
Professor
Orthopaedic Surgery
+1 628 206-5366
Ralph Marcucio, PhD studies the molecular and cellular events that underlie skeletal development and regeneration.
Publications
Quantifying the relationship between cell proliferation and morphology during development of the face.
Development (Cambridge, England)
Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face.
bioRxiv : the preprint server for biology
PBX1 and PBX3 transcription factors regulate SHH expression in the Frontonasal Ectodermal Zone through complementary mechanisms.
bioRxiv : the preprint server for biology
Murine Progeria Model Exhibits Delayed Fracture Healing with Dysregulated Local Immune Response.
bioRxiv : the preprint server for biology
β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model.
Bioactive Materials
CD47 is Required for Mesenchymal Progenitor Proliferation and Fracture Repair.
bioRxiv : the preprint server for biology
Dosage-dependent effects of FGFR2W290R mutation on craniofacial shape and cellular dynamics of the basicranial synchondroses.
Anatomical record (Hoboken, N.J. : 2007)
Chapter 5 Macrophages in tissue engineering and regeneration.
Macrophages Biology and Tissue Inflammation in Health and Disease
Author Correction: MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.
Scientific data
The Developmental Basis for Evolvability.
Evolvability
Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair.
Frontiers in bioengineering and biotechnology
Quantifying the relationship between cell proliferation and morphology during development of the face.
bioRxiv : the preprint server for biology
Altered early immune response after fracture and traumatic brain injury.
Frontiers in immunology
A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair.
Journal of dental research
Segmentation of Tissues and Proliferating Cells in Light-Sheet Microscopy Images of Mouse Embryos Using Convolutional Neural Networks.
IEEE access : practical innovations, open solutions
Age-related decrease in periostin expression may be associated with attenuated fracture healing in old mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Cardiac alterations following experimental hip fracture - inflammaging as independent risk factor.
Frontiers in immunology
Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships.
Developmental dynamics : an official publication of the American Association of Anatomists
MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.
Scientific data
Developmental Morphospace of Embryonic Brain and Face Growth in the Chicken (Gallus gallus).
The FASEB Journal
Downstream Branches of the Fibroblast Growth Factor Signaling Pathway Act Interdependently to Shape the Face.
The FASEB Journal
Extracellular Matrix Composition Is Altered Alongside Dysmorphology in the Developing Palate.
The FASEB Journal
Integration of Cellular Dynamics and Morphology to Understand Mouse Facial Development.
The FASEB Journal
The Contribution of Macrophages in Old Mice to Periodontal Disease.
Journal of dental research
Wnt Signaling Drives Correlated Changes in Facial Morphology and Brain Shape.
Frontiers in cell and developmental biology
Systemic and local cardiac inflammation after experimental long bone fracture, traumatic brain injury and combined trauma in mice.
Journal of orthopaedic translation
Creating Avian Forebrain Chimeras to assess Facial Development.
Journal of visualized experiments : JoVE
Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion.
Scientific reports
Chondrocyte-to-osteoblast transformation in mandibular fracture repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural Crest Cells, and Craniofacial Abnormalities.
Frontiers in cell and developmental biology
miR-199 family contributes to regulation of sonic hedgehog expression during craniofacial development.
Developmental dynamics : an official publication of the American Association of Anatomists
A Registration and Deep Learning Approach to Automated Landmark Detection for Geometric Morphometrics.
Evolutionary biology
Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.
British journal of anaesthesia
A novel mouse model to study fracture healing of the proximal femur.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Mapping the relationship between proliferation and morphology in the developing mouse face.
The FASEB Journal
Regulatory Dynamics of Midfacial Growth in Evolution and Disease.
The FASEB Journal
AGE-RELATED CHANGES TO MACROPHAGES AFFECT FRACTURE HEALING.
Innovation in Aging
Integration and the Developmental Genetics of Allometry.
