James Rubenstein, MD, PhD

Professor
[email protected]
+1 415 502-4430

James Rubenstein, MD, PhD is working to define the molecular features of non-Hodgkin's lymphoma of the central nervous system using microarray technology.

Publications: 

Small molecule protein assembly modulators with pan-cancer therapeutic efficacy.

Open biology

Lingappa AF, Akintunde O, Samueli E, Ewald C, Michon M, Ziari N, Lu M, Yu SF, Froehlich M, Le PU, Fernandez Y, Mallesh S, Lin J, Kitaygorodskyy A, Solas D, Reed JC, Lingappa JR, Müller-Schiffmann A, Korth C, Prasad D, Nalca A, Aston E, Fabbri B, Anand SK, Campi TW, Petrouski E, Dey D, Andrews DW, Rubenstein JL, Lingappa VR

Clinicopathologic features of primary central nervous system anaplastic large cell lymphoma: a multicenter study identifies age and ALK status as prognostic factors.

Journal of hematopathology

Morrow WP, Milligan NS, Ohgami RS, Young KH, Wang B, Vega F, Marques-Piubelli ML, Feldman AL, Slack GW, Savage KJ, Zhao X, Rubenstein JL, Hsi ED

Identification of Genomic Biomarkers of Disease Progression and Survival in Primary CNS Lymphoma.

Blood advances

Geng H, Mo SS, Chen L, Ballapuram A, Tsang M, Lu M, Rauschecker AM, Wen KW, Devine WP, Solomon DA, Rubenstein JL

BTK Degradation As a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Patient-Derived, Rodent Models.

Blood

Jun Ma, Michael P Randall, Ming Lu, Lingjing Chen, Huimin Geng, Aishwarya Kumar, Saloni Malla, Mark Noviski, Ryan Rountree, James L. Rubenstein

Toll-like Receptor 7/8 Pathway Is a Therapeutic Target in Primary CNS Lymphoma.

Blood

Michael P Randall, Huimin Geng, Lingjing Chen, Aishwarya Ballapuram, Chitoh Yung, Ming Lu, Gregory Chin, Michael Mish, Jamie Bates, James L. Rubenstein

Trial in Progress - Alliance A051901 - Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab (Nivo-MR2) Induction Followed By Lenalidomide and Nivolumab Maintenance in Primary Central Nervous System Lymphoma (PCNSL).

Blood

Alvaro J Alencar, Olivia Bobek, Neha Mehta-Shah, Narendranath Epperla, Christine Lu-Emerson, Sarah C. Rutherford, Adam J. Olszewski, Thomas Ollila, Samuel Singer, Travis Dockter, Susan M. Geyer, Lori Rosenstein, Macarena De La Fuente, Eric D. Hsi, Shira N. Dinner, James L. Rubenstein, Nancy L. Bartlett, John P. Leonard

Myeloablative Vs. Non-Myeloablative Consolidation for Primary Central Nervous System Lymphoma: Results of Alliance 51101.

Blood advances

Batchelor TT, Giri S, Ruppert AS, Geyer S, Smith SE, Mohile N, Swinnen LJ, Friedberg JW, Kahl BS, Bartlett NL, Hsi ED, Cheson BD, Wagner-Johnston ND, Nayak L, Leonard JP, Rubenstein JL

Utility of PD-1, PD-L1, and IDO-1 Stains in Ocular Extranodal Marginal Zone Lymphoma (MZL) and Diffuse Large B-cell Lymphoma (DLBCL).

Applied immunohistochemistry & molecular morphology : AIMM

Craig A, Güney E, Pekmezci M, Bloomer M, Laszik Z, Ohgami RS, Toland A, Vogel H, Forns T, Wang E, Rubenstein J, Wen KW

Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: a RANO review.

