
Professor
Cell and Tissue Biology
+1 415 502-0811
Sarah Knox, PhD studies the role of neuronal-epithelial interactions during organogenesis and regeneration.
Publications
Chronic degenerative failure of salivary glands can be reversed through restoring mitochondrial function.
bioRxiv : the preprint server for biology
Rebuilding the autoimmune-damaged corneal stroma through topical lubrication.
bioRxiv : the preprint server for biology
Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel.
Science advances
Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling.
Developmental cell
A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration.
Cell reports
A mechanism of gene evolution generating mucin function.
Science advances
Exocrine gland structure-function relationships.
Development (Cambridge, England)
Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis.
International forum of allergy & rhinology
Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva.
Cell reports
Alterations in corneal biomechanics underlie early stages of autoimmune-mediated dry eye disease.
Journal of autoimmunity
The emerging role of cranial nerves in shaping craniofacial development.
Genesis (New York, N.Y. : 2000)
Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome.
International journal of molecular sciences
Diverse progenitor cells preserve salivary gland ductal architecture after radiation-induced damage.
Development (Cambridge, England)
Lineage dynamics of murine pancreatic development at single-cell resolution.
Nature communications
Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
Proceedings of the National Academy of Sciences of the United States of America
Salivary gland stem cells: A review of development, regeneration and cancer.
Genesis (New York, N.Y. : 2000)
Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement.
EMBO molecular medicine
Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome.
PloS one
Identification and characterization of a rich population of CD34+ mesenchymal stem/stromal cells in human parotid, sublingual and submandibular glands.
Scientific reports
Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.
Development (Cambridge, England)
miR-205 is a critical regulator of lacrimal gland development.
Developmental biology
Salivary gland development and disease.
Wiley interdisciplinary reviews. Developmental biology
Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors.
Developmental cell
Manipulating the Murine Lacrimal Gland.
Journal of Visualized Experiments
Manipulating the murine lacrimal gland.
Journal of visualized experiments : JoVE
Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
Developmental cell
The society of craniofacial genetics and developmental biology 35th annual meeting.
American Journal of Medical Genetics Part A
Parasympathetic stimulation improves epithelial organ regeneration.
Nature communications
Salivary gland organogenesis.
Wiley interdisciplinary reviews. Developmental biology
Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration.
Oral diseases
Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis.
Science (New York, N.Y.)
Recombinant heparan sulfate for use in tissue engineering applications.
Journal of Chemical Technology & Biotechnology
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
Development (Cambridge, England)