Integrative and comparative biology
Nonlinear gene expression-phenotype relationships contribute to variation and clefting in the A/WySn mouse.
Developmental dynamics : an official publication of the American Association of Anatomists
Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.
Scientific reports
Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling.
Proceedings of the National Academy of Sciences of the United States of America
Emergent Properties of Facial Morphogenesis Regulated by Fgf Signaling.
The FASEB Journal
Integration and the genetics of variation in facial shape.
The FASEB Journal
Modeling the Development of Cleft Lip and Palate in Variable Clefting Mouse Strains.
The FASEB Journal
The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting.
American journal of medical genetics. Part A
Cellular biology of fracture healing.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The developmental-genetics of canalization.
Seminars in cell & developmental biology
Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering.
Frontiers in bioengineering and biotechnology
The Society for Craniofacial Genetics and Developmental Biology 40th annual meeting.
American journal of medical genetics. Part A
Quantifying the Genotype to Phenotype Map in Developing Mice.
The FASEB Journal
Understanding the development of variable craniofacial phenotypes caused by altered methylation affecting Wnt9b in A-strain mice.
The FASEB Journal
Untangling Sources of Phenotypic Variation Characterizing the Craniofacial Disease Holoprosencephaly.
The FASEB Journal
Simulation enabled search for explanatory mechanisms of the fracture healing process.
PLoS computational biology
Living tissues are more than cell clusters: The extracellular matrix as a driving force in morphogenesis.
Progress in biophysics and molecular biology
Developmental nonlinearity drives phenotypic robustness.
Nature communications
Effects of Aging on Fracture Healing.
Current osteoporosis reports
Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing?
Frontiers in cell and developmental biology
Craniofacial diversification in the domestic pigeon and the evolution of the avian skull.
Nature ecology & evolution
Quantifying three-dimensional morphology and RNA from individual embryos.
Developmental dynamics : an official publication of the American Association of Anatomists
The society for craniofacial genetics and developmental biology 39th annual meeting.
American journal of medical genetics. Part A
Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses.
Journal of experimental zoology. Part B, Molecular and developmental evolution
Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes.
Development (Cambridge, England)
Future Treatment Strategies for Delayed Bone Healing: An Osteoimmunologic Approach.
The Journal of the American Academy of Orthopaedic Surgeons
FGFR-associated craniosynostosis syndromes and gastrointestinal defects.
American journal of medical genetics. Part A
Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel.
Journal of evolutionary biology
The society for craniofacial genetics and developmental biology 38th annual meeting.
American journal of medical genetics. Part A
60 Minutes of Tension: The Hour Long Research Talk.
The FASEB Journal
Evolvability and the Diversification of the Craniofacial Skeleton in the Domesticated Pigeon ( Columba livia ).
The FASEB Journal
Facial surface morphology predicts variation in internal skeletal shape.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
Matrix Reloaded: Devitalized Cartilage as a Functional Extracellular Niche to Promote Osteogenesis and Angiogenesis.
The FASEB Journal
Trans differentiation of Chondrocytes to Osteoblasts during Endochondral Ossification in the Healing Mandible.
The FASEB Journal
Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes.
Tissue engineering. Part A
Beyond cell proliferation in avian facial morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists
Stem Cell Therapies in Orthopaedic Trauma.
Journal of orthopaedic trauma
Morphometrics, 3D Imaging, and Craniofacial Development.
Current topics in developmental biology
Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and the Face.
Current topics in developmental biology
Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross.
Journal of anatomy
Correlations Between the Morphology of Sonic Hedgehog Expression Domains and Embryonic Craniofacial Shape.
Evolutionary biology
Signals from the brain induce variation in avian facial shape.
Developmental dynamics : an official publication of the American Association of Anatomists
Divergence of craniofacial developmental trajectories among avian embryos.
Developmental dynamics : an official publication of the American Association of Anatomists
Role of muscle stem cells during skeletal regeneration.
