
Professor
Microbiology and Immunology
+1 415 502-6427
Jason Cyster, PhD studies lymphocyte trafficking and homeostasis.
Publications
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions.
Nature immunology
Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis.
Cell host & microbe
Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8.
bioRxiv : the preprint server for biology
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer.
The Journal of experimental medicine
Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer.
bioRxiv : the preprint server for biology
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes.
Cell
485 A hairy story: Pain facilitating dermal TRPV1 innervations engage a macrophage and fibroblast containing pathway to activate hair growth in mice.
Journal of Investigative Dermatology
Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity.
The Journal of experimental medicine
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer.
bioRxiv : the preprint server for biology
LB869 Single-cell RNA-seq analysis of circulating immune cells in dermatomyositis in patients with and without a history of cancer.
Journal of Investigative Dermatology
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.
Genome medicine
Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice.
Developmental cell
Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells.
Science immunology
Lymphoid tissue on the mind.
Trends in immunology
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function.
Nature immunology
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling.
Nature communications
Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells.
bioRxiv : the preprint server for biology
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.
bioRxiv : the preprint server for biology
Lipid mediators in the regulation of innate and adaptive immunity.
Immunological reviews
B cell peripheral tolerance is promoted by cathepsin B protease.
Proceedings of the National Academy of Sciences of the United States of America
GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation.
Immunological reviews
Transmembrane protein CD69 acts as an S1PR1 agonist.
bioRxiv : the preprint server for biology
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells.
Nature immunology
GPR174 signals via Gas to control a CD86-containing gene expression program in B cells.
Proceedings of the National Academy of Sciences of the United States of America
Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue.
The Journal of Immunology
Structure of S1PR2-heterotrimeric G13 signaling complex.
Science advances
Chemo- and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen.
Immunological reviews
CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells.
Science (New York, N.Y.)
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
Science immunology
ILC3s control splenic cDC homeostasis via lymphotoxin signaling.
The Journal of experimental medicine
Long COVID in the skin: a registry analysis of COVID-19 dermatological duration.
The Lancet. Infectious diseases
Requirements for cDC2 positioning in blood-exposed regions of the neonatal and adult spleen.
The Journal of experimental medicine
Transcriptional regulation of memory B cell differentiation.
Nature reviews. Immunology
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Nature biotechnology
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.
Nature immunology
Organoid Polymer Functionality and Mode of Klebsiella Pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells.
Advanced functional materials
Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen.
Proceedings of the National Academy of Sciences of the United States of America
Test performance evaluation of SARS-CoV-2 serological assays.
medRxiv : the preprint server for health sciences
T follicular helper cells in germinal center B cell selection and lymphomagenesis.
Immunological reviews
Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells.
The Journal of Immunology
GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein.
The Journal of clinical investigation
Sphingosine-1-phosphate receptor 2 restrains egress of ?d T cells from the skin.
The Journal of experimental medicine
G-protein coupled receptors and ligands that organize humoral immune responses.
Immunological reviews
Loss of sterol metabolic homeostasis triggers inflammasomes?-?how and why.
Current opinion in immunology
Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity.
Proceedings of the National Academy of Sciences of the United States of America
Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.
Immunity
G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment.
Frontiers in immunology
Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Gas proteins.
Immunology and cell biology
Atypical chemokine receptor 4 shapes activated B cell fate.
The Journal of experimental medicine
GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage.
Science immunology
Distinct oxysterol requirements for positioning na�ve and activated dendritic cells in the spleen.
Science immunology
The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells.
The Journal of experimental medicine
Germinal centers: programmed for affinity maturation and antibody diversification.
Current opinion in immunology
Interfer'n with antibody responses.
Science immunology
Clathrin light chains' role in selective endocytosis influences antibody isotype switching.
Proceedings of the National Academy of Sciences of the United States of America
The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays.
Genes & development
IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Science (New York, N.Y.)
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.
The Journal of experimental medicine
Peyer's patches: organizing B-cell responses at the intestinal frontier.
Immunological reviews
The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination.
The Journal of experimental medicine
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells.
Journal of immunology (Baltimore, Md. : 1950)
Getting close to the action elicits better memories.
