 
Professor
      
      Pathology
          +1 415 514-3130
      Matthew Krummel, PhD uses in situ imaging of proximal molecular events in the thymus to determine how signaling proceeds in the context of tissues and organs.
Publications
The coming era of nudge drugs for cancer.
Cancer cell
      
            
      
      Localized in vivo gene editing of murine cancer-associated fibroblasts.
bioRxiv : the preprint server for biology
      
            
      
      Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors.
Science immunology
      
            
      
      Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality.
medRxiv : the preprint server for health sciences
      
            
      
      Tumor cell heterogeneity drives spatial organization of the intratumoral immune response.
The Journal of experimental medicine
      
            
      
      Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.
medRxiv : the preprint server for health sciences
      
            
      
      Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer.
The Journal of experimental medicine
      
            
      
      Multimodal identification of rare potent effector CD8 T cells in solid tumors.
bioRxiv : the preprint server for biology
      
            
      
      Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis.
The Journal of experimental medicine
      
            
      
      Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia.
Nature communications
      
            
      
      Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer.
bioRxiv : the preprint server for biology
      
            
      
      Immediate myeloid depot for SARS-CoV-2 in the human lung.
Science advances
      
            
      
      Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Nature communications
      
            
      
      Critical role of CD206+ macrophages in organizing anti-tumor immunity.
bioRxiv : the preprint server for biology
      
            
      
      Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data.
Frontiers in immunology
      
            
      
      TREM1 activation of myeloid cells promotes antitumor immunity.
Science translational medicine
      
            
      
      Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma.
bioRxiv : the preprint server for biology
      
            
      
      Defining and using immune archetypes to classify and treat cancer.
Nature reviews. Cancer
      
            
      
      Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer.
Cell stem cell
      
            
      
      Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.
Cell reports
      
            
      
      Polyunsaturated Fatty Acid-Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism.
Cancer research
      
            
      
      High-dimensional immune cell profiling of cerebrospinal fluid from patients with metastatic breast cancer and leptomeningeal disease.
NPJ breast cancer
      
            
      
      Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
The Journal of clinical investigation
      
            
      
      Cyclone: an accessible pipeline to analyze, evaluate and optimize multiparametric cytometry data.
bioRxiv : the preprint server for biology
      
            
      
      SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
Stem cell reports
      
            
      
      Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors.
The Journal of cell biology
      
            
      
      COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
American journal of respiratory and critical care medicine
      
            
      
      Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells.
Nature communications
      
            
      
      T cells use distinct topographical and membrane receptor scanning strategies that individually coalesce during receptor recognition.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Immunity
      
            
      
      Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy.
Cancer immunology research
      
            
      
      Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer.
Cell reports
      
            
      
      Immediate myeloid depot for SARS-CoV-2 in the human lung.
Research square
      
            
      
      Immediate myeloid depot for SARS-CoV-2 in the human lung.
bioRxiv : the preprint server for biology
      
            
      
      Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.
Cancer immunology research
      
            
      
      A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
bioRxiv : the preprint server for biology
      
            
      
      Genetic and immunologic features of recurrent stage I lung adenocarcinoma.
Scientific reports
      
            
      
      Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
medRxiv : the preprint server for health sciences
      
            
      
      Archetypes of checkpoint-responsive immunity.
Trends in immunology
      
            
      
      Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK Blockade, and CD40 Agonism.
Gastroenterology
      
            
      
      Active surveillance characterizes human intratumoral T cell exhaustion.
The Journal of clinical investigation
      
            
      
      Layilin Anchors Regulatory T Cells in Skin.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Nature communications
      
            
      
      Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
Science translational medicine
      
            
      
      Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
Nature
      
            
      
      The WAVE complex associates with sites of saddle membrane curvature.
The Journal of cell biology
      
            
      
      SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
bioRxiv : the preprint server for biology
      
            
      
      DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells.
Journal for immunotherapy of cancer
      
            
      
      Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Research square
      
            
      
      A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.
Science immunology
      
            
      
      Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging.
Nature communications
      
            
      
      Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19.
bioRxiv : the preprint server for biology
      
            
      
      COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Research square
      
            
      
      Visualizing Cancer.
Cancer cell
      
            
      
      SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution.
Cell metabolism
      
            
      
      Global Absence and Targeting of Protective Immune States in Severe COVID-19.
bioRxiv : the preprint server for biology
      
            
      
      Lessons of COVID-19: A roadmap for post-pandemic science.
The Journal of experimental medicine
      
            
      
      The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies.
Nature immunology
      
            
      
      Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma.
Annals of surgical oncology
      
            
      
      Carpet-bombing tumors with IFN-γ.
Nature cancer
      
            
      
      Spacer-Mediated Control of Coumarin Uncaging for Photocaged Thymidine.
The Journal of organic chemistry
      
            
      
      mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
Science advances
      
            
      
      Dendritic cells in cancer immunology and immunotherapy.
Nature reviews. Immunology
      
            
      
      Tuning the Tumor Myeloid Microenvironment to Fight Cancer.
Frontiers in immunology
      
            
      
      Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans.
Science immunology
      
            
      
      Immunity as a continuum of archetypes.
Science (New York, N.Y.)
      
            
      
      α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.
Journal for immunotherapy of cancer
      
            
      
      Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.
Mucosal immunology
      
            
      
      A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
Nature medicine
      
            
      
      Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4+ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin.
Cancer immunology research
      
            
      
      Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.
The American journal of pathology
      
            
      
      TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer.
Cancer cell
      
            
      
      Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy.
JCI insight
      
            
      
      Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.
Science (New York, N.Y.)
      