Stem cells (Dayton, Ohio)
Facial development and alterations in FGF signaling in a mouse model of Crouzon Syndrome.
The FASEB Journal
Mechanisms of FGF-Mediated Morphogenesis.
The FASEB Journal
The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells.
Acta biomaterialia
A comparative examination of odontogenic gene expression in both toothed and toothless amniotes.
Journal of experimental zoology. Part B, Molecular and developmental evolution
The multifaceted role of the vasculature in endochondral fracture repair.
Frontiers in endocrinology
A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face.
Development (Cambridge, England)
Content Experts.
Larsen's Human Embryology
Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice.
Disease models & mechanisms
Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage.
Disease models & mechanisms
Let's face it--complex traits are just not that simple.
PLoS genetics
Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans.
Wiley interdisciplinary reviews. Developmental biology
Surface landmark quantification of embryonic mouse craniofacial morphogenesis.
BMC developmental biology
A comparative examination of odontogenic markers in both toothed and toothless amniotes (344.3).
The FASEB Journal
Endochondral bone tissue engineering: using cartilage to drive vascularized bone regeneration (87.6).
The FASEB Journal
Therapeutic delivery of placental stem cells to modulate vasculature and promote fracture repair (342.6).
The FASEB Journal
Transdifferentiation of hypertrophic chondrocytes during endochondral bone repair by activation of pluripotent stem cell programs (216.1).
The FASEB Journal
Embryonic bauplans and the developmental origins of facial diversity and constraint.
Development (Cambridge, England)
Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
9 Cartilage grafts for bone repair and regeneration.
Bone Substitute Biomaterials
Contributor contact details.
Bone Substitute Biomaterials
Modulation of macrophage activity during fracture repair has differential effects in young adult and elderly mice.
Journal of orthopaedic trauma
Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Selective estrogen receptor modulation prevents scoliotic curve progression: radiologic and histomorphometric study on a bipedal C57Bl6 mice model.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis.
Human molecular genetics
The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos.
Disease models & mechanisms
Embryonic origins of novelty and constraint in the amniote upper jaw.
The FASEB Journal
Disruption of thrombospondin-2 accelerates ischemic fracture healing.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.
Developmental biology
The generation of variation and the developmental basis for evolutionary novelty.
Journal of experimental zoology. Part B, Molecular and developmental evolution
Anti-inflammatory treatment increases angiogenesis during early fracture healing.
Archives of orthopaedic and trauma surgery
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects.
Journal of Visualized Experiments
Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects.
Journal of visualized experiments : JoVE
A Novel Gene Crispld2 may Contribute to Facial Dysmophology in a Chicken Model of Crouzon's Syndrome.
The FASEB Journal
Modulation of Shh signaling by microRNAs.
The FASEB Journal
Neural crest cells pattern the surface cephalic ectoderm during FEZ formation.
Developmental dynamics : an official publication of the American Association of Anatomists
The Phenogenomics of Craniofacial Shape.
The FASEB Journal
Tissue Interactions that Regulate Facial Morphogenesis.
The FASEB Journal
Tissue engineering bone by recapitulating developmental and repair programs offers improved biological outcomes.
The FASEB Journal
The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Signaling by SHH rescues facial defects following blockade in the brain.
Developmental dynamics : an official publication of the American Association of Anatomists
Vascular endothelial growth factor improves bone repair in a murine nonunion model.
The Iowa orthopaedic journal
Epigenetic integration of the developing brain and face.
Developmental Dynamics
Epigenetic integration of the developing brain and face.
Developmental dynamics : an official publication of the American Association of Anatomists
Mechanical stability affects angiogenesis during early fracture healing.
Journal of orthopaedic trauma
Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy.
Osteoarthritis and Cartilage
Effects of Bone Morphogenetic Proteins on TGF-beta, Wnt and BMP Pathways During Tibial Fracture Repair.
