
Professor
Surgery
Tobias Deuse, MD is developing immune editing strategies to shield stem cells and cell products from immune recognition and rejection. He develops immune-oncology therapeutics and regenerative cell therapies based on this concept.
Publications
Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation.
Nature communications
Hydroxocobalamin for the treatment of vasoplegia after lung transplantation: A case series.
JHLT open
Clinical Improvement With Transcatheter Edge-to-Edge Tricuspid Repair Irrespective of Right Atrial Pressure.
JACC. Advances
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.
Cell stem cell
Four Decades of Progress in Heart-Lung Transplantation: 271 Cases at a Single Institution.
The Journal of thoracic and cardiovascular surgery
Lung Transplantation in Patients with Cystic Fibrosis: A Complex Task, A Changing Target.
Journal of cardiothoracic and vascular anesthesia
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.
Cell stem cell
Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
Nature biotechnology
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.
Science translational medicine
Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.
Nature communications
Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.
Nature biotechnology
Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery.
Journal of cardiothoracic and vascular anesthesia
Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
Nature biotechnology
Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study.
Pain and therapy
Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
Proceedings of the National Academy of Sciences of the United States of America
Shock, Thrombus, TAVR: A Challenging TAVR With Large Left-Ventricular Thrombus.
The Canadian journal of cardiology
Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.
Stem cells and development
The SIRPa-CD47 immune checkpoint in NK cells.
The Journal of experimental medicine
Outcomes of transcatheter aortic valve replacement in end stage liver and renal disease.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Subxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA�Ligation: Initial Sub-X Hybrid MAZE Registry Results.
JACC. Clinical electrophysiology
Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.
Frontiers in physiology
The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.
Stem cells and development
Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation.
Seminars in thoracic and cardiovascular surgery
Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant - a historical prospective study.
Transplant international : official journal of the European Society for Organ Transplantation
A Cryoinjury Model to Study Myocardial Infarction in the Mouse.
Journal of visualized experiments : JoVE
De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
Nature biotechnology
Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis.
Open forum infectious diseases
Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
Nature biotechnology
Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections.
Case reports in infectious diseases
Analysis of Minimally Invasive Left Thoracotomy HVAD Implantation - A Single-Center Experience.
The Thoracic and cardiovascular surgeon
Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study.
Transplant international : official journal of the European Society for Organ Transplantation
Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.
The Lancet. Respiratory medicine
Hybrid Open Minimally Invasive Transcatheter Mitral Valve Replacement.
The Annals of thoracic surgery
Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.
Journal of visualized experiments : JoVE
Hybrid and surgical procedures for the treatment of persistent and longstanding persistent atrial fibrillation.
Expert review of cardiovascular therapy
Outcomes of Minimally Invasive Temporary Right Ventricular Assist Device Support for Acute Right Ventricular Failure During Minimally Invasive Left Ventricular Assist Device Implantation.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.
Transplant international : official journal of the European Society for Organ Transplantation
Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.
Comparative medicine
Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections�.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Lobar lung transplantation from deceased donors: A systematic review.
World journal of transplantation
Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.
Journal of visualized experiments : JoVE
Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.
Transplant international : official journal of the European Society for Organ Transplantation
Acute Pulmonary Artery Obstruction as the Primary Manifestation of a Rapidly Growing Intimal Sarcoma in a 54-Year-Old Patient.
The Thoracic and cardiovascular surgeon reports
A matched pairs analysis of non-rib-spreading, fully endoscopic, mini-incision technique versus conventional mini-thoracotomy for mitral valve repair.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.
Transplantation
The MANDELA study: A multicenter, randomized, open-label, parallel group trial to refine the use of everolimus after heart transplantation.
Contemporary clinical trials
Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.
BioMed research international
Distal Airway Stem Cells are Essential for Lung Regeneration.
Transplantation
Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.
Arteriosclerosis, thrombosis, and vascular biology
Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.
Transplantation
Immunobiology of fibrin-based engineered heart tissue.
Stem cells translational medicine
Concomitant minimally invasive HVAD and transapical aortic valve implantation.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.
Cell stem cell
Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression.
Transplant international : official journal of the European Society for Organ Transplantation
Isolated permanent right ventricular assist device implantation with the HeartWare continuous-flow ventricular assist device: first results from the European Registry for Patients with Mechanical Circulatory Support.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Clinical experience of combined HeartWare ventricular assist device and implantable cardioverter defibrillator therapy.
Journal of cardiovascular electrophysiology
Introduction of the lung allocation score in Germany.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.
Journal of visualized experiments : JoVE
Minimally invasive implantation of biventricular assist devices.
The Thoracic and cardiovascular surgeon
Do not touch the sternum--thoracotomy incisions for HVAD implantation.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Efficacy of prophylactic intra-aortic balloon pump therapy in chronic heart failure patients undergoing cardiac surgery.