            
      
      The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.
Science immunology
      
            
      
      Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.
Cancer immunology research
      
            
      
      Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer.
ACS chemical biology
      
            
      
      Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
      
            
      
      CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.
The Journal of experimental medicine
      
            
      
      Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy.
Nature methods
      
            
      
      CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity.
Cancer research
      
            
      
      Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.
The Journal of clinical investigation
      
            
      
      T cell migration, search strategies and mechanisms.
Nature reviews. Immunology
      
            
      
      STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis.
Cancer research
      
            
      
      A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
Nature immunology
      
            
      
      Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
      
            
      
      TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      The emerging understanding of myeloid cells as partners and targets in tumor rejection.
Cancer immunology research
      
            
      
      Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.
PloS one
      
            
      
      A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      The subtle hands of self-reactivity in peripheral T cells.
Nature immunology
      
            
      
      Antigen recognition in the islets changes with progression of autoimmune islet infiltration.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
Cell stem cell
      
            
      
      The spatiotemporal cellular dynamics of lung immunity.
Trends in immunology
      
            
      
      An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA.
Current opinion in cell biology
      
            
      
      Leukotriene B4 amplifies eosinophil accumulation in response to nematodes.
The Journal of experimental medicine
      
            
      
      Assessing and benchmarking multiphoton microscopes for biologists.
Methods in cell biology
      
            
      
      Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm.
Immunological reviews
      
            
      
      Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
Nature immunology
      
            
      
      Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E.
Immunity
      
            
      
      Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses.
Immunological reviews
      
            
      
      Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Integration of the movement of signaling microclusters with cellular motility in immunological synapses.
Nature immunology
      
            
      
      Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
The Journal of experimental medicine
      
            
      
      Live imaging of the lung.
Current protocols in cytometry
      
            
      
      The septin cytoskeleton facilitates membrane retraction during motility and blebbing.
The Journal of cell biology
      
            
      
      Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. The journal of experimental medicine. 1995. 182: 459-465.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Stabilized imaging of immune surveillance in the mouse lung.
Nature methods
      
            
      
      Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics.
The Journal of experimental medicine
      
            
      
      Duration of antigen receptor signaling determines T-cell tolerance or activation.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions.
Nature immunology
      
            
      
      Mediation of T-cell activation by actin meshworks.
Cold Spring Harbor perspectives in biology
      
            
      
      Control of cortical rigidity by the cytoskeleton: emerging roles for septins.
Cytoskeleton (Hoboken, N.J.)
      
            
      
      The immunological synapse: a dynamic platform for local signaling.
Journal of clinical immunology
      
            
      
      Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions.
Current topics in microbiology and immunology
      
            
      
      Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
Nature immunology
      
            
      
      Matthew Krummel: visions enumerated. Interview by Amy Maxmen.
The Journal of experimental medicine
      
            
      
      Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses.
Current topics in microbiology and immunology
      
            
      
      Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility.
Nature cell biology
      
            
      
      Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.
Disease models & mechanisms
      
            
      
      Deletional tolerance mediated by extrathymic Aire-expressing cells.
Science (New York, N.Y.)
      
            
      
      Distinct functions for HS1 in chemosensory versus adhesive signaling.
Nature immunology
      
            
      
      A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction.
Immunity
      
            
      
      Testing the organization of the immunological synapse.
Current opinion in immunology
      
            
      
      Maintenance and modulation of T cell polarity.
Nature immunology
      
            
      
      Imaging the function of regulatory T cells in vivo.
Current opinion in immunology
      
            
      
      Triggering of T cell activation via CD4 dimers.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Nature immunology
      
            
      
      Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants.
Seminars in immunology
      
            
      
      Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.
PLoS biology
      
            
      
      T cell synapse assembly: proteins, motors and the underlying cell biology.
Seminars in immunology
      
            
      
      Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      New views of the immunological synapse: variations in assembly and function.
Current opinion in immunology
      
            
      
      CD28 signals in the immature immunological synapse.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      A single class II myosin modulates T cell motility and stopping, but not synapse formation.
Nature immunology
      
            
      
      Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Dynamics of the immunological synapse: finding, establishing and solidifying a connection.
Current opinion in immunology
      
            
      
      Thirty-six views of T-cell recognition.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
      
            
      
      Differential clustering of CD4 and CD3zeta during T cell recognition.
Science (New York, N.Y.)
      
            
      
      Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7.
Journal of immunology (Baltimore, Md. : 1950)
      
            
      
      Visualizing T-cell recognition.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      The threshold for autoimmune T cell killing is influenced by B7-1.
European journal of immunology
      
            
      
      A role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance?
Novartis Foundation symposium
      
            
      
      The nature of the signals regulating CD8 T cell proliferative responses to CD8alpha+ or CD8alpha- dendritic cells.
European journal of immunology
      
            
      
      Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis.
Journal of neuroimmunology
      
            
      
      The role of CTLA-4 in the regulation and initiation of T-cell responses.
Immunological reviews
      
            
      
      CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.
The Journal of experimental medicine
      
            
      
      Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo.
International immunology
      
            
      
      Enhancement of antitumor immunity by CTLA-4 blockade.
Science (New York, N.Y.)
      
            
      
      The Yin and Yang of T cell costimulation.
Science (New York, N.Y.)
      
            
      
      CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
The Journal of experimental medicine
      
            
      
      