
Assistant Professor
Institute for Neurodegenerative Diseases
Daniel Mordes, MD, PhD investigates the molecular mechanisms of neurodegenerative diseases, including ALS and dementia, using stem cell-based models and single-cell analyses of brain areas.
Publications
C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7.
Acta neuropathologica communications
Cryo-EM structure of a novel a-synuclein filament subtype from multiple system atrophy.
FEBS letters
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.
Nature communications
Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs.
bioRxiv : the preprint server for biology
Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
bioRxiv : the preprint server for biology
Running up that pill for amyotrophic lateral sclerosis.
Brain : a journal of neurology
Pluripotent stem cell strategies for rebuilding the human brain.
Frontiers in aging neuroscience
Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein.
Acta neuropathologica
Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.
PLoS pathogens
Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.
Nature neuroscience
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.
Nature neuroscience
Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.
Acta neuropathologica
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
Nature neuroscience
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.
Acta neuropathologica communications
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.
Genes & development
Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
Proceedings of the National Academy of Sciences of the United States of America
MSA prions exhibit remarkable stability and resistance to inactivation.
Acta neuropathologica
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging.
Nature communications
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
Science translational medicine
A 34-Year-Old Male with An Intracranial Mass.
Brain pathology (Zurich, Switzerland)
Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.
Scientific reports
Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock.
The New England journal of medicine
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
Proceedings of the National Academy of Sciences of the United States of America
Propagation of prions causing synucleinopathies in cultured cells.
Proceedings of the National Academy of Sciences of the United States of America
Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia.
The New England journal of medicine
VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.
American journal of clinical pathology
Glioblastoma mimicking an arteriovenous malformation.
Frontiers in neurology
Cytopathology of subacute thyroiditis.
Diagnostic cytopathology
A workshop on leadership for MD/PhD students.
Medical education online
In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene.
Current eye research
Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve.
Current eye research
Dpb11 activates the Mec1-Ddc2 complex.
Proceedings of the National Academy of Sciences of the United States of America
The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.
Molecular and cellular biology
Activation of ATR and related PIKKs.
Cell cycle (Georgetown, Tex.)
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
Genes & development
Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa.
Neurobiology of disease
Function of a conserved checkpoint recruitment domain in ATRIP proteins.
Molecular and cellular biology
Pre-mRNA splicing and retinitis pigmentosa.
Molecular vision