
Professor
Orofacial Sciences
+1 415 502-2096
Licia Selleri, MD, PhD studies the genetic and regulatory control of cranial and appendicular morphogenesis in embryonic development, evolution and disease using different model and non-model organisms.
Publications
A long-ignored skeletal tissue filled with oil.
Science (New York, N.Y.)
PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.
bioRxiv : the preprint server for biology
Conserved enhancers control notochord expression of vertebrate Brachyury.
Nature communications
ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.
Developmental biology
A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.
Nature communications
Shaping faces: genetic and epigenetic control of craniofacial morphogenesis.
Nature reviews. Genetics
Conserved enhancer logic controls the notochord expression of vertebrate Brachyury.
bioRxiv : the preprint server for biology
Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.
bioRxiv : the preprint server for biology
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
The EMBO journal
Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder.
Cell stem cell
FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research.
Development (Cambridge, England)
A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.
Developmental cell
Ubiquitous overexpression of CXCL12 confers radiation protection and enhances mobilization of hematopoietic stem and progenitor cells.
Stem cells (Dayton, Ohio)
Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease.
Human molecular genetics
Corrigendum: 'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.
Genes & development
'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.
Genes & development
Genetics of scapula and pelvis development: An evolutionary perspective.
Current topics in developmental biology
Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons.
Proceedings of the National Academy of Sciences of the United States of America
Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface.
Journal of anatomy
Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion.
Development (Cambridge, England)
PBX transcription factors drive pulmonary vascular adaptation to birth.
The Journal of clinical investigation
De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.
Human molecular genetics
Toward Microsurgical Correction of Cleft Lip Ex Utero through Restoration of Craniofacial Developmental Programs.
Plastic and reconstructive surgery
A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?
PLoS genetics
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.
The EMBO journal
The FaceBase Consortium: a comprehensive resource for craniofacial researchers.
Development (Cambridge, England)
Pbx1 is required for adult subventricular zone neurogenesis.
Development (Cambridge, England)
Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.
Journal of anatomy
Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.
Development (Cambridge, England)
An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.
Nature genetics
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.
Science (New York, N.Y.)
ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling.
Cell reports
Pbx1 activates Fgf10 in the mesenchyme of developing lungs.
Genesis (New York, N.Y. : 2000)
ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.
Molecular and cellular biology
Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia.
Science (New York, N.Y.)
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
The EMBO journal
Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Developmental cell
A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
Developmental cell
Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex.
Cells, tissues, organs
Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.
Developmental cell
Control of pelvic girdle development by genes of the Pbx family and Emx2.
Developmental dynamics : an official publication of the American Association of Anatomists
Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.
Developmental dynamics : an official publication of the American Association of Anatomists
Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.
Development (Cambridge, England)
Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner.
The International journal of developmental biology
Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.
Genesis (New York, N.Y. : 2000)
Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.
Circulation research
Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.
Developmental biology
Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.
Molecular and cellular biology
Development and function of the mammalian spleen.
BioEssays : news and reviews in molecular, cellular and developmental biology
Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.
Molecular and cellular biology
Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.
Developmental biology
Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.
Development (Cambridge, England)
Hox cofactors in vertebrate development.
Developmental biology
Spatio-temporal expression of Pbx3 during mouse organogenesis.
Gene expression patterns : GEP
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.
Development (Cambridge, England)
Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs.
Developmental biology
Pbx3 deficiency results in central hypoventilation.
The American journal of pathology
The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.
Molecular and cellular biology
Pbx1 is essential for adrenal development and urogenital differentiation.
Genesis (New York, N.Y. : 2000)
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
Nature genetics
Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.
Development (Cambridge, England)
Expression of Pbx1b during mammalian organogenesis.
Mechanisms of development
Molecular cytogenetics localizes two new breakpoints on 11q23.3 and 21q11.2 in myelodysplastic syndrome with t(11;21) translocation.
Genes, chromosomes & cancer
Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus.
The Journal of biological chemistry
De novo 46,XX, dir dup (11)(q133.3-->q14.2) in a patient with mental retardation, congenital cardiopathy and thrombopenia.
Clinical genetics
A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues.