Artificial organs
Dual-chamber pacemaker implantation with left ventricular pacing in a patient with a right ventricular assist device.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
HVAD continuous flow assist device for ischemic ventricular septal rupture.
The Journal of thoracic and cardiovascular surgery
Mechanically induced ventricular tachycardia by the HeartWare ventricular assist device.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Everolimus in heart transplantation: an update.
Journal of transplantation
Bortezomib rescue therapy in a patient with recurrent antibody-mediated rejection after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients.
Transplantation proceedings
Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.
Stem cells and development
Minimal access median sternotomy for aortic valve replacement in elderly patients.
Journal of cardiothoracic surgery
Isolated permanent right ventricular assistance using the HVAD continuous-flow pump.
The Annals of thoracic surgery
Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis.
Progress in transplantation (Aliso Viejo, Calif.)
ST-elevation myocardial infarction following heart transplantation as an unusual presentation of coronary allograft vasculopathy: a case report.
Transplantation proceedings
The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.
Transplantation
Severe bacterial superinfection based on influenza A (H1N1) pneumonia in a heart-lung transplant recipient.
The Thoracic and cardiovascular surgeon
Concomitant transcatheter aortic valve and left ventricular assist device implantation.
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
Transplantation
Clinical and functional correlates of early microvascular dysfunction after heart transplantation.
Circulation. Heart failure
Successful extracorporeal membrane oxygenation weaning after cardiac resynchronization therapy device implantation in a patient with end-stage heart failure.
Interactive cardiovascular and thoracic surgery
Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.
Journal of visualized experiments : JoVE
Cardiac paraganglioma: diagnostic and surgical challenges.
Journal of cardiac surgery
Immunobiology of na�ve and genetically modified HLA-class-I-knockdown human embryonic stem cells.
Journal of cell science
Surgical technique of lower lobe lung transplantation.
The Annals of thoracic surgery
Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).
Journal of visualized experiments : JoVE
Minimally invasive resection of a right atrial mass in a cardiac transplant recipient: a case report.
Transplantation proceedings
Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients.
Transplantation
Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.
Journal of visualized experiments : JoVE
Transcatheter aortic valve implantation in a heart transplant recipient: a case report.
Transplantation proceedings
Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.
Cell transplantation
Review of heart-lung transplantation at Stanford.
The Annals of thoracic surgery
Non-volume-loaded heart provides a more relevant heterotopic transplantation model.
Transplant immunology
Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease.
Journal of visualized experiments : JoVE
Asymptomatic infection with novel influenza A/H1N1 virus in a heart transplant recipient.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation.
American journal of respiratory cell and molecular biology
Changing trends in infectious disease in heart transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
LAD-ligation: a murine model of myocardial infarction.
Journal of visualized experiments : JoVE
Alternative technique for salvage of donor lungs with insufficient atrial cuffs.
The Annals of thoracic surgery
Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.
Journal of visualized experiments : JoVE
Heart-lung transplantation in situs inversus totalis.
The Annals of thoracic surgery
Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Heart transplantation in situs inversus totalis.
The Journal of thoracic and cardiovascular surgery
Twenty-year survivors of heart transplantation at Stanford University.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection.
Transplantation
Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.
Transplantation
Introducing the first polymer-free leflunomide eluting stent.
Atherosclerosis
Fluoroscopy to assess late heart and lung perforation by a permanent ventricular pacemaker lead. A case complicated by isolated hemothorax.
International journal of cardiology
Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?
Transplantation proceedings
Stem cell transplantation: the lung barrier.
Transplantation proceedings
Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?
Transplant immunology
Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells.
Stem cells and development
FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.
Menopause (New York, N.Y.)
Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
Circulation
FK778: new cellular and molecular mechanisms of action.
Transplantation proceedings
Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
Transplant international : official journal of the European Society for Organ Transplantation
Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium.
Transplantation proceedings
The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.
Transplant immunology
FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.
Transplant international : official journal of the European Society for Organ Transplantation
Video and robotic-assisted minimally invasive mitral valve surgery: a comparison of the Port-Access and transthoracic clamp techniques.
The Annals of thoracic surgery
FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
Transplantation
The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.
Transplantation
Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.
Transplantation
Successful resection of a symptomatic right ventricular lipoma.
The Annals of thoracic surgery
Robotically assisted coronary artery bypass surgery with the ZEUS telemanipulator system.
Seminars in thoracic and cardiovascular surgery
Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the rat.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
Early and midterm results after coronary artery bypass grafting with and without cardiopulmonary bypass: which patient population benefits the most?
The heart surgery forum
Midterm results and quality of life after minimally invasive vs. conventional aortic valve replacement.
The Thoracic and cardiovascular surgeon
Comparison of two stabilizer concepts for off-pump coronary artery bypass grafting.
The Annals of thoracic surgery
Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation.
Medical science monitor : international medical journal of experimental and clinical research
Effect of hemodynamics on graft rejection in the heterotopic heart transplantation model.
Transplantation proceedings