Neuro-oncology

Nayak L, Bettegowda C, Scherer F, Galldiks N, Ahluwalia M, Baraniskin A, von Baumgarten L, Bromberg JEC, Ferreri AJM, Grommes C, Hoang-Xuan K, Kühn J, Rubenstein JL, Rudà R, Weller M, Chang SM, van den Bent MJ, Wen PY, Soffietti R

Trial in Progress: A Phase I/II Study of Tafasitamab Plus Lenalidomide in Patients with Relapsed CNS Lymphoma.

Blood

Michael P Randall, Andreas Rauschecker, Liam Gima-Lange, Jenai Wilmoth, Lingjing Chen, Ming Lu, Huimin Geng, Haifaa Abdulhaq, James L. Rubenstein

Molecular profiling identifies at least 3 distinct types of posttransplant lymphoproliferative disorder involving the CNS.

Blood advances

Guney E, Lucas CG, Singh K, Pekmezci M, Fernandez-Pol S, Mirchia K, Toland A, Vogel H, Bannykh S, Schafernak KT, Alexandrescu S, Mobley BC, Powell S, Davidson CJ, Neltner J, Boué DR, Hattab E, Ferris SP, Ohgami RS, Rubenstein JL, Bollen AW, Tihan T, Perry A, Solomon DA, Wen KW

BTK Degradation as a Novel Therapeutic Strategy in Relapsed CNS Lymphoma: Proof of Concept Studies in Intracranial Preclinical including Patient-Derived Models.

Hematological oncology

J. Ma, M. Lu, L. Chen, H. Geng, A. Kumar, M. Noviski, R. Rountree, C. Guiducci, J. Rubenstein

IDENTIFICATION OF GENOMIC BIOMARKERS OF DISEASE PROGRESSION AND SURVIVAL IN NEWLY-DIAGNOSED PRIMARY CNS LYMPHOMA.

Hematological oncology

S. Mo, H. Geng, A. Ballapuram, L. Chen, M. Lu, W. P. Devine, K. W. Wen, D. Solomon, J. Rubenstein

Older patients with primary central nervous system lymphoma: Survival and prognostication across 20 U.S. cancer centers.

American journal of hematology

David KA, Sundaram S, Kim SH, Vaca R, Lin Y, Singer S, Malecek MK, Carter J, Zayac A, Kim MS, Reddy N, Ney D, Habib A, Strouse C, Graber J, Bachanova V, Salman S, Vendiola JA, Hossain N, Tsang M, Major A, Bond DA, Agrawal P, Mier-Hicks A, Torka P, Rajakumar P, Venugopal P, Berg S, Glantz M, Goldlust SA, Folstad M, Kumar P, Ollila TA, Cai J, Spurgeon S, Sieg A, Cleveland J, Chang J, Epperla N, Karmali R, Naik S, Martin P, Smith SM, Rubenstein J, Kahl B, Evens AM

EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort.

Leukemia & lymphoma

Agrawal P, David KA, Chen Z, Sundaram S, Kim SH, Vaca R, Lin Y, Singer S, Malecek MK, Carter J, Zayac A, Kim MS, Reddy N, Ney D, Habib A, Strouse C, Graber J, Bachanova V, Salman S, Vendiola JA, Hossain N, Tsang M, Major A, Gandhi MK, Keane C, Bond DA, Folstad M, Chang J, Mier-Hicks A, Torka P, Rajakumar P, Venugopal P, Berg S, Glantz M, Goldlust SA, Matnani R, Kumar P, Ollila TA, Cai J, Spurgeon SE, Sieg AG, Cleveland J, Epperla N, Karmali R, Naik S, Smith SM, Rubenstein JL, Kahl BS, Chadburn A, Evens AM, Martin P

Stereotactic Radiosurgery for Primary Central Nervous System Lymphoma.

Cureus

Wu SY, Braunstein SE, Rubenstein JL, Sneed PK

Tafasitamab at the blood-brain barrier.

British journal of haematology

Rauschecker AM, Mo SS, Randall M, Shen-Sampas J, Rubenstein JL

Primary CNS lymphoma: update on molecular pathogenesis and therapy.

Leukemia & lymphoma

Mo SS, Cleveland J, Rubenstein JL

Primary CNS Lymphoma: Progress With Dose-Intensive Consolidation.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Rubenstein JL

A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome.

