
Professor
Medicine
+1 415 750-2089
Robert Nissenson, PhD studies the role of signaling pathways in the development of bone depositing osteoblasts.
Publications
Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery.
Bone reports
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.
Nature communications
Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.
Endocrinology
Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury.
Muscles, ligaments and tendons journal
Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice.
The Journal of nutritional biochemistry
Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.
Experimental cell research
Novel mouse model of spinal cord injury-induced heterotopic ossification.
Journal of rehabilitation research and development
A novel mouse model of trauma induced heterotopic ossification.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.
Calcified tissue international
Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells.
Tissue engineering. Part A
Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation.
Molecular endocrinology (Baltimore, Md.)
Engineering GPCR signaling pathways with RASSLs.
Nature methods
Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.
Proceedings of the National Academy of Sciences of the United States of America
Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.
Endocrinology
Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy.
American journal of physiology. Heart and circulatory physiology
PTH differentially regulates expression of RANKL and OPG.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin.
Molecular endocrinology (Baltimore, Md.)
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association.
The Journal of biological chemistry
Analysis of parathyroid hormone (PTH)/secretin receptor chimeras differentiates the role of functional domains in the pth/ pth-related peptide (PTHrP) receptor on hormone binding and receptor activation.
Molecular endocrinology (Baltimore, Md.)
Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein.
The Journal of biological chemistry
Mitogenic G(i) protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP.
Journal of cellular biochemistry
Parathyroid hormone-related protein.
Reviews in endocrine & metabolic disorders
Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function.
Bone
Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP).
Molecular endocrinology (Baltimore, Md.)
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation.
The Journal of biological chemistry
Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization.
Molecular endocrinology (Baltimore, Md.)
Transmembrane residues together with the amino terminus limit the response of the parathyroid hormone (PTH) 2 receptor to PTH-related peptide.
The Journal of biological chemistry
Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.
Molecular endocrinology (Baltimore, Md.)
The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways.
The Journal of biological chemistry
Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.
Endocrinology
Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells.
Molecular endocrinology (Baltimore, Md.)
Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion.
The Journal of biological chemistry
Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.)
Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein.
Endocrinology
Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling.
Molecular endocrinology (Baltimore, Md.)
The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis.
The Journal of biological chemistry
Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
A novel phospholipase C inhibitor and phorbol esters reveal selective regulation of thrombin- and parathyroid hormone-stimulated signaling pathways in rat osteosarcoma cells.
The Journal of pharmacology and experimental therapeutics
Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient.
The Journal of clinical endocrinology and metabolism
Actions of parathyroid hormone-related protein as an embryonic differentiation factor.
Journal of endocrinological investigation
Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones.
The Journal of pharmacology and experimental therapeutics
Thrombin and parathyroid hormone mobilize intracellular calcium in rat osteosarcoma cells by distinct pathways.
Endocrinology
Chicken parathyroid hormone-related protein and its expression during embryologic development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Features of the renal parathyroid hormone-parathyroid hormone-related protein receptor derived from structural studies of receptor fragments.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone.
The Journal of biological chemistry
Desensitization of parathyroid hormone receptors on cultured bone cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Hypercalcemia in malignancy.
The Western journal of medicine
Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells.
The Journal of biological chemistry
Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells.
Molecular endocrinology (Baltimore, Md.)
Peptide mediators of hypercalcemia in malignancy.
Annual review of medicine
Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia.
Annals of internal medicine
High levels of a parathyroid hormone-like protein in milk.
Proceedings of the National Academy of Sciences of the United States of America
G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Structural properties of the renal parathyroid hormone receptor: hydrodynamic analysis and protease sensitivity.
Endocrinology
Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.
The Journal of biological chemistry
Parathyroid hormone receptors in human dermal fibroblasts: structural and functional characterization.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro.
Bone and mineral
Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene.
Proceedings of the National Academy of Sciences of the United States of America
Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
The Journal of clinical investigation
The canine renal parathyroid hormone receptor is a glycoprotein: characterization and partial purification.
Biochemistry
Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Nonparathyroid hypercalcemia.
Advances in internal medicine
Dual regulation of PTH-stimulated adenylate cyclase activity by GTP.
The American journal of physiology
Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex.
Endocrinology
Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex.
Advances in experimental medicine and biology
Structural requirements for parathyroid hormone action in mature bone. Effects on release of cyclic adenosine monophosphate and bone gamma-carboxyglutamic acid-containing protein from perfused rat hindquarters.
The Journal of clinical investigation
Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor.
Cancer research
Human transforming growth factor-alpha stimulates bone resorption in vitro.
The Journal of clinical investigation
Influence of continuous infusion of citrate on responses of immunoreactive parathyroid hormone, calcium and magnesium components, and other electrolytes in normal adults during plateletapheresis.
The Journal of clinical endocrinology and metabolism
Assay for parathyroid hormone receptors.
Methods in enzymology
Assays for calcitonin receptors.
Methods in enzymology
Mechanisms for increased adenylate cyclase responsiveness to TSH in neoplastic human thyroid tissue.
World journal of surgery
High-performance liquid chromatographic methods for the analysis of human parathyroid hormone in reference standards, parathyroid tissue and biological fluids.
Journal of chromatography
Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone.
The Journal of clinical investigation
Characterization of the thyrotropin receptor-adenylate cyclase system in neoplastic human thyroid tissue.
The Journal of clinical endocrinology and metabolism
Effect of plasma calcium concentration on the metabolic clearance rate of parathyroid hormone in the dog.
The Journal of laboratory and clinical medicine
Preparation of synthetic bovine parathyroid hormone fragment 1-34 for parenteral use in human studies.
The Journal of clinical endocrinology and metabolism
Functional profile of the isolated uremic nephron: intrinsic adaptation of phosphate transport in the rabbit proximal tubule.
Kidney international
Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors.
The Journal of clinical investigation
Functional properties of parathyroid hormone receptors.
Mineral and electrolyte metabolism
Thyrotropin binding and adenylate cyclase activation in normal and neoplastic human thyroid tissue: lack of effect of thyroglobulin.
The Journal of clinical endocrinology and metabolism
Photoaffinity labeling of the canine renal receptor for parathyroid hormone.
The Journal of biological chemistry
Assessment of biologically active parathyroid hormone in hyperparathyroid man.
Advances in experimental medicine and biology
Functional properties of parathyroid hormone receptors in kidney and bone.
Advances in experimental medicine and biology
Endogenous biologically active human parathyroid hormone: measurement by a guanyl nucleotide-amplified renal adenylate cyclase assay.
The Journal of clinical endocrinology and metabolism
Oxytocin receptors coupled to uterine contraction in estrogen-dominated rabbits.
Biochimica et biophysica acta
Biologically active parathyroid hormone in human hyperparathyroid serum: assay and characterization.
Transactions of the Association of American Physicians
The parathyroid hormone receptor-adenylate cyclase system in chicken kidney.
Advances in experimental medicine and biology
The renal parathyroid hormone receptor-adenylate cyclase system in vitro and in vivo.
Progress in biochemical pharmacology
Properties of the parathyroid hormone receptor-adenylate cyclase system in chicken renal plasma membranes.
The Journal of biological chemistry
Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus.
Proceedings of the National Academy of Sciences of the United States of America
Parathyroid hormone receptors and stimulation of renal cyclic 3', 5' AMP in vitro: physiological relevance?
Advances in experimental medicine and biology