Human molecular genetics
Spontaneous loss of Ph chromosome with maintenance of clonal hemopoiesis in an untreated patient with myeloproliferative disease and a long survival.
Genes, chromosomes & cancer
Cloning of the entire FLI1 gene, disrupted by the Ewing's sarcoma translocation breakpoint on 11q24, in a yeast artificial chromosome.
Cytogenetics and cell genetics
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.
Nature genetics
A novel zinc finger gene on human chromosome 1qter that is alternatively spliced in human tissues and cell lines.
American journal of human genetics
Localization of the human oncostatin M gene (OSM) to chromosome 22q12, distal to the Ewing's sarcoma breakpoint.
Cytogenetics and cell genetics
Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22.
Cytogenetics and cell genetics
Interphase cytogenetics for the detection of the t(11;22)(q24;q12) in small round cell tumors.
The Journal of clinical investigation
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.
Nature genetics
Chromosomal in situ hybridization using yeast artificial chromosomes.
Genetic analysis, techniques and applications
Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization.
Proceedings of the National Academy of Sciences of the United States of America
Sinus histiocytosis with massive lymphadenopathy: immunological, cytogenetic and molecular studies.
Blut
[Mitochondrial DNA deletion in a case of progressive ophthalmoplegia].
Medicina (Florence, Italy)
Chronic myelogenous leukemia with typical clinical and morphological features can be Philadelphia chromosome negative and "bcr negative".
Hematologic pathology
Extramedullary pleural blast crisis in chronic myelogenous leukemia: cytogenetic and molecular study.
Acta haematologica
[Identification of human herpesvirus HHV-6 sequence in a case of Hodgkin's disease by polymerase chain reaction].
Medicina (Florence, Italy)
Serum antibodies to thymus epithelial cells in non-A, non-B and cryptogenic chronic liver disease.
Liver
Cytogenetic and molecular studies in primary myelofibrosis.
Cancer genetics and cytogenetics
Isodicentric X chromosome in myeloproliferative disorders.
Acta haematologica
[Polymerase chain reaction for the diagnostic identification of HIV infection].
Medicina (Florence, Italy)
[Possible correlations between proliferation and differentiation of blast cells in acute promyelocytic leukemia: a molecular study].
Medicina (Florence, Italy)
bcr-abl oncogene activation in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Leukemia
Prognostic significance of "short-term" effects of chemotherapy on MYC and histone H3 mRNA levels in acute leukemia patients.
Proceedings of the National Academy of Sciences of the United States of America
Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa.
Cancer research
Establishment and characterization of a human IgA-kappa-secreting plasma cell line (MT3).
International journal of cancer
Immunoglobulin and T-cell receptor beta chain gene rearrangements as lineage markers in human leukemias: a study of 78 cases.
Haematologica
Promyelocytic crisis of chronic myeloid leukaemia.
British journal of haematology
Molecular study of the Philadelphia translocation in chronic myelogenous leukemia in different stages of disease.
Haematologica
Simultaneously increased expression of the c-myc and mu chain genes in the acute blastic transformation of a chronic lymphocytic leukaemia.
British journal of haematology
Clinical subsets of scleroderma: relevance of fluorescent and precipitating antinuclear antibodies.
Clinical and experimental rheumatology
Nuclear protrusions and marker chromosomes in lymphocytes of two patients with cutaneous T-cell lymphoma.
Acta haematologica
Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells.
Cancer research
Cellular levels of mRNA from c-myc, c-myb and c-fes onc-genes in normal myeloid and erythroid precursors of human bone marrow: an in situ hybridization study.
British journal of haematology
Differential patterns of expression of cell cycle-related genes in blast cells of acute myeloid leukemia.
Leukemia research
Activation of c-myb expression by phytohemagglutinin stimulation in normal human T lymphocytes.
Molecular and cellular biology
Expression of human c-fes onc-gene occurs at detectable levels in myeloid but not in lymphoid cell populations.
British journal of haematology
Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage.
Leukemia research
Low-dose intravenous pepsin-treated gammaglobulin for idiopathic thrombocytopenic purpura in adults.
British journal of haematology