
Professor
Ob/Gyn, Reproductive Sciences
+1 415 476-5471
Diana Laird, PhD studies the development and regulation of primordial germ cells, stem cells in the embryo that give rise to eggs or sperm.
Publications
Ancient viruses sustain mammalian reproduction.
Nature aging
Mammalian oocytes receive maternal-effect RNAs from granulosa cells.
bioRxiv : the preprint server for biology
Defining the cell and molecular origins of the primate ovarian reserve.
bioRxiv : the preprint server for biology
An updated reference genome sequence and annotation reveals gene losses and gains underlying naked mole-rat biology.
bioRxiv : the preprint server for biology
Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants.
bioRxiv : the preprint server for biology
Sustained fertility from first-wave follicle oocytes that pause their growth.
bioRxiv : the preprint server for biology
Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.
Molecular therapy. Methods & clinical development
Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions.
Developmental cell
Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
eLife
Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
eLife
Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling.
bioRxiv : the preprint server for biology
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.
Nature structural & molecular biology
Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.
bioRxiv : the preprint server for biology
Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats.
Nature communications
TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated Regions.
bioRxiv : the preprint server for biology
A Roadmap for Three-Dimensional Analysis of the Intact Mouse Ovary.
Methods in molecular biology (Clifton, N.J.)
Ovary Development: Insights From a Three-Dimensional Imaging Revolution.
Frontiers in cell and developmental biology
Natural selection at the cellular level: insights from male germ cell differentiation.
Cell death and differentiation
Intercellular bridges coordinate the transition from pluripotency to meiosis in mouse fetal oocytes.
Science advances
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones.
Nature cell biology
MON-LB130 Glucocorticoid Receptor Signaling and Stress in the Developing Mammalian Germline.
Journal of the Endocrine Society
The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.
G3 (Bethesda, Md.)
Heterogeneity of primordial germ cells.
Current topics in developmental biology
Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells.
Development (Cambridge, England)
A pilgrim's progress: Seeking meaning in primordial germ cell migration.
Stem cell research
Patterning of sharp cellular interfaces with a reconfigurable elastic substrate.
Integrative biology : quantitative biosciences from nano to macro
Insights from imaging the implanting embryo and the uterine environment in three dimensions.
Development (Cambridge, England)
ROR2 in the adult mouse testis.
Molecular reproduction and development
Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling.
The Journal of cell biology
Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary.
Journal of cell science
A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.
Stem cells (Dayton, Ohio)
DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
Journal of cell science
Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity.
Fertility and sterility
Follicle dynamics and global organization in the intact mouse ovary.
Developmental biology
Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system.
Developmental dynamics : an official publication of the American Association of Anatomists
Wnt and Bmp fit germ cells to a T.
Developmental cell
Humans put their eggs in more than one basket.
Nature cell biology
Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.
Human molecular genetics
miR-372/let-7 axis regulates human primordial germ cell specification.
Fertility and sterility
Lin28-let7-Blimp1 Circuitry regulates human primordial germ cells (hPGC) development from human embryonic stem cells (hESC).
Fertility and sterility
Establishment and characterization of human germ cells derived from embryonic stem cells (hESCs).
Fertility and sterility
Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.
The Journal of clinical investigation
Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri.
Developmental dynamics : an official publication of the American Association of Anatomists
Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri.
Developmental biology
Continuous development precludes radioprotection in a colonial ascidian.
Developmental and comparative immunology
50 million years of chordate evolution: seeking the origins of adaptive immunity.
Proceedings of the National Academy of Sciences of the United States of America