
Professor
Bioengineering
+1 415 502-4949
Su Guo, PhD uses molecular genetic approaches in zebrafish to identify novel genes involved in fate determination of dopaminergic neurons.
Publications
Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors.
Science advances
Protocol for image-based small-molecule screen to identify neuroprotective compounds for dopaminergic neurons in zebrafish.
STAR protocols
Methods For Visualizing Intracellular Organelles.
Journal of visualized experiments : JoVE
Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors.
Journal of visualized experiments : JoVE
Correction to: Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons.
Molecular psychiatry
Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons.
Molecular psychiatry
In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets.
Frontiers in pharmacology
The effect of renin-angiotensin-aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19.
Scientific reports
THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.
Scientific reports
Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding.
Learning & memory (Cold Spring Harbor, N.Y.)
Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division.
Science advances
Complexity of Detecting CRISPR/Cas9-Mediated Homologous Recombination in Zebrafish.
Molecular Biology
Heritable natural variation of light/dark preference in an outbred zebrafish population.
Journal of neurogenetics
Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.
Cell chemical biology
A novel PRRT2 pathogenic variant in a family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures.
Cold Spring Harbor molecular case studies
Chapter 16 Systematic Screens in Zebrafish Shed Light on Cellular and Molecular Mechanisms of Complex Brain Phenotypes
.
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research
Heritable natural variation of an anxiety-like behavior in larval zebrafish.
Journal of neurogenetics
Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model.
Development, growth & differentiation
Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo
Protein Sci.
Open-top selective plane illumination microscope for conventionally mounted specimens.
Optics express
PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.
Cell metabolism
Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells.
Biochemical and biophysical research communications
Understanding neurotransmitter-neuropeptide regulation through neural circuits controlling innate behaviour.
International Journal of Developmental Neuroscience
Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors.
Developmental neurobiology
The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons.
Human molecular genetics
Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes.
The Journal of biological chemistry
Time-lapse live imaging of clonally related neural progenitor cells in the developing zebrafish forebrain.
Journal of visualized experiments : JoVE
Conditioned place preference behavior in zebrafish.
Nature protocols
Identification of a brain center whose activity discriminates a choice behavior in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America
Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish.
Behavioural brain research
Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Preference for ethanol in zebrafish following a single exposure.
Behavioural brain research
The importance of being cis: evolution of orthologous fish and mammalian enhancer activity.
Molecular biology and evolution
Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes.
Neurobiology of disease
Camouflage response in zebrafish: A model for genetic dissection of molecular and cellular circuitries underlying alcoholism.
Communicative & integrative biology
A systematic approach to identify functional motifs within vertebrate developmental enhancers.
Developmental biology
The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods.
The Journal of comparative neurology
Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy.
Pharmacogenomics
Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Using zebrafish to assess the impact of drugs on neural development and function.
Expert opinion on drug discovery
fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain.
Gene expression patterns : GEP
7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.
Proceedings of the National Academy of Sciences of the United States of America
Communicative &
Integrative Biology
Camouflage response in zebrafish: A
model for genetic dissection of molecular and cellular circuitries underlying Alcoholism
Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo.
PloS one
cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation.
Bioinformatics (Oxford, England)
Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression.
The Journal of comparative neurology
Animal Models for Anxiety Disorders.
Biomarkers for Psychiatric Disorders
Biomarkers for Psychiatric Disorders
Animal models for anxiety disorders
Chapter 23 Insights from Zebrafish PD Models and Their Potentials for Identifying Novel Drug Targets and Therapeutic Compounds.
Parkinson\u0027s Disease
Parkinson’s Disease: Pathogenic and Therapeutic Insights from Toxin and Genetic Models
Insights from zebrafish PD models, and their potential for identifying novel drug targets and therapeutic compounds
Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl.
Development (Cambridge, England)
A subunit of the mediator complex regulates vertebrate neuronal development.
Proceedings of the National Academy of Sciences of the United States of America
Dissociation of food and opiate preference by a genetic mutation in zebrafish.
Genes, brain, and behavior
Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl.
Proceedings of the National Academy of Sciences of the United States of America
Antipsychotics produce locomotor impairment in larval zebrafish.
Neurotoxicology and teratology
Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease.
Neurotoxicology and teratology
A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion.
Molecular microbiology
Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish?
Genes, brain, and behavior
Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening.
Pharmacology, biochemistry, and behavior
The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain.
Neuroscience
The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons.
Development (Cambridge, England)
A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination.
Journal of neurochemistry
Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects.
Pharmacology, biochemistry, and behavior
Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons.
Developmental biology
Chapter 2.1.8 Mutagenesis in zebra fish: studying the brain dopamine systems.
Handbook of Molecular-Genetic Techniques for Brain and Behavior Research
Handbook of Molecular Genetic Techniques for Brain and Behavior Research
Mutagenesis in zebrafish: studying the brain dopamine systems
PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.
Development (Cambridge, England)
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.
Development (Cambridge, England)
Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo.
Current opinion in genetics & development