
Professor
M_Physiology
+1 415 476-8747
Yuh Nung Jan, PhD identifies genes involved in maintaining adult neural stem cells in mice with the intent of defining their precise functions. With this knowledge, he hopes to develop therapies for neurological disorders, such as Parkinson’s disease.
Publications
Experimental tools and emerging principles of organellar mechanotransduction.
Trends in cell biology
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families.
Nature structural & molecular biology
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
Communications biology
TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.
Proceedings of the National Academy of Sciences of the United States of America
Nonlinear compliance of NompC gating spring and its implication in mechanotransduction.
bioRxiv : the preprint server for biology
Molecular recording of calcium signals via calcium-dependent proximity labeling.
Nature chemical biology
A personal perspective of the voltage-gated potassium channel studies.
Nature structural & molecular biology
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.
Nature cell biology
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nature communications
A new cell in an old tactile sensory organ.
Nature cell biology
SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
bioRxiv : the preprint server for biology
The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling.
The Journal of cell biology
A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America
Kv1.1 preserves the neural stem cell pool and facilitates neuron maturation during adult hippocampal neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
Science (New York, N.Y.)
TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
Proceedings of the National Academy of Sciences of the United States of America
Interorganelle communication, aging, and neurodegeneration.
Genes & development
TMEM16K is an interorganelle regulator of endosomal sorting.
Nature communications
Mechanisms of neurite repair.
Current opinion in neurobiology
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms.
Annual review of neuroscience
The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration.
Genes & development
Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.
Genes & development
Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell reports
Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity.
eLife
TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell reports
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.
Proceedings of the National Academy of Sciences of the United States of America
JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites.
Development (Cambridge, England)
Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.
Proceedings of the National Academy of Sciences of the United States of America
Chemically induced vesiculation as a platform for studying TMEM16F activity.
Proceedings of the National Academy of Sciences of the United States of America
Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.
Proceedings of the National Academy of Sciences of the United States of America
Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics.
The Journal of general physiology
Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.
Genes & development
Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.
Proceedings of the National Academy of Sciences of the United States of America
Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.
Cell reports
Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.
Cell reports
Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.
Cell reports
A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.
The Journal of physiology
In vivo dendrite regeneration after injury is different from dendrite development.
Genes & development
Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.
Proceedings of the National Academy of Sciences of the United States of America
Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo.
Protein science : a publication of the Protein Society
Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons.
PLoS genetics
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Nature neuroscience
Regulation of axon regeneration by the RNA repair and splicing pathway.
Nature neuroscience
Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.
Proceedings of the National Academy of Sciences of the United States of America
Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.
Genes & development
An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.
Nature communications
Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.
Proceedings of the National Academy of Sciences of the United States of America
Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila.
Nature neuroscience
Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae.
Proceedings of the National Academy of Sciences of the United States of America
TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
Nature neuroscience
Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).
Proceedings of the National Academy of Sciences of the United States of America
Increased neuronal activity fragments the Golgi complex.
Proceedings of the National Academy of Sciences of the United States of America
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Proceedings of the National Academy of Sciences of the United States of America
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Genes & development
Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Genes & development
Contribution of visual and circadian neural circuits to memory for prolonged mating induced by rivals.
Nature neuroscience
Voltage-gated potassium channels and the diversity of electrical signalling.
The Journal of physiology
Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers.
The Journal of physiology
Yoshiki Hotta's influence.
Journal of neurogenetics
Activity of the mitochondrial calcium uniporter varies greatly between tissues.
Nature communications
Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.
Proceedings of the National Academy of Sciences of the United States of America
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.
Journal of molecular medicine (Berlin, Germany)
Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Light-induced structural and functional plasticity in Drosophila larval visual system.
Science (New York, N.Y.)
Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.
Development (Cambridge, England)
Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Differential regulation of dendritic and axonal development by the novel Kr�ppel-like factor Dar1.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.
Development (Cambridge, England)
Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism.
Proceedings of the National Academy of Sciences of the United States of America
Branching out: mechanisms of dendritic arborization.
Nature reviews. Neuroscience
Studies on expression and function of the TMEM16A calcium-activated chloride channel.
Proceedings of the National Academy of Sciences of the United States of America
Patterning and organization of motor neuron dendrites in the Drosophila larva.
Developmental biology
Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis.
Proceedings of the National Academy of Sciences of the United States of America
Control of the postmating behavioral switch in Drosophila females by internal sensory neurons.
Neuron
G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.
Proceedings of the National Academy of Sciences of the United States of America
Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels.
Proceedings of the National Academy of Sciences of the United States of America
Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.
Proceedings of the National Academy of Sciences of the United States of America
The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.
Genes & development
Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons.
Nature cell biology
Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.
Genes & development
Drosophila egg-laying site selection as a system to study simple decision-making processes.
Science (New York, N.Y.)
Retrospective: Seymour Benzer (1921-2007).
Science (New York, N.Y.)
Identification of yeast proteins necessary for cell-surface function of a potassium channel.
Proceedings of the National Academy of Sciences of the United States of America
Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.
Nature neuroscience
Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites.
Genes & development
Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae.
Proceedings of the National Academy of Sciences of the United States of America
Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields.
Annual review of neuroscience
Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology.
Development (Cambridge, England)
SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes.
Proceedings of the National Academy of Sciences of the United States of America
The secretory pathway and neuron polarization.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites.
Science (New York, N.Y.)
The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons.
Genes & development
Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.
Proceedings of the National Academy of Sciences of the United States of America
K+ channel selectivity depends on kinetic as well as thermodynamic factors.
Proceedings of the National Academy of Sciences of the United States of America
Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains.
Proceedings of the National Academy of Sciences of the United States of America
The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila.
Current biology : CB
Visualizing the breaking of symmetry.
Developmental cell
Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites.
Genes & development
Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.
Proceedings of the National Academy of Sciences of the United States of America
Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling.
Proceedings of the National Academy of Sciences of the United States of America
The development of neuronal morphology in insects.
Current biology : CB
The hand that rocks the spindle.
Nature cell biology
The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.
Neuron
Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases.
Molecular biology of the cell
Mammalian electrophysiology on a microfluidic platform.
Proceedings of the National Academy of Sciences of the United States of America
Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs.
Molecular biology of the cell
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.
Development (Cambridge, England)
Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America
The cadherin superfamily and dendrite development.
Trends in cell biology
A fluorescent probe designed for studying protein conformational change.
Proceedings of the National Academy of Sciences of the United States of America
The Notch regulator Numb links the Notch and TCR signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.
Genes & development
A quantitative assessment of models for voltage-dependent gating of ion channels.
Proceedings of the National Academy of Sciences of the United States of America
The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development.
Molecular biology of the cell
APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.
Current biology : CB
Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1).
Proceedings of the National Academy of Sciences of the United States of America
The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation.
Proceedings of the National Academy of Sciences of the United States of America
NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.
Proceedings of the National Academy of Sciences of the United States of America
Asymmetric cell division.
Current opinion in cell biology
Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity.
Proceedings of the National Academy of Sciences of the United States of America
Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification.
Genes & development
Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.
Current biology : CB
Dendritic development: lessons from Drosophila and related branches.
Current opinion in neurobiology
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging.
Nature genetics
Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture.
Proceedings of the National Academy of Sciences of the United States of America
Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes.
Evolution & development
A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels.
Science (New York, N.Y.)
Yuh-Nung Jan.
Current biology : CB
Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia.
Development (Cambridge, England)
Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage.
Current biology : CB
Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion.
Current biology : CB
A lethal giant kinase in cell polarity.
Nature cell biology
The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.
Developmental cell
Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.
Cell
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.
Development (Cambridge, England)
Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.
Current biology : CB
salvador--The persistence of proliferation.
Cancer cell
hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology.
Science (New York, N.Y.)
Tiling of the Drosophila epidermis by multidendritic sensory neurons.
Development (Cambridge, England)
Probing protein electrostatics with a synthetic fluorescent amino acid.
Science (New York, N.Y.)
Variations on the Notch pathway in neural development.
Current opinion in neurobiology
M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.
Nature
Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary.
Proceedings of the National Academy of Sciences of the United States of America
Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors.
Proceedings of the National Academy of Sciences of the United States of America
Ligand-induced signal transduction within heterodimeric GABA(B) receptor.
Proceedings of the National Academy of Sciences of the United States of America
Asymmetric cell division in the Drosophila nervous system.
Nature reviews. Neuroscience
Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila.
Developmental cell
Dendrites.
Genes & development
Expression Profile of Aging and Oxidative Stress Response in Drosophila melanogaster.
TheScientificWorldJournal
Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis.
Current biology : CB
Controlling potassium channel activities: Interplay between the membrane and intracellular factors.
Proceedings of the National Academy of Sciences of the United States of America
Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.