Blood advances

Güney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak K, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen A, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW

Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment.

Blood

Hua-Xin Gao, Eleanor Fraser, Mario Merlini, Huimin Geng, Lingjing Chen, Ming Lu, Yasmin Moshfegh, Joseph Cleveland, Jae Ryu, Jigyasa Sharma, David A. Solomon, Katerina Akassoglou, Clifford Lowell, James L. Rubenstein

Tumor metabolism and neurocognition in CNS lymphoma.

Neuro-oncology

Geng H, Tsang M, Subbaraj L, Cleveland J, Chen L, Lu M, Sharma J, Vigneron DB, Kurhanewicz J, LaFontaine M, Luks T, Barshop BA, Gangoiti J, Villanueva-Meyer JE, Rubenstein JL

A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America

Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA

Consensus recommendations for MRI and PET imaging of primary central nervous system lymphoma: guideline statement from the International Primary CNS Lymphoma Collaborative Group (IPCG).

Neuro-oncology

Barajas RF, Politi LS, Anzalone N, Schöder H, Fox CP, Boxerman JL, Kaufmann TJ, Quarles CC, Ellingson BM, Auer D, Andronesi OC, Ferreri AJM, Mrugala MM, Grommes C, Neuwelt EA, Ambady P, Rubenstein JL, Illerhaus G, Nagane M, Batchelor TT, Hu LS

Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of CALGB 51101 (Alliance).

Journal of Clinical Oncology

Tracy Batchelor, Sharmila Giri, Amy S. Ruppert, Nancy L. Bartlett, Eric D. Hsi, Bruce D. Cheson, Lakshmi Nayak, John Paul Leonard, James L. Rubenstein

Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma.

The American journal of pathology

Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK

Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide.

Blood

Mazie Tsang, Joseph Cleveland, Miguel Carlos Cerejo, Huimin Geng, James L. Rubenstein

On point in primary CNS lymphoma.

Hematological oncology

Tsang M, Cleveland J, Rubenstein JL

Cutaneous T-Cell Lymphoma PDX Drug Screening Platform Identifies Cooperation between Inhibitions of PI3Kα/δ and HDAC.

The Journal of investigative dermatology

Wu CH, Yang CY, Wang L, Gao HX, Rakhshandehroo T, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ

Myeloablative versus non-myeloablative consolidative chemotherapy for newly diagnosed primary central nervous system lymphoma: Results of induction therapy in Alliance 51101.

Journal of Clinical Oncology

Tracy Batchelor, Sharmila Giri, Amy S. Ruppert, Nancy L. Bartlett, Eric D. Hsi, Bruce D. Cheson, Lakshmi Nayak, John Paul Leonard, James L. Rubenstein

THERAPEUTIC VITRECTOMY AS AN ADJUNCT TREATMENT TO SYSTEMIC CHEMOTHERAPY FOR INTRAOCULAR LYMPHOMA.

Retinal cases & brief reports

Bever GJ, Kim DJ, Afshar AR, Rubenstein JL, Damato BE

Development of a Pathway-Directed Drug Screen Platform for Cutaneous T Cell Lymphoma Using Patient-Derived Xenograft Models.

Blood

CHI-HENG WU, Chen-Yen Yang, Linlin Wang, Hua-Xin Gao, Rakhshandehroo Taha, Shervin Afghani, Laura Pincus, Ronald Balassanian, James Rubenstein, Ryan Gill, Sourav Bandyopadhyay, Frank McCormick, Mark Moasser, Weiyun Z. Ai

Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies.

Blood

David A. Solomon, Huimin Geng, Raymond A. Sobel, Lakshmi Subbaraj, Mazie Tsang, James L. Rubenstein

Maintenance lenalidomide in primary CNS lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology

Rubenstein JL, Geng H, Vu K, Mannis G, Formaker P, Hwang J, Munster PN, Damato B

An audit of retinal lymphoma treatment at the University of California San Francisco.