The Journal of experimental medicine
Inflammation induces dermal V?4+ ?dT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses.
Proceedings of the National Academy of Sciences of the United States of America
The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
The Journal of experimental medicine
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
The Journal of cell biology
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
The Journal of experimental medicine
GPR18 is required for a normal CD8aa intestinal intraepithelial lymphocyte compartment.
The Journal of experimental medicine
25-Hydroxycholesterols in innate and adaptive immunity.
Nature reviews. Immunology
Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.
Science (New York, N.Y.)
Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers.
The Journal of experimental medicine
Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness.
Journal of immunology (Baltimore, Md. : 1950)
Blown away: the unexpected role of lymphotoxin in lymphoid organ development.
Journal of immunology (Baltimore, Md. : 1950)
Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen.
Current topics in microbiology and immunology
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.
The Journal of clinical investigation
CXCR4 promotes B cell egress from Peyer's patches.
The Journal of experimental medicine
Deficiency in IL-17-committed V?4(+) ?d T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis.
Nature immunology
Immunology. When less signaling is more.
Science (New York, N.Y.)
S1PR2 links germinal center confinement and growth regulation.
Immunological reviews
Lymph node macrophages.
Journal of innate immunity
Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs.
Annual review of immunology
DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.
European journal of immunology
Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers.
The Journal of experimental medicine
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
Science (New York, N.Y.)
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.
The Journal of experimental medicine
EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950)
FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus.
Journal of immunology (Baltimore, Md. : 1950)
The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement.
Nature immunology
B cells within germinal centers migrate preferentially from dark to light zone.
Proceedings of the National Academy of Sciences of the United States of America
Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis.
Journal of immunology (Baltimore, Md. : 1950)
Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans.
The American journal of pathology
Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure.
Proceedings of the National Academy of Sciences of the United States of America
B cell follicles and antigen encounters of the third kind.
Nature immunology
Erratum: Corrigendum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Nature immunology
Visualizing influenza virus capture in the lymph node following vaccination.
Immunology and cell biology
Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.
International immunology
CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4.
The Journal of biological chemistry
Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction.
Science (New York, N.Y.)
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.
The Journal of clinical investigation
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
The Journal of cell biology
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
The Journal of experimental medicine
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Nature immunology
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
The Journal of experimental medicine
Thymic egress: S1P of 1000.
F1000 biology reports
Visualizing B cell capture of cognate antigen from follicular dendritic cells.
The Journal of experimental medicine
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation.
Nature immunology
The microanatomy of B cell activation.
Current opinion in immunology
Settling the thymus: immigration requirements.
The Journal of experimental medicine
Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids.
Nature immunology
Erratum: Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells.
Nature immunology
Severe combined immunodeficiency (SCID) and attention deficit hyperactivity disorder (ADHD) associated with a Coronin-1A mutation and a chromosome 16p11.2 deletion.
Clinical immunology (Orlando, Fla.)
Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells.
Nature immunology
A p38 MAPK-MEF2C pathway regulates B-cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Nature immunology
Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function.
Seminars in immunology
Finding a way out: lymphocyte egress from lymphoid organs.
Nature immunology
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.
Journal of immunology (Baltimore, Md. : 1950)
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.
Nature immunology
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces.
Nature immunology
Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells.
Nature immunology
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.
Science (New York, N.Y.)
CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node.
Journal of immunology (Baltimore, Md. : 1950)
Specifying the patterns of immune cell migration.
Novartis Foundation symposium
Imaging of germinal center selection events during affinity maturation.
Science (New York, N.Y.)
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism.
The Journal of experimental medicine
Spontaneous class switching and B cell hyperactivity increase autoimmunity against intracellular self antigen in Lyn-deficient mice.
European journal of immunology
Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival.
Proceedings of the National Academy of Sciences of the United States of America
B cell migration and interactions in the early phase of antibody responses.
Current opinion in immunology
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
The Journal of experimental medicine
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
Science (New York, N.Y.)
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells.
PLoS biology
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.
Immunity
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit.
The Journal of experimental medicine
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.
Annual review of immunology
Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13.
Journal of immunology (Baltimore, Md. : 1950)
Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.
