
Professor
Cell and Tissue Biology
+1 415 514-0172
Michael McMaster, PhD research interests center on placental development, diseases of pregnancy and embryonic stem cell model systems for understanding the consequences of gestational exposures to environmental chemicals.
Publications
High rates of placental inflammation among samples collected by the Multi-Omics for Mothers and Infants consortium.
American journal of obstetrics and gynecology
Organophosphate and organohalogen flame retardant exposure and thyroid hormone disruption in women firefighters and office workers from San Francisco.
ISEE Conference Abstracts
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease.
Developmental cell
Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface.
Reproductive sciences (Thousand Oaks, Calif.)
Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya.
Journal of acquired immune deficiency syndromes (1999)
Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.
Proceedings of the National Academy of Sciences of the United States of America
Cover Image, Volume 36, Issue 9.
Prenatal diagnosis
Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects.
Prenatal diagnosis
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
Development (Cambridge, England)
Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia.
Journal of Clinical Investigation
Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia.
The Journal of clinical investigation
Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy.
Biology of reproduction
Human trophoblast progenitors: where do they reside?
Seminars in reproductive medicine
Establishment of human trophoblast progenitor cell lines from the chorion.
Stem cells (Dayton, Ohio)
Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood.
European journal of obstetrics, gynecology, and reproductive biology
GROa regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.
Differentiation; research in biological diversity
721: Global gene expression profiling of the maternal-fetal interface in common aneuploidies: identification of gene dosage-dependant phenotypes.
American journal of obstetrics and gynecology
613: Chromosomal abnormalities and the risk for preeclampsia/eclampsia.
American journal of obstetrics and gynecology
Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo.
Reproductive toxicology (Elmsford, N.Y.)
Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor.
Cell and tissue research
Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall.
Reproductive toxicology (Elmsford, N.Y.)
The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G.
Diabetes
Expression of HLA-G in malignant mesothelioma and clinically aggressive breast carcinoma.
Virchows Archiv : an international journal of pathology
Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders.
Fertility and sterility
HLA-G expression in effusions is a possible marker of tumor susceptibility to chemotherapy in ovarian carcinoma.
Gynecologic oncology
HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract.
International journal of gastrointestinal cancer
Abnormal placentation and the syndrome of preeclampsia.
Seminars in nephrology
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.
The Journal of clinical investigation
Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insufficiently provide HLA-E ligands.
Human immunology
Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C.
Developmental biology
HLA-G is a potential tumor marker in malignant ascites.
Clinical cancer research : an official journal of the American Association for Cancer Research
Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy.
Reproductive toxicology (Elmsford, N.Y.)
Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies.
American journal of obstetrics and gynecology
Placental Development.
Encyclopedia of Hormones
HLA-G immunoreactivity is specific for intermediate trophoblast in gestational trophoblastic disease and can serve as a useful marker in differential diagnosis.
The American journal of surgical pathology
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
The American journal of pathology
Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer.
The Journal of pathology
Histocompatibility leukocyte antigen-G is not expressed by endometriosis or endometrial tissue.
Fertility and sterility
Concordant in situ and in vitro data show that maternal cigarette smoking negatively regulates placental cytotrophoblast passage through the cell cycle.
Reproductive toxicology (Elmsford, N.Y.)
HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression.
Human immunology
A repertoire of cell cycle regulators whose expression is coordinated with human cytotrophoblast differentiation.
The American journal of pathology
HLA-G Does Not Mediate the Natural Killer Cell Suppression Associated with Endometriosis.
Fertility and sterility
Posttranscriptional regulation of human leukocyte antigen G during human extravillous cytotrophoblast differentiation.
Biology of reproduction
Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration.
Development (Cambridge, England)
Upregulation of human cytotrophoblast invasion by hepatocyte growth factor.
Journal of reproduction and fertility. Supplement
Invasive cytotrophoblast apoptosis in pre-eclampsia.
Human reproduction (Oxford, England)
Oxygen Regulates Human Cytotrophoblast Proliferation, Differentiation, and Invasion: Implications for Endovascular Invasion in Normal Pregnancy and Preeclampsia.
Embryo Implantation
HLA-G isoforms produced by placental cytotrophoblasts and found in amniotic fluid are due to unusual glycosylation.
Journal of immunology (Baltimore, Md. : 1950)
Complementary expression of HIP, a cell-surface heparan sulfate binding protein, and perlecan at the human fetal-maternal interface.
Biology of reproduction
Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia.
The American journal of pathology
Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts.
The Journal of experimental medicine
Tissue inhibitor of metalloproteinase-3 expression is upregulated during human cytotrophoblast invasion in vitro.
Developmental genetics
Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.
Journal of immunology (Baltimore, Md. : 1950)
Integrin switching regulates normal trophoblast invasion.
Development (Cambridge, England)
Human trophoblast invasion. Autocrine control and paracrine modulation.
Annals of the New York Academy of Sciences
Association of monocytes and neutrophils with early events of blastocyst implantation in mice.
Journal of reproduction and fertility
Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period.
Journal of immunology (Baltimore, Md. : 1950)
Lactoferrin in the mouse uterus: analyses of the preimplantation period and regulation by ovarian steroids.
Molecular endocrinology (Baltimore, Md.)
Metallothionein gene expression and metal regulation during preimplantation mouse embryo development (MT mRNA during early development).
Developmental biology
Endotoxin induction of murine metallothionein gene expression.
The Journal of biological chemistry
Cell type-specific expression of transforming growth factor-beta 1 in the mouse uterus during the periimplantation period.
Molecular endocrinology (Baltimore, Md.)
Cell-specific metallothionein gene expression in mouse decidua and placentae.
Development (Cambridge, England)