Eye (London, England)

Damato B, Bever GJ, Kim DJ, Afshar AR, Rubenstein JL

Evolving Treatments for Primary Central Nervous System Lymphoma.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

Ferreri AJM, Holdhoff M, Nayak L, Rubenstein JL

Comprehensive approach to diagnosis and treatment of newly diagnosed primary CNS lymphoma.

Neuro-oncology

Grommes C, Rubenstein JL, DeAngelis LM, Ferreri AJM, Batchelor TT

Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma.

Blood

Huimin Geng, Brice Tiret, Hua-Xin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Ilwoo Park, Gerd Melkus, Adam Elkhaled, John Kurhanewicz, Lisa Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, Rana Anjum, Andrew Bloecher, Myriam Chaumeil, James Rubenstein

Low-Dose Lenalidomide Maintenance after Induction Therapy in Older Patients with Primary CNS Lymphoma.

Blood

Khoan Vu, James Rubenstein, Gabriel N. Mannis, Jimmy Hwang, Huimin Geng

RTHP-31. STEREOTACTIC RADIOSURGERY FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA.

Neuro-oncology

Susan Wu, Steve Braunstein, James Rubenstein, Penny Sneed

Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.

Blood advances

Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, Damato B

Abstract 4975: Tumor metabolism and cognitive dysfunction in CNS lymphoma.

Cancer research

Lakshmi Subbaraj, Huimin Geng, Jigyasa Sharma, Marisa LaFontaine, James L. Rubenstein

Insights from a Case of Vitreoretinal Lymphoma.

Ocular oncology and pathology

Damato BE, Bever GJ, Afshar AR, Rubenstein JL

Biology of CNS lymphoma and the potential of novel agents.

Hematology. American Society of Hematology. Education Program

Rubenstein JL

EXTH-71. HYPERPOLARIZED [1-13C] PYRUVATE AS A BIOMARKER FOR TREATMENT MONITORING IN LYMPHOMA MURINE MODELS.

Neuro-oncology

Brice Tiret, Adam Autry, Ilwoo Park, Ming Lu, Rana Anjum, Liza Drew, Sebastien Degorce, Michele Mayo, Keith Dillman, James Rubenstein, Myriam M Chaumeil

CHECKMATE 647: A PHASE 2, OPEN-LABEL STUDY OF NIVOLUMAB IN RELAPSED/REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA OR RELAPSED/REFRACTORY PRIMARY TESTICULAR LYMPHOMA.

Hematological oncology

L. Nayak, F.M. Iwamoto, A.J. Ferreri, A. Santoro, S. Singer, C. Batlevi, T. Batchelor, J. Rubenstein, P. Johnston, R. Ramchandren, C. Soussain, J. Drappatz, K. Becker, M. Witzens-Harig, G. Illerhaus, A. Herrera, A. Masood, M. Shipp

Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma.

Blood

Huimin Geng, Huaxin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Rana Anjum, Lisa Drew, Sebastien Degorce, Keith Dillman, Michele Mayo, Shawn Anderson, Colin Collins, Clifford A. Lowell, James L. Rubenstein

The Challenge of Primary Central Nervous System Lymphoma.

Hematology/oncology clinics of North America

Carnevale J, Rubenstein JL

ATIM-27. PHASE I INVESTIGATION OF LENALIDOMIDE PLUS RITUXIMAB AND OUTCOMES OF LENALIDOMIDE MAINTENANCE IN RECURRENT CNS LYMPHOMA.

Neuro-oncology

James Rubenstein, Eleanor Fraser, Paul Formaker, James Chi-Chiang Lee, Nianhang Chen, Mallory Kock, Wesley Cheung, Phoebe Killea, Kee-Hyun Choi, Xiaomin Wang, Pamela Munster, Bertil Damato

Long-term survival in AIDS-related primary central nervous system lymphoma.

Neuro-oncology

Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL

Abstract A06: Development of a drug discovery platform using clinically relevant patient-derived xenograft models for cutaneous T cell lymphomas.

