
Professor
Psychiatry
+1 415 476-7872
John Rubenstein, MD, PhD explores the origin of inhibitory interneurons in the brain and their possible utility in cell-based therapy for brain disorders such as epilepsy and Parkinson’s disease.
Publications
Combinatorial transcription factor binding encodes cis-regulatory wiring of mouse forebrain GABAergic neurogenesis.
Developmental cell
Nr2f1 enhancers have distinct functions in controlling Nr2f1 expression during cortical development.
Proceedings of the National Academy of Sciences of the United States of America
Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.
Cell reports
DLX genes and proteins in mammalian forebrain development.
Development (Cambridge, England)
De novo variants in the non-coding spliceosomal snRNA gene RNU4-2 are a frequent cause of syndromic neurodevelopmental disorders.
medRxiv : the preprint server for health sciences
Erratum.
The Journal of comparative neurology
Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.
Cell stem cell
Critical test of the assumption that the hypothalamic entopeduncular nucleus of rodents is homologous with the primate internal pallidum.
The Journal of comparative neurology
The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.
Developmental biology
Combinatorial transcription factor binding encodes cis-regulatory wiring of forebrain GABAergic neurogenesis.
bioRxiv : the preprint server for biology
Dorsoventral Arrangement of Lateral Hypothalamus Populations in the Mouse Hypothalamus: a Prosomeric Genoarchitectonic Analysis.
Molecular neurobiology
DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.
Development (Cambridge, England)
Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.
Nature neuroscience
Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.
Proceedings of the National Academy of Sciences of the United States of America
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.
Development (Cambridge, England)
LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
Journal of neurodevelopmental disorders
Transcriptional network orchestrating regional patterning of cortical progenitors.
Proceedings of the National Academy of Sciences of the United States of America
Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.
Cell reports
Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse brain.
Genome medicine
Cracking the Codes of Cortical Glial Progenitors: Evidence for the Common Lineage of Astrocytes and Oligodendrocytes.
Neuroscience bulletin
Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain.
eLife
Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons.
Communications biology
Regulatory Elements Inserted into AAVs Confer Preferential Activity in Cortical Interneurons.
eNeuro
LacZ-reporter mapping of Dlx5/6 expression and genoarchitectural analysis of the postnatal mouse prethalamus.
The Journal of comparative neurology
Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Cell reports
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.
Cell reports
Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons.
Proceedings of the National Academy of Sciences of the United States of America
Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.
Cerebral cortex (New York, N.Y. : 1991)
Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons.
Nature communications
Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons.
Cell reports
Immature excitatory neurons develop during adolescence in the human amygdala.
Nature communications
Sp9 Regulates Medial Ganglionic Eminence-Derived Cortical Interneuron Development.
Cerebral cortex (New York, N.Y. : 1991)
Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders.
Molecular psychiatry
Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer.
Molecular autism
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.
Cell reports
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.
Science (New York, N.Y.)
Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.
Cerebral cortex (New York, N.Y. : 1991)
Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.
Cerebral cortex (New York, N.Y. : 1991)
CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Genomic analysis of transcriptional networks directing progression of cell states during MGE development.
Neural development
Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
Cerebral cortex (New York, N.Y. : 1991)
The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.
Frontiers in neuroscience
SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
Development (Cambridge, England)
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
Cerebral cortex (New York, N.Y. : 1991)
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.
Nature genetics
Tbr1 instructs laminar patterning of retinal ganglion cell dendrites.
Nature neuroscience
Cortical interneuron development: a tale of time and space.
Development (Cambridge, England)
The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex.
Cerebral cortex (New York, N.Y. : 1991)
GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons.
Development (Cambridge, England)
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types.
Scientific reports
Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum.
Cell reports
Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.
Neuron
The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons.
Cell reports
TBR1 regulates autism risk genes in the developing neocortex.
Genome research
Radial derivatives of the mouse ventral pallium traced with Dbx1-LacZ reporters.
Journal of chemical neuroanatomy
Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor.
Molecular biology and evolution
Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis.
