
Associate Professor
Pathology
+1 415 514-3062
Aras Mattis, MD, PhD, investigates the molecular mechanisms of human liver function and metabolic diseases like metabolic dysfunction-associated steatotic liver disease (MASLD). The Mattis lab develops human induced pluripotent stem cells that are then differentiated into multiple liver cell types including human hepatocyte-like cells (iPSC-derived hepatocytes) to develop models of this disease process. The laboratory is also interested in normal liver development.
Publications
MIR192 Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion.
bioRxiv : the preprint server for biology
AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion.
Nature biotechnology
Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells.
bioRxiv : the preprint server for biology
Fluoride-related changes in the fetal cord blood proteome; a pilot study.
Environmental health : a global access science source
Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas.
Gastroenterology
MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program.
International journal of molecular sciences
AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis.
Scientific reports
Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease.
Magnetic resonance in medicine
Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
bioRxiv : the preprint server for biology
Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.
PloS one
Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions.
Stem cells (Dayton, Ohio)
Fundic Gland Polyps Lack DNA Content Abnormality Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Transient expression of factor VIII and a chronic high-fat diet induces ER stress and late hepatocyte oncogenesis.
Molecular therapy : the journal of the American Society of Gene Therapy
Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis.
Frontiers in medicine
Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease.
Cellular and molecular gastroenterology and hepatology
Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A.
Nature medicine
Nonampullary Duodenal Adenomas in Familial Adenomatous Polyposis and Sporadic Patients Lack the DNA Content Abnormality That Is Characteristic of the Adenoma-Carcinoma Sequence Involved in the Development of Other Gastrointestinal Malignancies.
The American journal of surgical pathology
Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.
Hepatology (Baltimore, Md.)
Gastric Intestinal Metaplasia in Mucosa Adjacent to Gastric Cancers Is Rarely Associated With the Aneuploidy That Is Characteristic of Gastric Dysplasia or Cancer.
The American journal of surgical pathology
Persistent or recurrent Barrett's neoplasia after an endoscopic therapy session is associated with DNA content abnormality and can be detected by DNA flow cytometric analysis of paraffin-embedded tissue.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile.
Gastroenterology
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.
Cell death and differentiation
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Science translational medicine
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions.
Virchows Archiv : an international journal of pathology
DNA flow cytometric analysis of paraffin-embedded tissue for the diagnosis of malignancy in bile duct biopsies.
Human pathology
De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.
Journal of pediatric surgery
Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma.
JCI insight
Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Utility of DNA Flow Cytometric Analysis of Paraffin-embedded Tissue in the Risk Stratification and Management of 'Indefinite for dysplasia' in Patients With Inflammatory Bowel Disease.
Journal of Crohn's & colitis
Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment.
Blood advances
Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease.
Gastroenterology
Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver.
Journal of magnetic resonance imaging : JMRI
A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.
Journal of medicinal chemistry
Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
Journal of immunology (Baltimore, Md. : 1950)
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
Development (Cambridge, England)
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
Hepatology (Baltimore, Md.)
A ZFN/piggyBac step closer to autologous liver cell therapy.
Hepatology (Baltimore, Md.)
Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver.
Human pathology
Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics.
Arthritis care & research
Purification and characterization of bacteriophage P22 Xis protein.
Journal of bacteriology
IntDOT interactions with core- and arm-type sites of the conjugative transposon CTnDOT.
Journal of bacteriology
Integration host factor: putting a twist on protein-DNA recognition.
Journal of molecular biology
Increasing chromosome 1 copy number parallels histological progression in breast carcinogenesis.
British journal of cancer
20q13.2 amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast.
Virchows Archiv : an international journal of pathology