 
Professor
          Medicine
          +1 415 750-2089
      Robert Nissenson, PhD studies the role of signaling pathways in the development of bone depositing osteoblasts.
Publications
Blockade of Gi Signaling Enhances the Anabolic Effect of Parathyroid Hormone in Female Mice.
Calcified tissue international
      
            
      
      Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery.
Bone reports
      
            
      
      Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Nature communications
      
            
      
      Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.
Endocrinology
      
            
      
      Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
      
            
      
      Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury.
Muscles, ligaments and tendons journal
      
            
      
      Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice.
The Journal of nutritional biochemistry
      
            
      
      Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
      
            
      
      Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.
Experimental cell research
      
            
      
      Novel mouse model of spinal cord injury-induced heterotopic ossification.
Journal of rehabilitation research and development
      
            
      
      A novel mouse model of trauma induced heterotopic ossification.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
      
            
      
      CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
      
            
      
      Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.
Calcified tissue international
      
            
      
      Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells.
Tissue engineering. Part A
      
            
      
      Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Engineering GPCR signaling pathways with RASSLs.
Nature methods
      
            
      
      Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.
Endocrinology
      
            
      
      Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy.
American journal of physiology. Heart and circulatory physiology
      
            
      
      PTH differentially regulates expression of RANKL and OPG.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association.
The Journal of biological chemistry
      
            
      
      Analysis of parathyroid hormone (PTH)/secretin receptor chimeras differentiates the role of functional domains in the pth/ pth-related peptide (PTHrP) receptor on hormone binding and receptor activation.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein.
The Journal of biological chemistry
      
            
      
      Mitogenic G(i) protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP.
Journal of cellular biochemistry
      
            
      
      Parathyroid hormone-related protein.
Reviews in endocrine & metabolic disorders
      
            
      
      Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function.
Bone
      
            
      
      Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP).
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.
The Journal of biological chemistry
      
            
      
      Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Transmembrane residues together with the amino terminus limit the response of the parathyroid hormone (PTH) 2 receptor to PTH-related peptide.
The Journal of biological chemistry
      
            
      
      Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways.
The Journal of biological chemistry
      
            
      
      Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.
Endocrinology
      
            
      
      Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion.
The Journal of biological chemistry
      
            
      
      Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein.
Endocrinology
      
            
      
      Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis.
The Journal of biological chemistry
      
            
      
      Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      A novel phospholipase C inhibitor and phorbol esters reveal selective regulation of thrombin- and parathyroid hormone-stimulated signaling pathways in rat osteosarcoma cells.
The Journal of pharmacology and experimental therapeutics
      
            
      
      Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient.
The Journal of clinical endocrinology and metabolism
      
            
      
      Actions of parathyroid hormone-related protein as an embryonic differentiation factor.
Journal of endocrinological investigation
      
            
      
      Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones.
The Journal of pharmacology and experimental therapeutics
      
            
      
      Thrombin and parathyroid hormone mobilize intracellular calcium in rat osteosarcoma cells by distinct pathways.
Endocrinology
      
            
      
      Chicken parathyroid hormone-related protein and its expression during embryologic development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Features of the renal parathyroid hormone-parathyroid hormone-related protein receptor derived from structural studies of receptor fragments.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone.
The Journal of biological chemistry
      
            
      
      Desensitization of parathyroid hormone receptors on cultured bone cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Hypercalcemia in malignancy.
The Western journal of medicine
      
            
      
      Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells.
The Journal of biological chemistry
      
            
      
      Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells.
Molecular endocrinology (Baltimore, Md.)
      