Developmental cell
EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex.
Development (Cambridge, England)
Fgf15 regulates thalamic development by controlling the expression of proneural genes.
Brain structure & function
Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development.
The Journal of comparative neurology
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.
Cell reports
Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.
Human molecular genetics
The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.
Cell reports
Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies.
Journal of visualized experiments : JoVE
Molecular codes defining rostrocaudal domains in the embryonic mouse hypothalamus.
Frontiers in neuroanatomy
Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
Neural development
A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model.
Frontiers in neuroanatomy
An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females.
Cell reports
Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.
Developmental cell
A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with A� accumulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Major progress towards elucidating brain wiring diagrams.
The Journal of comparative neurology
Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex.
Neuron
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.
Neuron
Interneurons from embryonic development to cell-based therapy.
Science (New York, N.Y.)
Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex.
Neural development
Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition.
Neuron
Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Many human accelerated regions are developmental enhancers.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon.
Developmental biology
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences.
Nature neuroscience
Subcortical origins of human and monkey neocortical interneurons.
Nature neuroscience
A subpopulation of individual neural progenitors in the mammalian dorsal pallium generates both projection neurons and interneurons in vitro.
Stem cells (Dayton, Ohio)
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior.
Nature neuroscience
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.
Cell stem cell
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
American journal of human genetics
Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.
The Journal of comparative neurology
Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders.
Nature reviews. Neuroscience
New insights into the classification and nomenclature of cortical GABAergic interneurons.
Nature reviews. Neuroscience
Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons.
The Journal of comparative neurology
Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.
Cerebral cortex (New York, N.Y. : 1991)
Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate.
Developmental dynamics : an official publication of the American Association of Anatomists
Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development.
Proceedings of the National Academy of Sciences of the United States of America
Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.
Nature
Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.
Proceedings of the National Academy of Sciences of the United States of America
COUP-TFII controls amygdala patterning by regulating neuropilin expression.
Development (Cambridge, England)
TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.
Stem cells and development
A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8.
Cerebral cortex (New York, N.Y. : 1991)
Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala.
The Journal of comparative neurology
Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex.
Cerebral cortex (New York, N.Y. : 1991)
No paradox, no progress: inverse cancer comorbidity in people with other complex diseases.
The Lancet. Oncology
Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.
Journal of neurophysiology
Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Identification of direct downstream targets of Dlx5 during early inner ear development.
Human molecular genetics
Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.
Development (Cambridge, England)
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.
Nature
Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders.
Journal of child psychology and psychiatry, and allied disciplines
An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain.
Development (Cambridge, England)
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.
Neuron
Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
Proceedings of the National Academy of Sciences of the United States of America
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder.
Current opinion in neurology
Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Erratum to: Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development.
Journal of neurodevelopmental disorders
The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons.
The Journal of comparative neurology
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.
Developmental biology
Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.
Development (Cambridge, England)
Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development.
Journal of neurodevelopmental disorders
Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice.
The Journal of comparative neurology
Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America
The organization of the transcriptional network in specific neuronal classes.
Molecular systems biology
Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons.
Journal of neurodevelopmental disorders
Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Cerebral cortex (New York, N.Y. : 1991)
Genes and signaling events that establish regional patterning of the mammalian forebrain.
Seminars in cell & developmental biology
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.
The Journal of comparative neurology
Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons.
Molecular and cellular neurosciences
Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.
The Journal of comparative neurology
Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.
Development (Cambridge, England)
Functional disturbances in the striatum by region-specific ablation of NMDA receptors.
Proceedings of the National Academy of Sciences of the United States of America
Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer.
Developmental biology
Distal-less homeobox transcription factors regulate development and maturation of natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America
FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.
Neural development
Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2.
The Journal of comparative neurology
Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain.
Nature neuroscience
Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development.
The Journal of comparative neurology
COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.
Cerebral cortex (New York, N.Y. : 1991)
Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods.
Brain research bulletin
Abnormal social behaviors in mice lacking Fgf17.
Genes, brain, and behavior
Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes.