The FASEB Journal
Identification and Validation of Gene Expression Profile in Facial Dysmorphology of Craniosynostosis Crouzon Syndrome.
The FASEB Journal
The cellular basis of hypoxia induced craniofacial malformations.
The FASEB Journal
Assessing Signaling Properties of Ectodermal Epithelia During Craniofacial Development.
Journal of Visualized Experiments
Assessing signaling properties of ectodermal epithelia during craniofacial development.
Journal of visualized experiments : JoVE
Mechanisms that underlie co-variation of the brain and face.
Genesis (New York, N.Y. : 2000)
Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2.
Disease models & mechanisms
Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape.
Development (Cambridge, England)
Trauma-induced inflammation and fracture healing.
Journal of orthopaedic trauma
Rejuvenation of the inflammatory system stimulates fracture repair in aged mice.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Action of IL-1beta during fracture healing.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Recombinant human bone morphogenetic protein-7 enhances fracture healing in an ischemic environment.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
A craniosynostosis-syndrome related Fgfr2 mutation promotes early craniofacial defects in chick.
The FASEB Journal
Multiple roles for CCR2 during fracture healing.
Disease models & mechanisms
Absence of beta3 integrin accelerates early skeletal repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Deciphering the Palimpsest: Studying the Relationship Between Morphological Integration and Phenotypic Covariation.
Evolutionary biology
Basic research in orthopedic surgery: Current trends and future directions.
Indian journal of orthopaedics
Hypoxia as an Environmental Cause of Holoprosencephaly.
The FASEB Journal
The effect of early Bone Morphogenetic Protein (BMP) activation on craniofacial development.
The FASEB Journal
The relationship between variable SHH signaling and the severity of structural defects in the face and brain.
The FASEB Journal
The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model.
Spine
The effect of calmodulin antagonists on scoliosis: bipedal C57BL/6 mice model.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Effect of bone morphogenetic protein signaling on development of the jaw skeleton.
Developmental dynamics : an official publication of the American Association of Anatomists
A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm.
Development (Cambridge, England)
Unique organization of the frontonasal ectodermal zone in birds and mammals.
Developmental biology
Effect of age on vascularization during fracture repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Epithelial-Mesenchymal Interactions during Facial Development in Mice.
The FASEB Journal
Tibial fracture decreases oxygen levels at the site of injury.
The Iowa orthopaedic journal
Effects of delayed stabilization on fracture healing.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Signaling by bone morphogenetic proteins directs formation of an ectodermal signaling center that regulates craniofacial development.
Developmental biology
Bone morphogenetic proteins (BMPs) direct formation of a signaling center that regulates facial development.
Developmental biology
Ischemia leads to delayed union during fracture healing: a mouse model.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Assessing angiogenesis during fracture healing.
The Iowa orthopaedic journal
Cellular basis for age-related changes in fracture repair.
Journal of Orthopaedic Research®
Molecular interactions coordinating the development of the forebrain and face.
Developmental biology
Cellular basis for age-related changes in fracture repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The Collaborative Cross, a community resource for the genetic analysis of complex traits.
Nature genetics
Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes.
The Journal of clinical investigation
Morphogenesis of blood vessels in the head muscles of avian embryo: spatial, temporal, and VEGF expression analyses.
Developmental dynamics : an official publication of the American Association of Anatomists
A zone of frontonasal ectoderm regulates patterning and growth in the face.
Development (Cambridge, England)
Prenatal morphogenesis of the human mental foramen.
European journal of oral sciences
Differentiation of avian craniofacial muscles: I. Patterns of early regulatory gene expression and myosin heavy chain synthesis.
Developmental dynamics : an official publication of the American Association of Anatomists
Myotube heterogeneity in developing chick craniofacial skeletal muscles.
Developmental dynamics : an official publication of the American Association of Anatomists
In vitro interaction between oviduct epithelial and equine sperm.
Archives of andrology