Amar Nijagal, MD

Associate Professor
Surgery
+1 415 476-4086

Amar Nijagal, MD investigates how the immune system affects the development of fetal tissues. His research focuses on liver and bile duct development and how immune cells and their hematopoietic progenitors contribute to the pathogenesis of pediatric liver disease.

Publications: 

Perinatal liver inflammation is associated with persistent elevation of CXCL10 and its canonical receptor CXCR3 on common myeloid progenitors.

bioRxiv : the preprint server for biology

Alkhani A, Baskaran S, Murti A, Rapp B, Levy CS, Wang B, Nijagal A

Index admission cholecystectomy for acute cholecystitis reduces 30-day readmission rates in pediatric patients.

Surgical endoscopy

Pathak SJ, Ji H, Nijagal A, Avila P, Dai SC, Arain MA, Kouanda A

Neonatal Hepatic Myeloid Progenitors Expand and Propagate Liver Injury in Mice.

Journal of clinical medicine

Alkhani A, Korsholm C, Levy CS, Mohamedaly S, Duwaerts CC, Pietras EM, Nijagal A

Advances in the Treatment of Neonatal Biliary Disease.

Clinics in perinatology

Mohamedaly S, Nijagal A

Hepatic Ly6CLo Non-Classical Monocytes Have Increased Nr4a1 (Nur77) in Murine Biliary Atresia.

Journal of clinical medicine

Mohamedaly S, Levy CS, Korsholm C, Alkhani A, Rosenberg K, Ashouri JF, Nijagal A

Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids.

Nature communications

Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B

The need for early Kasai portoenterostomy: a Western Pediatric Surgery Research Consortium study.

Pediatric surgery international

Kelley-Quon LI, Shue E, Burke RV, Smith C, Kling K, Mahdi E, Ourshalimian S, Fenlon M, Dellinger M, Shew SB, Lee J, Padilla B, Inge T, Roach J, Marwan AI, Russell KW, Ignacio R, Fialkowski E, Nijagal A, Im C, Azarow KS, Ostlie DJ, Wang K

The Role of Myeloid Populations during Perinatal Liver Injury and Repair.

Journal of cellular immunology

Alkhani A, Mohamedaly S, Nijagal A

The natural history of fetal gallstones: a case series and updated literature review.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Schwab ME, Braun HJ, Feldstein VA, Nijagal A

The relative abundance of monocyte subsets determines susceptibility to perinatal hepatic inflammation.

Journal of clinical & cellular immunology

Mohamedaly S, Alkhani A, Nijagal A

Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

Scientific reports

Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A

Natural history of acute pediatric iliofemoral artery thrombosis treated with anticoagulation.

Journal of vascular surgery

Ramirez JL, Kuhrau CR, Wu B, Zarkowsky DS, Conte MS, Oskowitz AZ, Nijagal A, Vartanian SM

De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.

Journal of pediatric surgery

Schwab ME, Song H, Mattis A, Phelps A, Vu LT, Huang FW, Nijagal A

Congenital superior mesenteric artery aneurysm in a 6-week-old infant presenting with upper gastrointestinal bleeding.

Journal of vascular surgery

Subbaraj L, Beleniski F, Courtier J, Vartanian S, Nijagal A

Treating Biliary Atresia: The Challenge Continues.

Journal of pediatric gastroenterology and nutrition

Nijagal A, Perito ER

Editorial: Treating Biliary Atresia: The Challenge Continues.

Journal of pediatric gastroenterology and nutrition

Nijagal A, Perito ER

Late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature.

Pediatric surgery international

Wolf LL, Nijagal A, Flores A, Buchmiller TL

Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.

Journal of immunology (Baltimore, Md. : 1950)

Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC

Clinical implications of maternal-fetal cellular trafficking.

Seminars in pediatric surgery

Nijagal A, MacKenzie TC

The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases.

Journal of pediatric surgery

Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC

Alterations in maternal-fetal cellular trafficking after fetal surgery.

Journal of pediatric surgery

Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, MacKenzie TC

Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome.

Journal of pediatric surgery

Saadai P, Jelin EB, Nijagal A, Schecter SC, Hirose S, MacKenzie TC, Rand L, Goldstein R, Farrell J, Harrison M, Lee H

In utero hematopoietic cell transplantation for the treatment of congenital anomalies.

Clinics in perinatology

Nijagal A, Flake AW, MacKenzie TC

Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, MacKenzie TC

Pancreatic mesenchyme regulates epithelial organogenesis throughout development.

PLoS biology

Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M

Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia.

Journal of pediatric surgery

Jelin EB, Etemadi M, Encinas J, Schecter SC, Chapin C, Wu J, Guevara-Gallardo S, Nijagal A, Gonzales KD, Ferrier WT, Roy S, Miniati D

A mouse model of in utero transplantation.

Journal of visualized experiments : JoVE

Nijagal A, Le T, Wegorzewska M, Mackenzie TC

Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.

The Journal of clinical investigation

Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC

Intrauterine umbilical cord hemorrhage with associated jejunal atresia captured by real-time ultrasound.

American journal of obstetrics and gynecology

Nijagal A, Rand L, Goldstein R, Poder L, Miniati D

Colonic atresia and choledochal cyst: a rare combination.

Pediatric surgery international

Nijagal A, Ozgediz D, Feldstein VA, Lee H, Harrison MR

Molecular markers for gastric adenocarcinoma: an update.

Molecular diagnosis & therapy

Anderson C, Nijagal A, Kim J

Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor.

Molecular and cellular biology

Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON

Visualization of a primary anti-tumor immune response by positron emission tomography.

Proceedings of the National Academy of Sciences of the United States of America

Shu CJ, Guo S, Kim YJ, Shelly SM, Nijagal A, Ray P, Gambhir SS, Radu CG, Witte ON

Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.

Proceedings of the National Academy of Sciences of the United States of America

Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON

Spontaneous resolution of prenatal megalourethra.

Journal of pediatric surgery

Nijagal A, Sydorak RM, Feldstein VA, Hirose S, Albanese CT

Gastroschisis: small hole, big cost.

Journal of pediatric surgery

Sydorak RM, Nijagal A, Sbragia L, Hirose S, Tsao K, Phibbs RH, Schmitt SK, Lee H, Farmer DL, Harrison MR, Albanese CT

Endoscopic techniques in fetal surgery.

Yonsei medical journal

Sydorak RM, Nijagal A, Albanese CT