Journal of immunology (Baltimore, Md. : 1950)
FTY720 BLOCKS S1P1 RECEPTOR/S1P-DEPENDENT LYMPHOCYTE EGRESS FROM LYMPHOID ORGANS – ADDITIONAL ROLE OF S1P RECEPTORS IN THE REGULATION OF HEART RATE.
Transplantation Journal
FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
Nature immunology
Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope.
The American journal of pathology
Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells.
Journal of immunology (Baltimore, Md. : 1950)
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.
Immunity
Chapter 14 Dynamics of B Cell Migration to and within Secondary Lymphoid Organs.
Molecular Biology of B Cells
Lymphoid organ development and cell migration.
Immunological reviews
Homing of antibody secreting cells.
Immunological reviews
Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.
The Journal of experimental medicine
Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development.
The Journal of experimental medicine
Integrin-dependence of lymphocyte entry into the splenic white pulp.
The Journal of experimental medicine
Erratum: Langerhans cells renew in the skin throughout life under steady-state conditions.
Nature immunology
The CDM protein DOCK2 in lymphocyte migration.
Trends in cell biology
Integrin-mediated long-term B cell retention in the splenic marginal zone.
Science (New York, N.Y.)
Chemokine requirements for B cell entry to lymph nodes and Peyer's patches.
The Journal of experimental medicine
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.
Journal of immunology (Baltimore, Md. : 1950)
B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950)
Chemorepulsion and thymocyte emigration.
The Journal of clinical investigation
CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity.
Immunity
Traffic patterns of B cells and plasma cells.
Advances in experimental medicine and biology
Splenic T zone development is B cell dependent.
The Journal of experimental medicine
A coordinated change in chemokine responsiveness guides plasma cell movements.
The Journal of experimental medicine
Chemokines in lymphopoiesis and lymphoid organ development.
Current opinion in immunology
Chemokines as regulators of T cell differentiation.
Nature immunology
Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.
Proceedings of the National Academy of Sciences of the United States of America
A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
Nature immunology
Follicular stromal cells and lymphocyte homing to follicles.
Immunological reviews
B cells on the front line.
Nature immunology
RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines.
Journal of immunology (Baltimore, Md. : 1950)
Tumor necrosis factor: a master-regulator of leukocyte movement.
Immunology today
Leukocyte migration: scent of the T zone.
Current biology : CB
Chemokines and cell migration in secondary lymphoid organs.
Science (New York, N.Y.)
In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines.
The Journal of experimental medicine
Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells.
Science (New York, N.Y.)
Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs.
The Journal of experimental medicine
Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen.
The Journal of experimental medicine
Chemokines and B-cell homing to follicles.
Current topics in microbiology and immunology
Follicular exclusion and rapid elimination of hen egg lysozyme autoantigen-binding B cells are dependent on competitor B cells, but not on T cells.
Journal of immunology (Baltimore, Md. : 1950)
Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.
Current topics in microbiology and immunology
Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice.
The Journal of experimental medicine
Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells.
The Journal of experimental medicine
Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells.
The Journal of experimental medicine
A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.
Nature
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment.
Immunity
Lymphocyte homing: the scent of a follicle.
Current biology : CB
Signaling thresholds and interclonal competition in preimmune B-cell selection.
Immunological reviews
The regulation of self-reactive B cells.
Current opinion in immunology
Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords.
The Journal of experimental medicine
Self-tolerance checkpoints in B lymphocyte development.
Advances in immunology
Antigenic determinants encoded by alternatively spliced exons of CD45 are determined by the polypeptide but influenced by glycosylation.
International immunology
Structural analysis of the CD2 T lymphocyte antigen by site-directed mutagenesis to introduce a disulphide bond into domain 1.
Protein engineering
Structure-function studies of CD2 by n.m.r. and mutagenesis.
Biochemical Society Transactions
Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2.
The Journal of experimental medicine
The NH2-terminal domain of rat CD2 binds rat CD48 with a low affinity and binding does not require glycosylation of CD2.
European journal of immunology
The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies.
European journal of immunology
IgE and IgG binding of peptides expressed from fragments of cDNA encoding the major house dust mite allergen Der p I.
Journal of immunology (Baltimore, Md. : 1950)