Clinical Cancer Research

Wei Ai, Yen-Chen Yang Yang, Shervin Afghani, Huaxin Gao, Laura Pincus Pincus, Linlin Wang Wang, Taha Rakhshandhroo, Ronald Balassanian, James Rubenstein, Ryan Gill, Frank McCormick

Phase I investigation of lenalidomide plus rituximab and outcomes of lenalidomide maintenance in recurrent CNS lymphoma.

Journal of Clinical Oncology

James L. Rubenstein, Eleanor Fraser, Paul Formaker, James Chi-Chiang Lee, Nianhang Chen, Mallory Kock, Wesley Cheung, Xiaomin Wang, Pamela N. Munster, Bertil Damato

The role of whole brain radiation in primary CNS lymphoma.

Blood

Kasenda B, Loeffler J, Illerhaus G, Ferreri AJ, Rubenstein J, Batchelor TT

Therapy for Secondary CNS Involvement in Malignant Lymphomas: No Standard Yet!

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Korfel A, Chamberlain M, Neuwelt E, Thiel E, Doolittle N, Schlegel U, Dreyling M, Rubenstein J, Fischer L, Björkholm M, Martus P, Weller M, Glantz M

Expression of B and T Lymphocyte Attenuator (BTLA) Correlates with CNS Metastasis and Adverse Prognosis in Activated B-Cell Lymphoma and Acute Lymphoblastic Leukemia.

Blood

Huimin Geng, Zhengshan Chen, Shawn Anderson, Eleanor Fraser, Ming Lu, Chen Lingjing, Colin Collins, Muschen Markus, James L. Rubenstein

Performance of Apparent Diffusion Coefficient Values and Conventional MRI Features in Differentiating Tumefactive Demyelinating Lesions From Primary Brain Neoplasms.

AJR. American journal of roentgenology

Mabray MC, Cohen BA, Villanueva-Meyer JE, Valles FE, Barajas RF, Rubenstein JL, Cha S

Prolonged Complete Response in a Pediatric Patient With Primary Peripheral T-Cell Lymphoma of the Central Nervous System.

Pediatric hematology and oncology

Shalabi H, Angiolillo A, Vezina G, Rubenstein JL, Pittaluga S, Raffeld M, Marcus L

New approaches in primary central nervous system lymphoma.

Chinese clinical oncology

Fraser E, Gruenberg K, Rubenstein JL

77-year-old woman with a dural-based mass. Marginal zone B-cell lymphoma (MZBCL).

Brain pathology (Zurich, Switzerland)

Okimoto RA, Perry A, Rubenstein JL

Interim Results of a Phase I Study of Lenalidomide (CC-5013) Plus Intraventricular/Intravenous Rituximab for Recurrent/Refractory CNS and Intraocular Lymphoma.

Blood

James L. Rubenstein, Paul Formaker, Xiaomin Wang, Nianhang Chen, Michael Seider, Pamela Munster, Bertil Damato

Progress in central nervous system lymphomas.

British journal of haematology

Wang CC, Carnevale J, Rubenstein JL

Reply to M.C. Chamberlain.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Rubenstein JL, Cheson BD, Jung SH, Kaplan LD

50 Brain Metastases and Neoplastic Meningitis.

Penny K. Sneed, Norbert Kased, James L. Rubenstein

CNS Lymphoma.

Rare Lymphomas

Agnieszka Korfel, James Rubenstein, German Ott, Eric D. Hsi

Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy.

Blood

Hua-Xin Gao, Shawn Anderson, Cigall Kadoch, Mekhala Maiti, Lingjing Chen, Dong-Han Yao, Gerd Melkus, Maria Wang, Yan Ren, Michael Breider, Carla Heise, Clifford A. Lowell, Colin Collins, James L. Rubenstein

Obesity and Hepatitis B Infection and Risk Of Primary CNS Lymphoma.

Blood

Chia-Ching J. Wang, Paige M Bracci, James L. Rubenstein

Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL

How I treat CNS lymphomas.