The Journal of neuroscience : the official journal of the Society for Neuroscience
A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Patterning of frontal cortex subdivisions by Fgf17.
Proceedings of the National Academy of Sciences of the United States of America
Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Genetic regulation of prefrontal cortex development and function.
Novartis Foundation symposium
The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological function.
Journal of molecular biology
Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cellular patterns of transcription factor expression in developing cortical interneurons.
Cerebral cortex (New York, N.Y. : 1991)
Can autism speak to neuroscience?
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.
Development (Cambridge, England)
Severe hearing loss in Dlxl mutant mice.
Hearing research
New neurons follow the flow of cerebrospinal fluid in the adult brain.
Science (New York, N.Y.)
Patterning and plasticity of the cerebral cortex.
Science (New York, N.Y.)
Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development.
Journal of anatomy
Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy.
Nature neuroscience
The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain.
The Journal of comparative neurology
The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells.
Brain research bulletin
Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families.
The Journal of biological chemistry
Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina.
Development (Cambridge, England)
Identification of Tbr-1/CASK complex target genes in neurons.
Journal of neurochemistry
Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon.
Developmental dynamics : an official publication of the American Association of Anatomists
Fgf8 regulates the development of intra-neocortical projections.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Id4 regulates neural progenitor proliferation and differentiation in vivo.
Development (Cambridge, England)
Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey.
The Journal of comparative neurology
Intermediate targets in formation of topographic projections: inputs from the thalamocortical system.
Trends in neurosciences
Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex.
The Journal of comparative neurology
Origins of cortical interneuron subtypes.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor.
Development (Cambridge, England)
Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4.
Development (Cambridge, England)
Model of autism: increased ratio of excitation/inhibition in key neural systems.
Genes, brain, and behavior
Forebrain gene expression domains and the evolving prosomeric model.
Trends in neurosciences
The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain.
Proceedings of the National Academy of Sciences of the United States of America
Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia.
The Journal of comparative neurology
Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction.
Development (Cambridge, England)
Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.
Molecular and cellular neurosciences
Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants.
Development (Cambridge, England)
Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding.
The Journal of comparative neurology
Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons.
Developmental neuroscience
Cell migration in the forebrain.
Annual review of neuroscience
Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain.
Proceedings of the National Academy of Sciences of the United States of America
DLX5 regulates development of peripheral and central components of the olfactory system.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice.
Development (Cambridge, England)
Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.
Development (Cambridge, England)
Developmental functions of the Distal-less/Dlx homeobox genes.
Development (Cambridge, England)
Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Specification of jaw subdivisions by Dlx genes.
Science (New York, N.Y.)
Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis.
Mechanisms of development
Distinct origins of neocortical projection neurons and interneurons in vivo.
Cerebral cortex (New York, N.Y. : 1991)
Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other.
The Journal of comparative neurology
Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections.
Development (Cambridge, England)
Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression.
Development (Cambridge, England)
Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons.
Cerebral cortex (New York, N.Y. : 1991)
A long, remarkable journey: tangential migration in the telencephalon.
Nature reviews. Neuroscience
Fate map of the avian anterior forebrain at the four-somite stage, based on the analysis of quail-chick chimeras.
Developmental biology
Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins.
Brain research. Developmental brain research
Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.
Development (Cambridge, England)
Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.
Science (New York, N.Y.)
Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor.
Development (Cambridge, England)
Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH.
Development (Cambridge, England)
Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2.
DNA and cell biology
Chicken Nkx6.1 expression at advanced stages of development identifies distinct brain nuclei derived from the basal plate.
Mechanisms of development
Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Distinct cortical migrations from the medial and lateral ganglionic eminences.
Development (Cambridge, England)
Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon.
Development (Cambridge, England)
Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates.
Genes & development
Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1.
The Journal of comparative neurology
Origin and molecular specification of striatal interneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.
Development (Cambridge, England)
A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch.
Development (Cambridge, England)
Intrinsic and extrinsic control of cortical development.
Novartis Foundation symposium
The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex.
Novartis Foundation symposium
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch.
Genes & development
DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation.
The Journal of comparative neurology
Differential origins of neocortical projection and local circuit neurons: role of Dlx genes in neocortical interneuronogenesis.
Cerebral cortex (New York, N.Y. : 1991)
Dlx5 regulates regional development of the branchial arches and sensory capsules.
Development (Cambridge, England)
Genetic control of cortical development.
Cerebral cortex (New York, N.Y. : 1991)
Genetic control of cortical regionalization and connectivity.
Cerebral cortex (New York, N.Y. : 1991)
Early neocortical regionalization in the absence of thalamic innervation.
Science (New York, N.Y.)
Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.
Development (Cambridge, England)
Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development.
Mechanisms of development
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.
Nature
Comparison of the mammalian and avian telencephalon from the perspective of gene expression data.
European journal of morphology
Cyclic nucleotide-gated cation channel expression in embryonic chick brain.
Brain research. Molecular brain research
Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly.
Proceedings of the National Academy of Sciences of the United States of America
FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression.
Development (Cambridge, England)
Induction of the epibranchial placodes.
Development (Cambridge, England)
Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells.
The Journal of comparative neurology
Association of MSX1 and TGFB3 with nonsyndromic clefting in humans.
American journal of human genetics
Development of serotonergic neurons and their projections.
Biological psychiatry
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Development (Cambridge, England)
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate.
Cell
Development of the cerebral cortex: V. Transcription factors and brain development.
Journal of the American Academy of Child and Adolescent Psychiatry
Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development.
Mechanisms of development
Patterning of the embryonic forebrain.
Current opinion in neurobiology
Molecular control of odontogenic patterning: positional dependent initiation and morphogenesis.
European journal of oral sciences
Regionalization of the prosencephalic neural plate.
Annual review of neuroscience
Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists
Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition.
Development (Cambridge, England)
Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.
Science (New York, N.Y.)
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function.
Development (Cambridge, England)
Inductive interactions direct early regionalization of the mouse forebrain.
Development (Cambridge, England)
ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia.
Journal of molecular neuroscience : MN
Workshop on schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America
Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains.
Developmental neuroscience
Mutation of the Emx-1 homeobox gene disrupts the corpus callosum.
Developmental biology
Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Molecular and cellular neurosciences
Longitudinal organization of the anterior neural plate and neural tube.
Development (Cambridge, England)
Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.
Genes & development
Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.
Endocrinology
Id gene expression during development and molecular cloning of the human Id-1 gene.
Brain research. Molecular brain research
The spatial localization of Dlx-2 during tooth development.
Connective tissue research
DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The embryonic vertebrate forebrain: the prosomeric model.
Science (New York, N.Y.)
Homeobox gene expression during development of the vertebrate brain.
Current topics in developmental biology
Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization.
Trends in neurosciences
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos.
Mechanisms of development
Isolation and characterization of a library of cDNA clones that are preferentially expressed in the embryonic telencephalon.
Brain research. Molecular brain research
Subtractive hybridization system using single-stranded phagemids with directional inserts.
Nucleic acids research
Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.
The EMBO journal
Introduction of genes into preimplantation mouse embryos by use of a defective recombinant retrovirus.
Proceedings of the National Academy of Sciences of the United States of America
Introduction of genes into embryonal carcinoma cells and preimplantation embryos by retroviral vectors.
Cold Spring Harbor symposia on quantitative biology
Construction of a retrovirus capable of transducing and expressing genes in multipotential embryonic cells.
Proceedings of the National Academy of Sciences of the United States of America
[Nonsense RNA: a tool for specifically inhibiting the expression of a gene in vivo].
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie
Construction of a synthetic messenger RNA encoding a membrane protein.
The Journal of cell biology
Purification of coated vesicles by agarose gel electrophoresis.
The Journal of cell biology
Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol.
Biochemistry
Lateral diffusion in binary mixtures of cholesterol and phosphatidylcholines.
Proceedings of the National Academy of Sciences of the United States of America