
Professor
HDCCC
+1 415 502-4180
Allan Balmain, PhD focuses on the role of stem cells in skin and lung cancer. His goal is to identify the critical tumor-originating cells and the mechanisms by which they become transformed, which will aid in both stem cell therapy and cancer therapy.
Publications
Long term latency of highly mutated cells in normal mouse skin is reversed by exposure to tumor promoters and chronic tissue damage.
Cancer discovery
Stem-cell states converge in multistage cutaneous squamous cell carcinoma development.
Science (New York, N.Y.)
Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression.
Cold Spring Harbor perspectives in medicine
Gene networks reveal stem-cell state convergence during preneoplasia and progression to malignancy in multistage skin carcinogenesis.
bioRxiv : the preprint server for biology
Peto's paradox revisited: black box vs mechanistic approaches to understanding the roles of mutations and promoting factors in cancer.
European journal of epidemiology
Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients.
Skin health and disease
Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3VNTR polymorphisms and gene co-expression.
NPJ breast cancer
Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells.
Nature communications
The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk.
Nature genetics
Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility.
Nature communications
Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice.
Nature communications
Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin.
Developmental cell
α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.
Journal for immunotherapy of cancer
A model for RAS mutation patterns in cancers: finding the sweet spot.
Nature reviews. Cancer
Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis.
Nature cell biology
Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue.
Oncoimmunology
Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.
Genome medicine
Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer.
Cell reports
Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers.
Nature medicine
The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development.
Molecular carcinogenesis
Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.
Nature communications
The genetics of splicing in neuroblastoma.
Cancer discovery
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.
Molecular cancer research : MCR
Milestones in skin carcinogenesis: the biology of multistage carcinogenesis.
The Journal of investigative dermatology
Modeling cutaneous squamous carcinoma development in the mouse.
Cold Spring Harbor perspectives in medicine
A multilevel model of postmenopausal breast cancer incidence.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Identification of Hipk2 as an essential regulator of white fat development.
Proceedings of the National Academy of Sciences of the United States of America
Cellular reprogramming in skin cancer.
Seminars in cancer biology
The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.
Molecular oncology
Keratin 16 regulates innate immunity in response to epidermal barrier breach.
Proceedings of the National Academy of Sciences of the United States of America
Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
The Journal of allergy and clinical immunology
Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.
Genes & development
Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology.
The Journal of investigative dermatology
Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.
Clinical cancer research : an official journal of the American Association for Cancer Research
Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.
Nature communications
Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice.
The Journal of investigative dermatology
Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
Molecular cancer research : MCR
Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer.
Molecular cancer research : MCR
Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity.
Genes & development
Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility.
Genome biology
C/EBPd: friend or foe? a novel role for C/EBPd in metastasis.
The EMBO journal
Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Guidelines for the welfare and use of animals in cancer research.
British journal of cancer
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.
Oncogene
An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis.
Oncogene
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.
American journal of medical genetics. Part A
Systems genetics analysis of cancer susceptibility: from mouse models to humans.
Nature reviews. Genetics
Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus.
BMC genomics
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Science (New York, N.Y.)
Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer.
The American journal of pathology
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America
A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.
Nature genetics
Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.
Proceedings of the National Academy of Sciences of the United States of America
Crosstalk between Pten and Ras signaling pathways in tumor development.
Cell cycle (Georgetown, Tex.)
Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway.
Cancer research
Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.
Carcinogenesis
Mapping segmental and sequence variations among laboratory mice using BAC array CGH.
Genome research
Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Forty years of cancer modelling in the mouse.
European journal of cancer (Oxford, England : 1990)
Genomic segmental polymorphisms in inbred mouse strains.
Nature genetics
Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.
Genes & development
A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Cancer: dangerous liaisons.
Nature
Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma.
The Journal of investigative dermatology
The genetics of cancer susceptibility: from mouse to man.
Toxicologic pathology
Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants.
Journal of virology
Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice.
Cancer research
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.
Nature genetics
Stem-cell hierarchy in skin cancer.
Nature reviews. Cancer
The genetics and genomics of cancer.
Nature genetics
Developing novel oncolytic adenoviruses through bioselection.
Journal of virology
Genomic approaches to identification of tumour-susceptibility genes using mouse models.
