
Professor
CVRI
Akiko Hata, PhD studies mechanisms of growth factor signaling in the control of cell growth and differentiation of vascular cells.
Publications
Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response
Nature Cardiovasc. Res.
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
Journal of medicinal chemistry
Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension.
International journal of molecular sciences
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.
Nature communications
How do you mend inactive tumor suppressor mutants? You glue them!
Cell chemical biology
Control of ribosomal protein synthesis by the Microprocessor complex.
Science signaling
Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.
Current opinion in hematology
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
Communications biology
Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.
American journal of physiology. Heart and circulatory physiology
Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
Science signaling
The role of TGF-β superfamily signaling in neurological disorders.
Acta biochimica et biophysica Sinica
Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.
Nature communications
Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.
Science signaling
TGF-� Signaling from Receptors to Smads.
Cold Spring Harbor perspectives in biology
Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.
Science signaling
Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-� Signaling.
Methods in molecular biology (Clifton, N.J.)
Dysregulation of microRNA biogenesis machinery in cancer.
Critical reviews in biochemistry and molecular biology
Targeting BMP signalling in cardiovascular disease and anaemia.
Nature reviews. Cardiology
Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease.
Circulation journal : official journal of the Japanese Circulation Society
Dysregulation of microRNA biogenesis and gene silencing in cancer.
Science signaling
Functions of the bone morphogenetic protein signaling pathway through microRNAs (review).
International journal of molecular medicine
Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation.
Journal of cellular biochemistry
Cardiovascular applications of therapeutic ultrasound.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress.
The EMBO journal
Atrial natriuretic peptide is negatively regulated by microRNA-425.
The Journal of clinical investigation
Role of microRNAs in lung development and pulmonary diseases.
Pulmonary circulation
Regulation of miRNA biogenesis as an integrated component of growth factor signaling.
Current opinion in cell biology
Functions of microRNAs in cardiovascular biology and disease.
Annual review of physiology
Targeting the TGF� signalling pathway in disease.
Nature reviews. Drug discovery
Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway.
The Journal of biological chemistry
Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.
The Journal of biological chemistry
MicroRNA regulation of smooth muscle gene expression and phenotype.
Current opinion in hematology
A taste of TGF� in Tuscany.
Development (Cambridge, England)
Smad-mediated regulation of microRNA biosynthesis.
FEBS letters
Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.
The Journal of biological chemistry
MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling.
Cardiovascular research
Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation.
Arteriosclerosis, thrombosis, and vascular biology
Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.
Molecular and cellular biology
down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4.
The Journal of biological chemistry
Regulation of pri-miRNA Processing Through Smads.
Advances in experimental medicine and biology
The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway.
Molecular and cellular biology
MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways.
Genes & cancer
Mechanisms of control of microRNA biogenesis.
Journal of biochemistry
Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.
Molecular cell
Regulation of pri-miRNA processing through Smads.
Advances in experimental medicine and biology
Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.
The EMBO journal
Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus.
Cytokine & growth factor reviews
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms.
Cell communication and signaling : CCS
The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone.
The Journal of biological chemistry
Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype.
The Journal of biological chemistry
Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.
The Journal of biological chemistry
A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.
Molecular and cellular biology
BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology
OAZ regulates bone morphogenetic protein signaling through Smad6 activation.
The Journal of biological chemistry
Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors.
Molecular and cellular biology
Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway.
The Journal of biological chemistry
Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.
Biochemical and biophysical research communications
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan.
The Journal of biological chemistry