Blood

Rubenstein JL, Gupta NK, Mannis GN, Lamarre AK, Treseler P

The roles of tumor associated macrophages and interferon gamma in immune surveillance in CNS lymphoma (P2211).

The Journal of Immunology

Hua-Xin Gao, Valerie Wong, Lingjing Chen, Richard Locksley, Clifford Lowell, James Rubenstein

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma.

Blood

Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C

Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Rubenstein JL, Hsi ED, Johnson JL, Jung SH, Nakashima MO, Grant B, Cheson BD, Kaplan LD

A systematic approach to the diagnosis of suspected central nervous system lymphoma.

JAMA neurology

Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA

Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.

Blood

Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE

BCL6 Expression and Treatment Delay Correlate with Adverse Outcome in Newly Diagnosed Primary CNS Lymphoma: Final Report of CALGB 50202 (Alliance).

Blood

James L. Rubenstein, Eric D. Hsi, Jeffrey L. Johnson, Sin-Ho Jung, Barbara Grant, Bruce D. Cheson, Lawrence D. Kaplan

Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL

Biology of Primary Central Nervous System Lymphoma.

Lymphoma and Leukemia of the Nervous System

James L. Rubenstein

Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,.

Blood

Cigall Kadoch, Valerie Wong, Lingjing Chen, Anna Bet-Lachin, Ritu Roy, William Hyun, Caroline Behler, Clifford Lowell, James L. Rubenstein

Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,.

Blood

Hua-Xin Gao, Shawn Anderson, Lingjing Chen, Cigall Kadoch, Byron C Hann, Clifford Lowell, Colin Collins, James L. Rubenstein

Metabolic Profiling of CNS Lymphoma and Its Microenvironment.

Blood

Anna Bet-Lachin, Frank Jiang, Lingjing Chen, Keyvan Keshari, David Wilson, John Kurhanewicz, James L. Rubenstein

Multicenter Phase I Trial of Intraventricular Immuno-Chemotherapy in Recurrent CNS Lymphoma.

Blood

James L. Rubenstein, Lingjing Chen, Ranjana Advani, Jan Drappatz, Elizabeth Gerstner, Tracy Batchelor, Hendrikus Krouwer, Cigall Kadoch, Pamela Munster, Soonmee Cha, Marc A Shuman, Lloyd E. Damon

Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium.

The oncologist

Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, Cassoux N, Touitou V, Smith JR, Batchelor TT, Pulido JS

Regression of refractory intraocular large B-cell lymphoma with lenalidomide monotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Rubenstein JL, Treseler PA, Stewart PJ

Abstract 2728: Multivariate analysis of cerebrospinal fluid protein biomarkers in central nervous system lymphoma patients and controls.

Clinical Research

Valerie S. Wong, Lingjing Chen, Cigall Kadoch, Anly Tsang, Lisa Siu, Clifford Lowell, James L. Rubenstein

Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma.

Clinical Research

Cigall Kadoch, Valerie S. Wong, Tara C. Rambaldo, William C. Hyun, Hua Xin Gao, Clifford A. Lowell, James L. Rubenstein

Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma.

Blood

Cigall Kadoch, Valerie D. Wong, Tara Rambaldo, William Hyun, Clifford Lowell, James Rubenstein

Biology and treatment of primary central nervous system lymphoma.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Algazi AP, Kadoch C, Rubenstein JL

Reply to H. Zetterberg et al.

Journal of Clinical Oncology

James L. Rubenstein, Lingjing Chen, Cigall Kadoch, Sushmita Roy, Chris Becker, Howard Schulman

Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL

Differential gene expression in central nervous system lymphoma.

Blood

Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA

Insights into the biology of primary central nervous system lymphoma.

Current oncology reports

Mrugala MM, Rubenstein JL, Ponzoni M, Batchelor TT

Sarcoidosis of the pineal gland: an unusual presentation of neurosarcoidosis.

Journal of neuro-oncology

Yang I, Delpolyi A, Sughrue ME, Rubenstein J, Bollen AW, Parsa AT

Chapter 56 Brain Metastases and Neoplastic Meningitis.