Current opinion in genetics & development
Novel approaches to identify low-penetrance cancer susceptibility genes using mouse models.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Nature cell biology
High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling.
The Journal of biological chemistry
Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays.
Nature biotechnology
Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
Molecular and cellular biology
Building 'validated' mouse models of human cancer.
Current opinion in cell biology
Cancer genetics: from Boveri and Mendel to microarrays.
Nature reviews. Cancer
TGF-beta signaling in tumor suppression and cancer progression.
Nature genetics
Role of matrix metalloproteinase-9 in progression of mouse skin carcinogenesis.
Molecular carcinogenesis
Epistatic interactions between skin tumor modifier loci in interspecific (spretus/musculus) backcross mice.
Cancer research
Allele-specific loss or imbalance of chromosomes 9, 15, and 16 in B-cell tumors from interspecific F1 hybrid mice carrying Emu-c-myc or N-myc transgenes.
International journal of cancer
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest.
Genes & development
Productive replication of human adenoviruses in mouse epidermal cells.
Journal of virology
Integration of positive and negative growth signals during ras pathway activation in vivo.
Current opinion in genetics & development
Targeting gene expression to tumor cells with loss of wild-type p53 function.
Cancer gene therapy
A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.
Proceedings of the National Academy of Sciences of the United States of America
Target genes and target cells in carcinogenesis.
British journal of cancer
Oncogenes and cell proliferation.
Current opinion in genetics & development
Genetic events and the role of TGF beta in epithelial tumour progression.
The Journal of pathology
Epithelial carcinogenesis in the mouse: correlating the genetics and the biology.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted.
Current biology : CB
Cancer resistance genes in mice: models for the study of tumour modifiers.
Trends in genetics : TIG
Stochastic modelling of tumorigenesis in p53 deficient mice.
British journal of cancer
Chromosomal and genetic alterations of 7,12-dimethylbenz[a]anthracene-induced melanoma from TP-ras transgenic mice.
Molecular carcinogenesis
Altered epidermal cell growth control in vivo by inducible expression of transforming growth factor beta 1 in the skin of transgenic mice.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice.
International journal of cancer
Multigenic control of skin tumour development in mice.
Ciba Foundation symposium
Transgenic approaches to understanding the mechanisms of chemical carcinogenesis in mouse skin.
Toxicology letters
Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors.
Cancer research
Cancer. Exploring the bowels of DNA methylation.
Current biology : CB
Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice.
Cancer research
Distinct genetic loci control development of benign and malignant skin tumours in mice.
Nature genetics
Transgenic mice and squamous multistage skin carcinogenesis.
Cancer metastasis reviews
Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice.
Genes & development
Regulatory elements in the first intron of the mouse Ha-ras gene.
Molecular carcinogenesis
Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter.
Molecular carcinogenesis
Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors.
Molecular carcinogenesis
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression.
Molecular carcinogenesis
An allelotype of squamous carcinoma of the head and neck using microsatellite markers.
Cancer research
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.
Cancer research
Importance of genetic alterations in tumour development.
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
Molecular mechanisms of invasion and metastasis during mouse skin tumour progression.
Invasion & metastasis
Transgenic approaches to the analysis of ras and p53 function in multistage carcinogenesis.
Cold Spring Harbor symposia on quantitative biology
Allelotype analysis of mouse skin tumors using polymorphic microsatellites: sequential genetic alterations on chromosomes 6, 7, and 11.
Cancer research
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event.
The Journal of cell biology
A revised map position for the Ha-ras gene on mouse chromosome 7: implications for analysis of genetic alterations in rodent tumors.
Molecular carcinogenesis
Oncogenes and tumour suppressor genes in transgenic mouse models of neoplasia.
European journal of cancer (Oxford, England : 1990)
Positive and negative growth control in multistage skin carcinogenesis.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Potential therapeutic targets in multistep oncogenesis.
Seminars in cancer biology
Discordant transforming growth factor beta 1 RNA and protein localization during chemical carcinogenesis of the skin.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.
Cancer research
Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.
Cancer research
Genetic changes during mouse skin tumorigenesis.
Environmental health perspectives
Functional loss of tumour suppressor genes in multistage chemical carcinogenesis.
Princess Takamatsu symposia
Molecular alterations in oncogenes or tumor suppressor genes during chemical carcinogenesis.
Progress in histochemistry and cytochemistry
Structural analysis of the mouse c-Ha-ras gene promoter.
Molecular carcinogenesis
Chalones revisited--a possible role for transforming growth factor beta in tumour promotion.
Carcinogenesis
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.
Proceedings of the National Academy of Sciences of the United States of America
The interplay between ras oncogenes and tumor suppressor genes in experimental carcinogenesis.
Immunology series
Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures.
Experimental cell research
Chemical induction of oncogene mutations and growth factor activity in mouse skin carcinogenesis.
Environmental health perspectives
Initiation of skin carcinogenesis can occur by induction of carcinogen-specific point mutations in the Harvey-ras gene.
Progress in clinical and biological research
The action of oncogenes and growth factors in tumour initiation and promotion.
Carcinogenesis; a comprehensive survey
Molecular analysis of chemical carcinogenesis in the skin.
The British journal of cancer. Supplement
UKCCCR guidelines for the welfare of animals in experimental neoplasia.
Laboratory animals
A human T24 Ha-ras cassette suitable for expression studies in eukaryotic cells.
Nucleic acids research
Isolation and characterization of the 5' flanking region of the mouse c-Harvey-ras gene.
Molecular carcinogenesis
Oncogene activation in chemical carcinogenesis.
Advances in cancer research
An approach to the molecular mechanisms of cancer induction.
The Journal of pathology
Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum.
British journal of cancer
Differential methylation of the c-H-ras gene in normal mouse cells and during skin tumour progression.
The EMBO journal
Transforming ras oncogenes and multistage carcinogenesis.
British journal of cancer
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas.
Nature
Identification of a rapidly labelled 350K histidine-rich protein in neonatal mouse epidermis.
Differentiation; research in biological diversity
Induction of granulocyte-macrophage colony-stimulating activity in mouse skin by inflammatory agents and tumor promoters.
The EMBO journal
Transcription of repeated sequences of the mouse B1 family in Friend erythroleukaemic cells. Intermolecular RNA-RNA duplex formation between polyadenylated and non-polyadenylated nuclear RNAs.
Journal of molecular biology
Cloning and characterisation of the abundant cytoplasmic 7S RNA from mouse cells.
Nucleic acids research
Sequence divergence of nucleus-confined polyadenylated ribonucleic acids in Friend erythroleukemic cells.
Biochemistry
Post-transcriptional control of messenger abundance.
Molecular biology reports
Frequency distribution of pre-messenger RNA sequences in polyadenylated and non-polyadenylated nuclear RNA from Friend cells.
Nucleic acids research
The effects of mercury-substitution on the hybridisation characteristics of nucleic acids.
Nucleic acids research
Protein synthesis during fetal development of mouse epidermis. II. Biosynthesis of histidine-rich and cystine-rich proteins in vitro and in vivo.
Developmental biology
Diversity and complexity of uterine mRNA from rats of differing hormonal states.
European journal of biochemistry
Qualitative and quantitative changes in uterine mRNA populations in response to oestradiol treatment of rats.
European journal of biochemistry
Nick translation of mammalian DNA.
Biochimica et biophysica acta
On the existence of 'arrested G2 cells' in mouse epidermis.
Cell and tissue kinetics
Protein synthesis during fetal development of mouse epidermis. I. The appearance of "histidine-rich protein".
Developmental biology
On the biochemical mechanism of tumorigenesis in mouse skin. VII. The effects of tumor promoters on 3H-choline and 3H-glycerol incorporation into mouse epidermal phosphatidylcholine in relation to their effects on 3H-thymidine incorporation into DNA.
Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology
The synthesis of specific proteins in adult mouse epidermis during phases of proliferation and differentiation induced by the tumor promoter TPA, and in basal and differentiating layers of neonatal mouse epidermis.
The Journal of investigative dermatology
On the biochemical mechanism of tumorigenesis in mouse skin. VI. Early effects of growth-stimulating phorbol esters on phosphate transport and phospholipid synthesis in mouse epidermis.
Biochimica et biophysica acta
Proceedings: The effects of tumour promotors on phospholipid metabolism in mouse epidermis.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie