md. : 1950)

Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.

PloS one

Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR

Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.

The American journal of pathology

Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC

Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.

JCI insight

Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M

Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.

American journal of physiology. Lung cellular and molecular physiology

Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K

TGF-β1 Signaling and Tissue Fibrosis.

Cold Spring Harbor perspectives in biology

Kim KK, Sheppard D, Chapman HA

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.

Proceedings of the National Academy of Sciences of the United States of America

Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S

Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.

American journal of physiology. Lung cellular and molecular physiology

Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D

An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

American journal of respiratory cell and molecular biology

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES, ATS Assembly on Respiratory Cell and Molecular Biology

Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.

Journal of the American Society of Nephrology : JASN

Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D

Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.

The Journal of clinical investigation

Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D

Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma.

American journal of physiology. Lung cellular and molecular physiology

Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D

Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors.

ACS medicinal chemistry letters

Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.

PLoS pathogens

Meliopoulos VA, Van de Velde LA, Van de Velde NC, Karlsson EA, Neale G, Vogel P, Guy C, Sharma S, Duan S, Surman SL, Jones BG, Johnson MD, Bosio C, Jolly L, Jenkins RG, Hurwitz JL, Rosch JW, Sheppard D, Thomas PG, Murray PJ, Schultz-Cherry S

Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome.

Journal of immunology (Baltimore, Md. : 1950)

McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA, Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D, Ouyang W, Hooper LV, Kolls JK

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.

Science (New York, N.Y.)

Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG

α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Sun KH, Chang Y, Reed NI, Sheppard D

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.

Nature immunology

Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH

Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma.

Current rheumatology reports

Tsujino K, Sheppard D

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.

Hepatology (Baltimore, Md.)

Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D

The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.

Science translational medicine

Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D

Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts.

Annals of the American Thoracic Society

Sheppard D

Innate antiviral host defense attenuates TGF-� function through IRF3-mediated suppression of Smad signaling.

Molecular cell

Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aV�8-TGF� signaling in the brain.

Development (Cambridge, England)

Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.

The Journal of clinical investigation

Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D

The cell biology of asthma.

The Journal of cell biology

Erle DJ, Sheppard D

Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.

Proceedings of the National Academy of Sciences of the United States of America

Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.

American journal of physiology. Lung cellular and molecular physiology

Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

American journal of respiratory and critical care medicine

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP

TGF-β activation and function in immunity.

Annual review of immunology

Travis MA, Sheppard D

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Nature medicine

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D

Eosinophils secrete IL-4 to facilitate liver regeneration.

Proceedings of the National Academy of Sciences of the United States of America

Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

The Journal of clinical investigation

Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A

ROCKing pulmonary fibrosis.

The Journal of clinical investigation

Sheppard D

Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5.

Critical care medicine

Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D

Therapy for fibrotic diseases: nearing the starting line.

Science translational medicine

Friedman SL, Sheppard D, Duffield JS, Violette S

Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.

Proceedings of the National Academy of Sciences of the United States of America

Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ

Integrin-mediated regulation of TGFβ in fibrosis.

Biochimica et biophysica acta

Henderson NC, Sheppard D

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.

Proceedings of the National Academy of Sciences of the United States of America

Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.

The Journal of clinical investigation

Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D

Modulation of acute lung injury by integrins.

Proceedings of the American Thoracic Society

Sheppard D

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.

The Journal of experimental medicine

Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF

IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.

American journal of physiology. Lung cellular and molecular physiology

Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.

Nature medicine

Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D

Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness.

Journal of immunology (Baltimore, Md. : 1950)

Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.

Experimental cell research

Giacomini MM, Travis MA, Kudo M, Sheppard D

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

The Journal of clinical investigation

Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D

Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.

American journal of respiratory and critical care medicine

Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D

Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix.

Cold Spring Harbor perspectives in biology

Munger JS, Sheppard D

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.

Journal of immunology (Baltimore, Md. : 1950)

Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G

Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease.

International journal of rheumatology

Katsumoto TR, Violette SM, Sheppard D

Recommendations for the classification of diseases as CFTR-related disorders.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevínek P, Farrell P, Elborn JS, Jarvi K, Kerem B, Kerem E, Knowles M, Macek M, Munck A, Radojkovic D, Seia M, Sheppard DN, Southern KW, Stuhrmann M, Tullis E, Zielenski J, Pignatti PF, Ferec C

Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era.

Proceedings of the American Thoracic Society

Sheppard D

Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit.

Experimental cell research

Kon S, Atakilit A, Sheppard D

Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1.

The Journal of biological chemistry

Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y

Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling.

Molecular and cellular biology

Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, Sheppard D, Moasser MM

Expression of av�8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

The Journal of clinical investigation

Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.

The Journal of clinical investigation

Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D

beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia.

American journal of respiratory cell and molecular biology

Hogmalm A, Sheppard D, Lappalainen U, Bry K

Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.

Developmental cell

Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T

Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.

The Journal of biological chemistry

Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.

Blood

Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

The American journal of pathology

Xu MY, Porte J, Knox AJ, Weinreb PH, Maher TM, Violette SM, McAnulty RJ, Sheppard D, Jenkins G

Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing.

The Journal of investigative dermatology

Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L

The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.

Proceedings of the National Academy of Sciences of the United States of America

deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D

Dust mites' dirty dealings with dendritic cells.

Nature medicine

Sheppard D

Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.

The American journal of pathology

Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L

Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.

Circulation research

Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF

An essential role for fibronectin extra type III domain A in pulmonary fibrosis.

American journal of respiratory and critical care medicine

Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.

The Journal of clinical investigation

Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.

American journal of respiratory and critical care medicine

Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, Violette SM

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

Nature

Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D

Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.

American journal of respiratory cell and molecular biology

Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG

Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC

Genomics and proteomics of lung disease: conference summary.

American journal of physiology. Lung cellular and molecular physiology

Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA

Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis.

The Journal of biological chemistry

Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D

Roles of the innate immune system in mammary gland remodeling during involution.

Journal of mammary gland biology and neoplasia

Atabai K, Sheppard D, Werb Z

Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

The American journal of pathology

Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A, Kalluri R, Shield CF, Sheppard D, Gardner HA, Violette SM

Identification and molecular characterization of multiple phenotypes in integrin knockout mice.

Methods in enzymology

Chen C, Sheppard D

Pulmonary emphysema: when more is less.

Physiology (Bethesda, Md.)

Morris DG, Sheppard D

The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling.

Immunity

Chen C, Huang X, Atakilit A, Zhu QS, Corey SJ, Sheppard D

Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.

American journal of respiratory cell and molecular biology

Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF

Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Rao H, Lu G, Kajiya H, Garcia-Palacios V, Kurihara N, Anderson J, Patrene K, Sheppard D, Blair HC, Windle JJ, Choi SJ, Roodman GD

ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.

Molecular and cellular biology

Chen C, Huang X, Sheppard D

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.

Proceedings of the National Academy of Sciences of the United States of America

Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA

Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis.

Proceedings of the American Thoracic Society

Sheppard D

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

The Journal of clinical investigation

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D

Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.

American journal of respiratory cell and molecular biology

Neurohr C, Nishimura SL, Sheppard D

Population stratification confounds genetic association studies among Latinos.

Human genetics

Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard D, Shriver MD, Rodriguez-Cintron W, Risch N, Ziv E, Burchard EG, Genetics of Asthma in Latino Americans GALA Study

Mfge8 is critical for mammary gland remodeling during involution.

Molecular biology of the cell

Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D

Integrin-mediated activation of latent transforming growth factor beta.

Cancer metastasis reviews

Sheppard D

Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics.

Genetic epidemiology

Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard D, Rodriguez-Cintron W, Risch NJ, Burchard EG, Ziv E

ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7.

The Biochemical journal

Bridges LC, Sheppard D, Bowditch RD

Characterization of integrin beta6 and thrombospondin-1 double-null mice.

Journal of cellular and molecular medicine

Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J

Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.

The Journal of biological chemistry

Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF

Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma.

The Journal of clinical investigation

Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.

The Journal of experimental medicine

Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC

The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.

The Journal of biological chemistry

Vlahakis NE, Young BA, Atakilit A, Sheppard D

Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.

American journal of respiratory and critical care medicine

Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard EG

Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL

Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension?

American journal of respiratory and critical care medicine

Sheppard D

Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration.

The Journal of cell biology

Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D

Roles of alphav integrins in vascular biology and pulmonary pathology.

Current opinion in cell biology

Sheppard D

Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.

Journal of virology

Williams CH, Kajander T, Hyypiä T, Jackson T, Sheppard D, Stanway G

Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.

Biochemistry

Bazan-Socha S, Kisiel DG, Young B, Theakston RD, Calvete JJ, Sheppard D, Marcinkiewicz C

Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes.

The Journal of biological chemistry

Weinreb PH, Simon KJ, Rayhorn P, Yang WJ, Leone DR, Dolinski BM, Pearse BR, Yokota Y, Kawakatsu H, Atakilit A, Sheppard D, Violette SM

Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma.

American journal of respiratory and critical care medicine

Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK, Genetics of Asthma in Latino Americans (GALA) Study

Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.

Experimental cell research

Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM

Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice.

The American journal of pathology

Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB

Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.

American journal of respiratory cell and molecular biology

Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM

ADAM33 is not associated with asthma in Puerto Rican or Mexican populations.

American journal of respiratory and critical care medicine

Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, González Burchard E

Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.

The Journal of biological chemistry

Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF

Functions of pulmonary epithelial integrins: from development to disease.

Physiological reviews

Sheppard D

The importance of race and ethnic background in biomedical research and clinical practice.

The New England journal of medicine

Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.

Nature

Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D

Endothelial integrins and angiogenesis: not so simple anymore.

The Journal of clinical investigation

Sheppard D

Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1.

The American journal of pathology

Knight PA, Wright SH, Brown JK, Huang X, Sheppard D, Miller HR

Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.

American journal of respiratory and critical care medicine

Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

Nature medicine

Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.

Proceedings of the National Academy of Sciences of the United States of America

Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.

The Journal of cell biology

Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL

Killed by leukocytes that don't know when to leave.

Nature immunology

Sheppard D

Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.

The Journal of cell biology

Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA

Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.

The Journal of biological chemistry

Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y

Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema.

Chest

Sheppard D

Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans.

Chest

Kaminski N, Zuo F, Cojocaro G, Yakhini Z, Ben-Dor A, Morris D, Sheppard D, Pardo A, Selman M, Heller RA

The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing.

The Journal of biological chemistry

Liao YF, Gotwals PJ, Koteliansky VE, Sheppard D, Van De Water L

Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus.

Journal of virology

Jackson T, Mould AP, Sheppard D, King AM

Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins.

Nature medicine

Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM

Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC

Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

American journal of respiratory cell and molecular biology

Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D

The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner.

Molecular biology of the cell

Young BA, Taooka Y, Liu S, Askins KJ, Yokosaki Y, Thomas SM, Sheppard D

Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

The Journal of investigative dermatology

Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF

Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis.

Chest

Sheppard D

Pulmonary fibrosis: a cellular overreaction or a failure of communication?

The Journal of clinical investigation

Sheppard D

TGF-beta is a critical mediator of acute lung injury.

The Journal of clinical investigation

Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D

Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus.

Journal of virology

Miller LC, Blakemore W, Sheppard D, Atakilit A, King AM, Jackson T

Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Miller LA, Barnett NL, Sheppard D, Hyde DM

RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction.

The Journal of biological chemistry

Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y

Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.

The Journal of biological chemistry

Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D

A primary culture model of differentiated murine tracheal epithelium.

American journal of physiology. Lung cellular and molecular physiology

Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR

Functional genomics and expression profiling: be there or be square.

American journal of respiratory cell and molecular biology

Albelda SM, Sheppard D

Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1.

The Journal of biological chemistry

Takahashi H, Isobe T, Horibe S, Takagi J, Yokosaki Y, Sheppard D, Saito Y

Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.

Molecular and cellular biology

Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D

In vivo functions of integrins: lessons from null mutations in mice.

Matrix biology : journal of the International Society for Matrix Biology

Sheppard D

The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus.

Journal of virology

Jackson T, Sheppard D, Denyer M, Blakemore W, King AM

Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair.

Trends in cardiovascular medicine

Yokasaki Y, Sheppard D

Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line.

The Journal of physiology

Lansdell KA, Cai Z, Kidd JF, Sheppard DN

Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.

Proceedings of the National Academy of Sciences of the United States of America

Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppard D, Heller RA

Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice.

Molecular and cellular biology

Huang X, Griffiths M, Wu J, Farese RV, Sheppard D

The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin.

The Journal of biological chemistry

Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D

Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA.

Investigative ophthalmology & visual science

Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ

Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration.

Journal of cell science

Milner R, Huang X, Wu J, Nishimura S, Pytela R, Sheppard D, ffrench-Constant C

Airway remodeling and repair.

American journal of respiratory and critical care medicine

Busse W, Elias J, Sheppard D, Banks-Schlegel S

Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents.

British journal of pharmacology

Cai Z, Lansdell KA, Sheppard DN

Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium.

The European respiratory journal

Roger P, Puchelle E, Bajolet-Laudinat O, Tournier JM, Debordeaux C, Plotkowski MC, Cohen JH, Sheppard D, de Bentzmann S

The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1.

The Journal of cell biology

Taooka Y, Chen J, Yednock T, Sheppard D

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

Cell

Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D

Requirement for IL-13 independently of IL-4 in experimental asthma.

Science (New York, N.Y.)

Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB

Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation.

Journal of cellular biochemistry

Desloges N, Basora N, Perreault N, Bouatrouss Y, Sheppard D, Beaulieu JF

Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice.

American journal of respiratory cell and molecular biology

Huang X, Wu J, Zhu W, Pytela R, Sheppard D

Airway epithelial integrins: why so many?

American journal of respiratory cell and molecular biology

Sheppard D

The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin.

Journal of cell science

Huang X, Wu J, Spong S, Sheppard D

A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins.

FEBS letters

Schneider H, Harbottle RP, Yokosaki Y, Kunde J, Sheppard D, Coutelle C

Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C.

The Journal of biological chemistry

Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D

Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.

Molecular medicine (Cambridge, Mass.)

Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM

Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells.

The Journal of physiology

Lansdell KA, Delaney SJ, Lunn DP, Thomson SA, Sheppard DN, Wainwright BJ

Expression of the alpha9beta1 integrin in human colonic epithelial cells: resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines.

International journal of cancer

Basora N, Desloges N, Chang Q, Bouatrouss Y, Gosselin J, Poisson J, Sheppard D, Beaulieu JF

Distinct structural requirements for interaction of the integrins alpha 5 beta 1, alpha v beta 5, and alpha v beta 6 with the central cell binding domain in fibronectin.

Cell adhesion and communication

Chen J, Maeda T, Sekiguchi K, Sheppard D

Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium.

The American journal of physiology

Hérard AL, Pierrot D, Hinnrasky J, Kaplan H, Sheppard D, Puchelle E, Zahm JM

Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture.

The Journal of biological chemistry

Dixit RB, Chen A, Chen J, Sheppard D

Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.

The Journal of biological chemistry

Yokosaki Y, Monis H, Chen J, Sheppard D

Epithelial integrins.

BioEssays : news and reviews in molecular, cellular and developmental biology

Sheppard D

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.

The Journal of cell biology

Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D

Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.

British journal of cancer

Agrez MV, Bates RC, Mitchell D, Wilson N, Ferguson N, Anseline P, Sheppard D

Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells.

Experimental cell research

Kumar NM, Sigurdson SL, Sheppard D, Lwebuga-Mukasa JS

Expression of the integrin subunit alpha 9 in the murine embryo.

Developmental dynamics : an official publication of the American Association of Anatomists

Wang A, Patrone L, McDonald JA, Sheppard D

Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5.

The Journal of clinical investigation

Boylan AM, Sanan DA, Sheppard D, Broaddus VC

The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.

The Journal of biological chemistry

Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R

A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.

American journal of respiratory cell and molecular biology

Huang XZ, Chen A, Agrez M, Sheppard D

Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.

American journal of respiratory cell and molecular biology

Weinacker A, Ferrando R, Elliott M, Hogg J, Balmes J, Sheppard D

Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Stepp MA, Zhu L, Sheppard D, Cranfill RL

Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.

Journal of cell science

Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R

The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.

The Journal of biological chemistry

Yokosaki Y, Palmer EL, Prieto AL, Crossin KL, Bourdon MA, Pytela R, Sheppard D

The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain.

The Journal of cell biology

Agrez M, Chen A, Cone RI, Pytela R, Sheppard D

Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain.

The Journal of biological chemistry

Lukashev ME, Sheppard D, Pytela R

Dominant negative mutants: tools for the study of protein function in vitro and in vivo.

American journal of respiratory cell and molecular biology

Sheppard D

Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts.

Cell adhesion and communication

Cone RI, Weinacker A, Chen A, Sheppard D

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

The Journal of biological chemistry

Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D

Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.

Methods in enzymology

Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D

Identification and characterization of novel airway epithelial integrins.

The American review of respiratory disease

Sheppard D

Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle.

The Journal of cell biology

Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D

Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Breuss JM, Gillett N, Lu L, Sheppard D, Pytela R

Occupational asthma in a pesticides manufacturing worker.

Chest

Royce S, Wald P, Sheppard D, Balmes J

Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells.

The Journal of biological chemistry

Sheppard D, Cohen DS, Wang A, Busk M

Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.

American journal of respiratory cell and molecular biology

Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

The Journal of biological chemistry

Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R

A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs.

The American review of respiratory disease

Sheppard D, Scypinski L

Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction.

Chest

Turner JR, Corkery KJ, Eckman D, Gelb AM, Lipavsky A, Sheppard D

Interaction of cromolyn and a muscarinic antagonist in inhibiting bronchial reactivity to sulfur dioxide and to eucapnic hyperpnea alone.

The American review of respiratory disease

Myers DJ, Bigby BG, Calvayrac P, Sheppard D, Boushey HA

Granulocyte-mediated airway edema in guinea pigs.

Journal of applied physiology (Bethesda, Md. : 1985)

Sheppard D, Scypinski L, Horn J, Gordon T, Thompson JE

The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.

The American review of respiratory disease

Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley WK, Hopewell PC

Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma.

The American review of respiratory disease

Siegel D, Sheppard D, Gelb A, Weinberg PF

Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone.

The American review of respiratory disease

Eschenbacher WL, Boushey HA, Sheppard D

Purification of uroporphyrinogen decarboxylase from human erythrocytes. Immunochemical evidence for a single protein with decarboxylase activity in human erythrocytes and liver.

The Biochemical journal

Elder GH, Tovey JA, Sheppard DM

Publications