Abeloff\u0027s Clinical Oncology

Penny K. Sneed, Norbert Kased, Kim Huang, James L. Rubenstein

Protein biomarker identification in the CSF of patients with CNS lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL

In Reply.

Journal of Clinical Oncology

James Rubenstein, Lauren Abrey, Ranjana Advani, Marc Shuman, Tony Tsai, Joan O'Brien

Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M

Molecular pathogenesis of primary central nervous system lymphoma.

Neurosurgical focus

Kadoch C, Treseler P, Rubenstein JL

Identification of CSF Biomarkers for the Diagnosis of CNS Lymphoma.

Blood

James L. Rubenstein, Cigall Kadoch, Jon Karch, Andrew Josephson, Samar Issa, Chris Becker, Howard Schulman, Lloyd Damon, Marc A. Shuman, Sushmita Roy

Treatment of primary CNS lymphoma with induction high-dose methotrexate, temozolomide, rituximab followed by consolidation cytarabine/etoposide: A pilot study with biomarker analysis.

Journal of Clinical Oncology

S. Issa, J. Hwang, J. Karch, J. Fridlyand, M. Prados, T. Batchelor, K. Aldape, C. Haqq, L. Damon, J. Rubenstein

Gene expression and angiotropism in primary CNS lymphoma.

Blood

Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M

Surgically (laparotomy/laparoscopy) guided placement of high dose rate interstitial irradiation catheters (LG-HDRT): technique and outcome.

Gynecologic oncology

Orr JW, Dosoretz DD, Mahoney D, Roland PY, Kelly FJ, Blitzer P, Nakfoor B, Katin M, Rubenstein J, Boothby RR

Pathology and genetics of primary central nervous system and intraocular lymphoma.

Hematology/oncology clinics of North America

Rubenstein JL, Treseler P, O'Brien JM

Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Shenkier TN, Blay JY, O'Neill BP, Poortmans P, Thiel E, Jahnke K, Abrey LE, Neuwelt E, Tsang R, Batchelor T, Harris N, Ferreri AJ, Ponzoni M, O'Brien P, Rubenstein J, Connors JM

Primary Central Nervous System Lymphoma of T Cell Origin: A Descriptive Analysis of 45 Cases from the International PCNSL Collaborative Group.

Blood

Tamara Shenkier, Jean-Yves Blay, Brian P. O’Neill, Philip Poortmans, Kristoph Janke, Lauren E. Abrey, Edward Neuwelt, Richard Tsang, Tracy Batchelor, Nancy Harris, Andres J. Ferreri, Maurilio Ponzoni, Peter O’Brien, James Rubenstein, Joseph M. Connors

Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis.

Journal of Clinical Oncology

J. L. Rubenstein, A. Shen, L. Abrey, D. Combs, C. Haqq, L. Damon, J. O'Brien, P. O'Connor, M. Prados, M. Shuman

Results from a phase I study of intraventricular administration of rituximab in patients with recurrent lymphomatous meningitis.

Journal of Clinical Oncology

J. L. Rubenstein, A. Shen, L. Abrey, D. Combs, C. Haqq, L. Damon, J. O'Brien, P. O'Connor, M. Prados, M. Shuman

Brain Metastases from Genitourinary Cancer: Germ Cell, Testicular, Prostate and Bladder Cancer.

Intracranial Metastases

Philip V. Theodosopoulos, James L. Rubenstein, Michael W. McDermott

Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment.

Blood

Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA

Hemorrhage and VEGF expression in a case of primary CNS lymphoma.

Journal of neuro-oncology

Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M

Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.

Science (New York, N.Y.)

Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL

Tbr1 regulates differentiation of the preplate and layer 6.

Neuron

Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL

Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons.

Neuron

Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein JL

Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption.

Neoplasia (New York, N.Y.)

Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, Shuman MA

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.

Development (Cambridge, England)

Galceran J, Miyashita-Lin EM, Devaney E, Rubenstein JL, Grosschedl R

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

Development (Cambridge, England)

Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS