
Professor
Medicine
+1 415 476-9732
Edward Hsiao, MD, PhD studies hormonal and genetic regulation of human skeletal diseases.
Publications
FDG-PET associations with pathological response and survival with neoadjuvant immunotherapy for melanoma.
Journal for immunotherapy of cancer
Repeated Cranial and Large-Vessel Positron Emission Tomography/Computed Tomography Scans and the Association With Structural Aortic Disease in Giant Cell Arteritis: A Five-Year Observational Study.
ACR open rheumatology
Palovarotene in fibrodysplasia ossificans progressiva: review and perspective.
Expert opinion on pharmacotherapy
Baseline Nodal Status on 68Ga-PSMA-11 Positron Emission Tomography/Computed Tomography in Men with Intermediate- to High-risk Prostate Cancer Is Prognostic for Treatment Failure: Follow-up of the proPSMA Trial.
European urology oncology
Personalized Approaches to Spine Surgery.
International journal of spine surgery
The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: A review of the literature.
Critical reviews in oncology/hematology
Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system.
Nature communications
Inhibition of choroidal osteoma progression using bisphosphonate and RANKL-inhibitory treatment.
American journal of ophthalmology case reports
Long term use of interleukin-1 inhibitors reduce flare activity in patients with fibrodysplasia ossificans progressiva.
Rheumatology (Oxford, England)
MMP-9 deficiency confers resilience in Fibrodysplasia Ossificans Progressiva in a man and mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification.
Biomolecules
Study methodology and insights from the palovarotene clinical development program in fibrodysplasia ossificans progressiva.
BMC medical research methodology
Frontal bone loss following coronal brow lift: A mimicker of head variant linear morphea.
JAAD case reports
Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.
Nature communications
EML4::ALK fusions in complex lymphatic malformations.
Pediatric blood & cancer
A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy.
Calcified tissue international
Improving care pathways for people living with rare bone diseases (RBDs): outcomes from the first RBD Summit.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Most Fractures Treated Nonoperatively in Individuals With Fibrodysplasia Ossificans Progressiva Heal With a Paucity of Flareups, Heterotopic Ossification, and Loss of Mobility.
Clinical orthopaedics and related research
Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
Small (Weinheim an der Bergstrasse, Germany)
A follow-up report on the published paper Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.
Orphanet journal of rare diseases
Reduction of New Heterotopic Ossification (HO) in the Open-Label, Phase 3 MOVE Trial of Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The effects of palovarotene in patients with fibrodysplasia ossificans progressiva: a plain language summary.
Future Rare Diseases
Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H -Specific Human Cellular and Zebrafish Models.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
PSAT208 A Case of Hypercalcemia From PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy.
Journal of the Endocrine Society
Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.
Nature communications
The natural history of fibrodysplasia ossificans progressiva: A prospective, global 36-month study.
Genetics in medicine : official journal of the American College of Medical Genetics
Identification of Risk Factors in the Development of Heterotopic Ossification After Primary Total Hip Arthroplasty.
The Journal of clinical endocrinology and metabolism
Palovarotene for Fibrodysplasia Ossificans Progressiva (FOP): Results of a Randomized, Placebo-Controlled, Double-Blind Phase 2 Trial.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles.
Human gene therapy
ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.
Pain
Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.
Orphanet journal of rare diseases
The Clinical Significance of Small Vessel Vasculitis on Temporal Artery Biopsies.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs.
Medical education online
Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop.
Frontiers in endocrinology
Social and Clinical Impact of COVID-19 on Patients with Fibrodysplasia Ossificans Progressiva.
Research square
Prevalence of fibrodysplasia ossificans progressiva (FOP) in the United States: estimate from three treatment centers and a patient organization.
Orphanet journal of rare diseases
Whole-body Computed Tomography Versus Dual Energy X-ray Absorptiometry for Assessing Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva.
Calcified tissue international
Global Wnt Inhibition With a Porcupine Inhibitor Decreases Established Trabecular Bone in a Mouse Model of Fibrous Dysplasia.
Journal of the Endocrine Society
[177Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial.
Lancet (London, England)
A Global Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes.
Osteologie/Osteology
Longitudinal and Flare-Up-Specific Biomarkers in Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.
Osteologie/Osteology
Medications Used by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.
Osteologie/Osteology
Use of Assistive Devices and Adaptations by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study.
Osteologie/Osteology
Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices.
Academic medicine : journal of the Association of American Medical Colleges
A natural history study of fibrodysplasia ossificans progressiva (FOP): 12-month outcome results.
Bone reports
A global natural history study of Fibrodysplasia Ossificans Progressiva (FOP): 12-month outcomes.
Endocrine Abstracts
Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.
Orphanet journal of rare diseases
MON-348 Surgical Management of Bilateral Hip Fracture in a Patient with Fibrodysplasia Ossificans Progressiva Treated with Palovarotene.
Journal of the Endocrine Society
MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function.
Journal of the Endocrine Society
OR29-05 A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes.
Journal of the Endocrine Society
SUN-344 Patients with Fibrodysplasia Ossificans Progressiva Have an Increased Prevalence of Cardiac Conduction Abnormalities.
Journal of the Endocrine Society
SUN-368 Wnt Inhibition Decreases Trabecular Bone in a Mouse Model of Fibrous Dysplasia.
Journal of the Endocrine Society
Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-? agonist palovarotene: a case report.
BMC musculoskeletal disorders
Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome.
Frontiers in endocrinology
Inflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification.
Current osteoporosis reports
Palovarotene inhibits the development of new heterotopic ossification in fibrodysplasia ossificans progressiva (FOP).
Bone Abstracts
Correction to: Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes.
Orphanet journal of rare diseases
Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes.
Orphanet journal of rare diseases
Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures.
Journal of tissue engineering and regenerative medicine
Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management.
Journal of medical imaging and radiation oncology
Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.
British journal of clinical pharmacology
NF-?B/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
JCI insight
Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP).
British journal of clinical pharmacology
FET PET in the evaluation of indeterminate brain lesions on MRI: Differentiating glioma from other non-neoplastic causes - A pilot study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Role of DOTATATE-PET/CT in preoperative assessment of phaeochromocytoma and paragangliomas.
Clinical endocrinology
68 Ga-PSMA-PET/CT staging prior to definitive radiation treatment for prostate cancer.
Asia-Pacific journal of clinical oncology
Fibrodysplasia ossificans progressiva: a current review of imaging findings.
Skeletal radiology
Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva.
Bone
Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice.
Endocrinology
Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.
Bone
The Impact of 68Ga-PSMA PET/CT on Management Intent in Prostate Cancer: Results of an Australian Prospective Multicenter Study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Uptake in sympathetic ganglia on 68 Ga-PSMA-HBED PET/CT: A potential pitfall in scan interpretation.
Journal of medical imaging and radiation oncology
International physician survey on management of FOP: a modified Delphi study.
Orphanet journal of rare diseases
Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming.
Stem cell research & therapy
Cerebellar Metastases From Prostate Cancer on 68Ga-PSMA PET/CT.
Clinical nuclear medicine
Neurosarcoidosis on FET and FDG PET/CT.
Clinical nuclear medicine
EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.
Stem cell reports
Subacute Cortical Infarct Showing Uptake on 68Ga-PSMA PET/CT.
Clinical nuclear medicine
Serous Cystadenoma of the Pancreas Showing Uptake on 68Ga PSMA PET/CT.
Clinical nuclear medicine
Delineating biochemical failure with 68Ga-PSMA-PET following definitive external beam radiation treatment for prostate cancer.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Incidental Finding of Cerebellar Medulloblastoma on 68Ga-DOTATATE PET/CT in a Patient With Appendiceal Carcinoid.
Clinical nuclear medicine
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
Proceedings of the National Academy of Sciences of the United States of America
Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Schwannoma Showing Avid Uptake on 68Ga-PSMA-HBED-CC PET/CT.
Clinical nuclear medicine
The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
Stem cell research & therapy
A Novel T55A Variant of Gs a Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis.
Case reports in endocrinology
Metastatic Renal Cell Carcinoma in the Thyroid Gland and Pancreas Showing Uptake on 68Ga DOTATATE PET/CT Scan.
Clinical nuclear medicine
Desmoid Tumor Showing Intense Uptake on 68Ga PSMA-HBED-CC PET/CT.
Clinical nuclear medicine
Follicular Lymphoma Showing Avid Uptake on 68Ga PSMA-HBED-CC PET/CT.
Clinical nuclear medicine
Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.
Bone reports
Follicular Thyroid Adenoma Showing Avid Uptake on 68Ga PSMA-HBED-CC PET/CT.
Clinical nuclear medicine
Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice.
Endocrinology
Using Human Induced Pluripotent Stem Cells to Model Skeletal Diseases.
Methods in molecular biology (Clifton, N.J.)
A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.
Calcified tissue international
Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.
The Journal of clinical endocrinology and metabolism
Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Chronic recurrent multifocal osteomyelitis with an atypical presentation in an adult man.
Skeletal radiology
Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.
Experimental cell research
Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.
Nature neuroscience
Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
Orphanet journal of rare diseases
Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.
Cell stem cell
Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
Blood
Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor.
Calcified tissue international
Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.
Stem cell research & therapy
Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance.
Circulation research
Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation.
Molecular endocrinology (Baltimore, Md.)
Combined anatomic and perfusion imaging of the heart.
Current cardiology reports
Engineering GPCR signaling pathways with RASSLs.
Nature methods
Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter.
PloS one
Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.
Proceedings of the National Academy of Sciences of the United States of America
Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
Proceedings of the National Academy of Sciences of the United States of America
A Series of RASSLs Activated by a Single Agonist.
The FASEB Journal
Melanoma metastases in regional lymph nodes are accurately detected by proton magnetic resonance spectroscopy of fine-needle aspirate biopsy samples.
Annals of surgical oncology
Growth differentiation factor-15: induction in liver injury through p53 and tumor necrosis factor-independent mechanisms.
The Journal of surgical research
An unusual development.
The American journal of medicine
Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury.
Shock (Augusta, Ga.)
Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.
The Journal of clinical endocrinology and metabolism
Diagnostic I-123 scintigraphy to assess potential breast uptake of I-131 before radioiodine therapy in a postpartum woman with thyroid cancer.
Clinical nuclear medicine
Cases from the Osler medical service at Johns Hopkins University.
The American journal of medicine
Transient absence of hepatic uptake on gallium-67 scintigraphy following fludarabine therapy.
Clinical nuclear medicine
Pericarditis associated with cryptococcal meningitis on Ga-67 scintigraphy.
Clinical nuclear medicine
Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration.
Journal of immunology (Baltimore, Md. : 1950)