
Professor
CVRI
+1 415 476-3230
Takashi Mikawa, PhD studies the development of the cardiac conduction system during early embryogenesis and the signals that distinguish conduction cells from working myocytes using the chick system.
Publications
Bilateral cellular flows display asymmetry prior to left-right organizer formation in amniote gastrulation.
Proceedings of the National Academy of Sciences of the United States of America
Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
Cellular flows initiate left-right patterning prior to laterality gene expression in amniotes.
bioRxiv : the preprint server for biology
Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension.
bioRxiv : the preprint server for biology
Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.
Research square
Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle.
bioRxiv : the preprint server for biology
Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation.
bioRxiv : the preprint server for biology
Population Analysis of Daptomycin-non-Susceptible Methicillin-Resistant Staphylococcus aureus Reveals the Presence of Variants That Contribute to Daptomycin Resistance.
Current microbiology
Mitotic Antipairing of Homologous Chromosomes.
Results and problems in cell differentiation
Avians as a Model System of Vascular Development.
Methods in molecular biology (Clifton, N.J.)
Programmed cell death along the midline axis patterns ipsilaterality in gastrulation.
Science (New York, N.Y.)
Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets.
Proceedings of the National Academy of Sciences of the United States of America
Dynamic Cellular Integration Drives Functional Assembly of the Heart's Pacemaker Complex.
Cell reports
Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration.
Developmental biology
Chromosome Painting of Mouse Chromosomes.
Methods in molecular biology (Clifton, N.J.)
Avians as a model system of vascular development.
Methods in molecular biology (Clifton, N.J.)
Early divergence of central and peripheral neural retina precursors during vertebrate eye development.
Developmental dynamics : an official publication of the American Association of Anatomists
Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction.
Development (Cambridge, England)
Induction of the Proepicardium.
Journal of developmental biology
Isolation and culture of mouse proepicardium using serum-free conditions.
Methods (San Diego, Calif.)
Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field.
Science (New York, N.Y.)
Early arterial differentiation and patterning in the avian embryo model.
Seminars in cell & developmental biology
A dual role for ErbB2 signaling in cardiac trabeculation.
Development (Cambridge, England)
An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis.
Development (Cambridge, England)
BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart.
Developmental cell
Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes.
Development (Cambridge, England)
FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation.
Developmental biology
Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation.
Developmental biology
Endothelial cell lineages of the heart.
Cell and tissue research
Induction of proepicardial marker gene expression by the liver bud.
Development (Cambridge, England)
Development of the cardiac conduction system.
Seminars in cell & developmental biology
FGF-mediated induction of ciliary body tissue in the chick eye.
Developmental biology
Bone marrow Oct3/4+ cells differentiate into cardiac myocytes via age-dependent paracrine mechanisms.
Circulation research
Enhanced sensitivity and stability in two-color in situ hybridization by means of a novel chromagenic substrate combination.
Developmental dynamics : an official publication of the American Association of Anatomists
TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions.
Developmental biology
VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo.
Circulation research
Normal patterning of the coronary capillary plexus is dependent on the correct transmural gradient of FGF expression in the myocardium.
Developmental biology
Somatic transgenesis in the avian model system.
Birth defects research. Part C, Embryo today : reviews
Developmental transitions in electrical activation patterns in chick embryonic heart.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
A role for Tbx5 in proepicardial cell migration during cardiogenesis.
Physiological genomics
Negative regulation of midline vascular development by the notochord.
Developmental cell
Folding of the tectal cortex by local remodeling of neural differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists
Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote.
Developmental dynamics : an official publication of the American Association of Anatomists
Somatic transgenesis using retroviral vectors in the chicken embryo.
Developmental dynamics : an official publication of the American Association of Anatomists
Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes.
Circulation research
Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart.
Development (Cambridge, England)
Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart.
Developmental dynamics : an official publication of the American Association of Anatomists
Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos.
Developmental dynamics : an official publication of the American Association of Anatomists
Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation.
Developmental biology
Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation.
Developmental biology
His-Purkinje lineages and development.
Novartis Foundation symposium
Induction and patterning of the Purkinje fibre network.
Novartis Foundation symposium
Constitutive expression of preproendothelin in the cardiac neural crest selectively promotes expansion of the adventitia of the great vessels in vivo.
Developmental biology
Development of the coronary vessel system.
Circulation research
Induction and patterning of the cardiac conduction system.