            
      
      Peptide mediators of hypercalcemia in malignancy.
Annual review of medicine
      
            
      
      Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia.
Annals of internal medicine
      
            
      
      High levels of a parathyroid hormone-like protein in milk.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Structural properties of the renal parathyroid hormone receptor: hydrodynamic analysis and protease sensitivity.
Endocrinology
      
            
      
      Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.
The Journal of biological chemistry
      
            
      
      Parathyroid hormone receptors in human dermal fibroblasts: structural and functional characterization.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro.
Bone and mineral
      
            
      
      Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
The Journal of clinical investigation
      
            
      
      The canine renal parathyroid hormone receptor is a glycoprotein: characterization and partial purification.
Biochemistry
      
            
      
      Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
      
            
      
      Nonparathyroid hypercalcemia.
Advances in internal medicine
      
            
      
      Dual regulation of PTH-stimulated adenylate cyclase activity by GTP.
The American journal of physiology
      
            
      
      Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex.
Endocrinology
      
            
      
      Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex.
Advances in experimental medicine and biology
      
            
      
      Structural requirements for parathyroid hormone action in mature bone. Effects on release of cyclic adenosine monophosphate and bone gamma-carboxyglutamic acid-containing protein from perfused rat hindquarters.
The Journal of clinical investigation
      
            
      
      Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor.
Cancer research
      
            
      
      Human transforming growth factor-alpha stimulates bone resorption in vitro.
The Journal of clinical investigation
      
            
      
      Influence of continuous infusion of citrate on responses of immunoreactive parathyroid hormone, calcium and magnesium components, and other electrolytes in normal adults during plateletapheresis.
The Journal of clinical endocrinology and metabolism
      
            
      
      Assay for parathyroid hormone receptors.
Methods in enzymology
      
            
      
      Assays for calcitonin receptors.
Methods in enzymology
      
            
      
      Mechanisms for increased adenylate cyclase responsiveness to TSH in neoplastic human thyroid tissue.
World journal of surgery
      
            
      
      High-performance liquid chromatographic methods for the analysis of human parathyroid hormone in reference standards, parathyroid tissue and biological fluids.
Journal of chromatography
      
            
      
      Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone.
The Journal of clinical investigation
      
            
      
      Characterization of the thyrotropin receptor-adenylate cyclase system in neoplastic human thyroid tissue.
The Journal of clinical endocrinology and metabolism
      
            
      
      Effect of plasma calcium concentration on the metabolic clearance rate of parathyroid hormone in the dog.
The Journal of laboratory and clinical medicine
      
            
      
      Preparation of synthetic bovine parathyroid hormone fragment 1-34 for parenteral use in human studies.
The Journal of clinical endocrinology and metabolism
      
            
      
      Functional profile of the isolated uremic nephron: intrinsic adaptation of phosphate transport in the rabbit proximal tubule.
Kidney international
      
            
      
      Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors.
The Journal of clinical investigation
      
            
      
      Functional properties of parathyroid hormone receptors.
Mineral and electrolyte metabolism
      
            
      
      Thyrotropin binding and adenylate cyclase activation in normal and neoplastic human thyroid tissue: lack of effect of thyroglobulin.
The Journal of clinical endocrinology and metabolism
      
            
      
      Photoaffinity labeling of the canine renal receptor for parathyroid hormone.
The Journal of biological chemistry
      
            
      
      Assessment of biologically active parathyroid hormone in hyperparathyroid man.
Advances in experimental medicine and biology
      
            
      
      Functional properties of parathyroid hormone receptors in kidney and bone.
Advances in experimental medicine and biology
      
            
      
      Endogenous biologically active human parathyroid hormone: measurement by a guanyl nucleotide-amplified renal adenylate cyclase assay.
The Journal of clinical endocrinology and metabolism
      
            
      
      Oxytocin receptors coupled to uterine contraction in estrogen-dominated rabbits.
Biochimica et biophysica acta
      
            
      
      Biologically active parathyroid hormone in human hyperparathyroid serum: assay and characterization.
Transactions of the Association of American Physicians
      
            
      
      The parathyroid hormone receptor-adenylate cyclase system in chicken kidney.
Advances in experimental medicine and biology
      
            
      
      The renal parathyroid hormone receptor-adenylate cyclase system in vitro and in vivo.
Progress in biochemical pharmacology
      
            
      
      Properties of the parathyroid hormone receptor-adenylate cyclase system in chicken renal plasma membranes.
The Journal of biological chemistry
      
            
      
      Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Parathyroid hormone receptors and stimulation of renal cyclic 3', 5' AMP in vitro: physiological relevance?
Advances in experimental medicine and biology
      
            
      
      