Proceedings of the National Academy of Sciences of the United States of America
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Nature cell biology
Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America
Drosophila par-1 is required for oocyte differentiation and microtubule organization.
Current biology : CB
Role of ER export signals in controlling surface potassium channel numbers.
Science (New York, N.Y.)
Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.
Nature cell biology
Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain.
The Journal of biological chemistry
Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America
A genomewide survey of basic helix-loop-helix factors in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America
Heartfelt crosstalk: desensitization of the GIRK current.
Nature cell biology
Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.
Proceedings of the National Academy of Sciences of the United States of America
Mouse numb is an essential gene involved in cortical neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Staufen: a common component of mRNA transport in oocytes and neurons?
Trends in cell biology
Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.
Proceedings of the National Academy of Sciences of the United States of America
An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.
Proceedings of the National Academy of Sciences of the United States of America
Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.
The EMBO journal
atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain.
Neuron
Control of cell divisions in the nervous system: symmetry and asymmetry.
Annual review of neuroscience
Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division.
Molecular cell
Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.
Current biology : CB
Conservation of neurogenic genes and mechanisms.
Current opinion in neurobiology
Genes regulating dendritic outgrowth, branching, and routing in Drosophila.
Genes & development
Asymmetry across species.
Nature cell biology
A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.
Neuron
Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization.
Current biology : CB
Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.
Proceedings of the National Academy of Sciences of the United States of America
The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.
Proceedings of the National Academy of Sciences of the United States of America
Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.
Development (Cambridge, England)
Asymmetric cell division: lessons from flies and worms.
Current opinion in genetics & development
Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.
Genes & development
Asymmetric cell division.
Nature
Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.
Genes & development
Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Humble starts and conserved themes in neurogenetic studies.
Harvey lectures
Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo.
Molecular and cellular biology
Serendipity, the principle of limited sloppiness, and neural development.
The International journal of developmental biology
Ways and means for left shifts in the MaxiK channel.
Proceedings of the National Academy of Sciences of the United States of America
Voltage-gated and inwardly rectifying potassium channels.
The Journal of physiology
Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization.
Proceedings of the National Academy of Sciences of the United States of America
The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.
Proceedings of the National Academy of Sciences of the United States of America
Breaking symmetry in the CNS.
Trends in cell biology
Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.
Development (Cambridge, England)
Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.
Proceedings of the National Academy of Sciences of the United States of America
The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.
Development (Cambridge, England)
Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.
Proceedings of the National Academy of Sciences of the United States of America
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.
Development (Cambridge, England)
Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels.
FEBS letters
Receptor-regulated ion channels.
Current opinion in cell biology
Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters.
Current biology : CB
Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.
Proceedings of the National Academy of Sciences of the United States of America
Development. The end of the beginning?
Current opinion in neurobiology
Rho family GTP-binding proteins in growth cone signalling.
Current opinion in neurobiology
Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations.
Cold Spring Harbor symposia on quantitative biology
Cloned potassium channels from eukaryotes and prokaryotes.
Annual review of neuroscience
Reciprocal localization of Nod and kinesin fusion proteins indicates microtubule polarity in the Drosophila oocyte, epithelium, neuron and muscle.
Development (Cambridge, England)
Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development.
Cell
Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.
Proceedings of the National Academy of Sciences of the United States of America
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.
Proceedings of the National Academy of Sciences of the United States of America
Membrane permeability.
Current opinion in cell biology
Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.
Nature
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.
Genes & development
Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K(+)-selective permeation.
Biophysical journal
Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.
Neuron
A strongly inwardly rectifying K+ channel that is sensitive to ATP.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Small GTPases in axon outgrowth.
Perspectives on developmental neurobiology
Identification of structural elements involved in G protein gating of the GIRK1 potassium channel.
Neuron
dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.
The EMBO journal
Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.
The Journal of biological chemistry
CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.
The Journal of cell biology
Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors.
Development (Cambridge, England)
The molecular organization of voltage-dependent K+ channels in vivo.
Progress in brain research
Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila.
Genes & development
Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.
Proceedings of the National Academy of Sciences of the United States of America
Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.
Genes & development
lola encodes a putative transcription factor required for axon growth and guidance in Drosophila.
Development (Cambridge, England)
Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte.
Current biology : CB
daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo.
Development (Cambridge, England)
The role of gene cassettes in axis formation during Drosophila oogenesis.
Trends in genetics : TIG
Images of purified Shaker potassium channels.
Current biology : CB
Neuronal cell fate specification in Drosophila.
Current opinion in neurobiology
Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore.
Nature
Genetic control of cell fate specification in Drosophila peripheral nervous system.
Annual review of genetics
Assembly of potassium channels.
Annals of the New York Academy of Sciences
pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber.
Development (Cambridge, England)
Functional gene cassettes in development.
Proceedings of the National Academy of Sciences of the United States of America
The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors.
Development (Cambridge, England)
asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation.
Development (Cambridge, England)
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel.
Nature
A central role for microtubules in the differentiation of Drosophila oocytes.
Development (Cambridge, England)
A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.
Roux's archives of developmental biology : the official organ of the EDBO
The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.
The EMBO journal
Cell interactions and gene interactions in peripheral neurogenesis.
Genes & development
Tracing neurons with a kinesin-�-galactosidase fusion protein.
Roux's archives of developmental biology : the official organ of the EDBO
Postembryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila.
Development (Cambridge, England)
Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch.
Development (Cambridge, England)
A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.
Molecular and cellular biology
deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.
Genes & development
The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.
Development (Cambridge, England)
Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel.
Science (New York, N.Y.)
Neuronal specification.
Current opinion in genetics & development
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.
Genes & development
Studying Drosophila embryogenesis with P-lacZ enhancer trap lines.
Roux's archives of developmental biology : the official organ of the EDBO
Structural elements involved in specific K+ channel functions.
Annual review of physiology
The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.
The EMBO journal
Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.
Genes & development
Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.
Genes & development
Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence.
Nature
Genetic and molecular bases of neurogenesis in Drosophila melanogaster.
Annual review of neuroscience
Genes required for specifying cell fates in Drosophila embryonic sensory nervous system.
Trends in neurosciences
A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila.
Development (Cambridge, England)
How might the diversity of potassium channels be generated?
Trends in neurosciences
Patterns of expression of cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.
Genes & development
Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity.
Development (Cambridge, England)
rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.
Genes & development
Molecular studies of voltage-gated potassium channels.
Cold Spring Harbor symposia on quantitative biology
Role of helix-loop-helix proteins in Drosophila neurogenesis.
Cold Spring Harbor symposia on quantitative biology
The determination of sense organs in Drosophila: interaction of scute with daughterless.
Roux's archives of developmental biology : the official organ of the EDBO
A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate).
The EMBO journal
Identification of a component of Drosophila polar granules.
Development (Cambridge, England)
The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.
Genes & development
Identification and characterization of a neuron-specific nuclear antigen in Drosophila.
Science (New York, N.Y.)
Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.
Science (New York, N.Y.)
Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.
Science (New York, N.Y.)
Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta.
Proceedings of the National Academy of Sciences of the United States of America
Morphological differentiation of the embryonic peripheral neurons in Drosophila.
Roux's archives of developmental biology : the official organ of the EDBO
Muscle connections between imaginal discs in Drosophila.
Developmental biology
The LHRH family of peptide messengers in the frog nervous system.
Progress in brain research
Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mutating a gene for a potassium channel by hybrid dysgenesis: an approach to the cloning of the Shaker locus in Drosophila.
Cold Spring Harbor symposia on quantitative biology
Peptides in neuronal function: studies using frog autonomic ganglia.
Cold Spring Harbor symposia on quantitative biology
Some features of peptidergic transmission.
Progress in brain research
Peptidergic transmission in sympathetic ganglia of the frog.
The Journal of physiology
Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.
Proceedings of the National Academy of Sciences of the United States of America
Role of an LHRH-like peptide as a neurotransmitter is sympathetic ganglia of the frog.
Federation proceedings
Further evidence for peptidergic transmission in sympathetic ganglia.
Proceedings of the National Academy of Sciences of the United States of America
Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.
The Journal of cell biology
A Drosophila mutant with a temperature-sensitive block in nerve conduction.
Proceedings of the National Academy of Sciences of the United States of America
Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction.
Proceedings of the National Academy of Sciences of the United States of America
Two mutations of synaptic transmission in Drosophila.
Proceedings of the Royal Society of London. Series B, Biological sciences
L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction.
The Journal of physiology
Properties of the larval neuromuscular junction in Drosophila melanogaster.
The Journal of physiology
dunce, a mutant of Drosophila deficient in learning.
Proceedings of the National Academy of Sciences of the United States of America
Avoidance response, house response, and wind responses of the sporangiophore of Phycomyces.
The Journal of general physiology
[Bacterial endocarditis in children associated with congenital cardiopathies: clinical aspects and outcome. Apropos of 22 cases].
Archives francaises de pediatrie