The International journal of developmental biology
Competency of embryonic cardiomyocytes to undergo Purkinje fiber differentiation is regulated by endothelin receptor expression.
Development (Cambridge, England)
Cell death along the embryo midline regulates left-right sidedness.
Developmental dynamics : an official publication of the American Association of Anatomists
Purkinje fibers of the avian heart express a myogenic transcription factor program distinct from cardiac and skeletal muscle.
Developmental biology
TBX5 transcription factor regulates cell proliferation during cardiogenesis.
Developmental biology
Fate diversity of primitive streak cells during heart field formation in ovo.
Developmental dynamics : an official publication of the American Association of Anatomists
Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo.
Developmental biology
Axonal growth of the spinal cord interneurons expressing a homophilic adhesion molecule SC1 ectopically.
Neuroscience research
In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1.
Development (Cambridge, England)
Trk C signaling is required for retinal progenitor cell proliferation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Stable transfectants of smooth muscle cell line lacking the expression of myosin light chain kinase and their characterization with respect to the actomyosin system.
The Journal of biological chemistry
Formation of the avian primitive streak from spatially restricted blastoderm: evidence for polarized cell division in the elongating streak.
Development (Cambridge, England)
Retroviral cell lineage analysis in the developing chick heart.
Methods in molecular biology (Clifton, N.J.)
Induction of Purkinje fiber differentiation by coronary arterialization.
Proceedings of the National Academy of Sciences of the United States of America
Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage.
Development (Cambridge, England)
Identification of chick rax/rx genes with overlapping patterns of expression during early eye and brain development.
Mechanisms of development
Adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor inhibits growth of glioma cells both in vitro and in vivo.
Journal of neuro-oncology
Conducting the embryonic heart: orchestrating development of specialized cardiac tissues.
Trends in cardiovascular medicine
Neural crest cells in outflow tract septation of the embryonic chicken heart: differentiation and apoptosis.
Developmental dynamics : an official publication of the American Association of Anatomists
Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers.
Proceedings of the National Academy of Sciences of the United States of America
FGF1 patterns the optic vesicle by directing the placement of the neural retina domain.
Development (Cambridge, England)
Trabecular myocytes of the embryonic heart require N-cadherin for migratory unit identity.
Developmental biology
Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain.
The Journal of biological chemistry
Retroviral techniques for studying organogenesis with a focus on heart development.
Molecular and cellular biochemistry
Skeletal muscle-specific myosin binding protein-H is expressed in Purkinje fibers of the cardiac conduction system.
Circulation research
The use of replication-defective retroviruses for cell lineage studies of myogenic cells.
Methods in cell biology
Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo.
Journal of neurobiology
The fate diversity of mesodermal cells within the heart field during chicken early embryogenesis.
Developmental biology
Smooth muscle alpha-actin downregulation in cultured chick aortic smooth muscle and neural crest cells is associated with altered cell shape.
Experimental cell research
Retroviral vectors to study cardiovascular development.
Trends in cardiovascular medicine
Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ.
Developmental biology
Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle.
Development (Cambridge, England)
The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle.
Journal of cell science
The polyclonal origin of myocyte lineages.
Annual review of physiology
Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system.
Development (Cambridge, England)
An additional limb can be induced from the flank of the chick embryo by FGF4.
Biochemical and biophysical research communications
Retroviral targeting of FGF and FGFR in cardiomyocytes and coronary vascular cells during heart development.
Annals of the New York Academy of Sciences
Antisense suppression of skeletal muscle myosin light chain-1 biosynthesis impairs myofibrillogenesis in cultured myotubes.
Journal of muscle research and cell motility
FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions.
Developmental biology
Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.
Proceedings of the National Academy of Sciences of the United States of America
Mapping the origin of the avian enteric nervous system with a retroviral marker.
Developmental dynamics : an official publication of the American Association of Anatomists
The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif.
The Journal of cell biology
Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels.
Proceedings of the National Academy of Sciences of the United States of America
Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus. III: Polyclonal origin of adjacent ventricular myocytes.
Developmental dynamics : an official publication of the American Association of Anatomists
Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction.
Development (Cambridge, England)
Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus: I. Formation of the ventricular myocardium.
Developmental dynamics : an official publication of the American Association of Anatomists
In vivo analysis of a new lacZ retrovirus vector suitable for cell lineage marking in avian and other species.
Experimental cell research
Changes in myosin isozymes during development of chicken breast muscle.
Journal of biochemistry