
Professor
Neurological Surgery
+1 415 514-2347
Arturo Alvarez-Buylla, PhD studies the origin, migration and functional contribution of neural stem cells born in the adult brain. He has initiated studies exploring progenitor cell transplants for the treatment of Parkinson’s disease and epilepsy.
Publications
Neural stem cell relay from B1 to B2 cells in the adult mouse ventricular-subventricular zone.
Cell reports
Integration of Transplanted Interneurons Over a New Period of Ocular Dominance Plasticity in Adult Visual Cortex.
bioRxiv : the preprint server for biology
Molecular and cellular dynamics of the developing human neocortex at single-cell resolution.
bioRxiv : the preprint server for biology
Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone.
bioRxiv : the preprint server for biology
The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.
Proceedings of the National Academy of Sciences of the United States of America
Developmental origin and local signals cooperate to determine septal astrocyte identity.
bioRxiv : the preprint server for biology
Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy.
Cell stem cell
Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis.
bioRxiv : the preprint server for biology
The Clustered Gamma Protocadherin Pcdh?c4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex.
bioRxiv : the preprint server for biology
Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".
Science (New York, N.Y.)
Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
Science (New York, N.Y.)
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1.
Science (New York, N.Y.)
Transplanted Cells Are Essential for the Induction But Not the Expression of Cortical Plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Immature excitatory neurons develop during adolescence in the human amygdala.
Nature communications
Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.
Cell reports
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain.
Development (Cambridge, England)
Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.
Neuron
Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Does Adult Neurogenesis Persist in the Human Hippocampus?
Cell stem cell
A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.
Nature cell biology
Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
Cerebral cortex (New York, N.Y. : 1991)
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
Cerebral cortex (New York, N.Y. : 1991)
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Cancer cell
Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.
Cell reports
Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells.
Stem cell reports
Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.
Cell reports
Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment.
Journal of neurophysiology
Transplantation of GABAergic interneurons for cell-based therapy.
Progress in brain research
Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories.
Nature communications
Extensive migration of young neurons into the infant human frontal lobe.
Science (New York, N.Y.)
Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium.
Trends in neurosciences
Identification of proliferative progenitors associated with prominent postnatal growth of the pons.
Nature communications
The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.
Cold Spring Harbor perspectives in biology
Brain size and limits to adult neurogenesis.
The Journal of comparative neurology
A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain.
Stem cell reports
Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies.
Journal of visualized experiments : JoVE
Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons.
Proceedings of the National Academy of Sciences of the United States of America
Postnatal growth of the human pons: a morphometric and immunohistochemical analysis.
The Journal of comparative neurology
Astrocyte development and heterogeneity.
Cold Spring Harbor perspectives in biology
Adult neural stem cells stake their ground.
Trends in neurosciences
Yoshiki Sasai (1962-2014).
Nature
Primary cilia are required in a unique subpopulation of neural progenitors.
Proceedings of the National Academy of Sciences of the United States of America
Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with A� accumulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Restricted nature of adult neural stem cells: re-evaluation of their potential for brain repair.
Frontiers in neuroscience
The adult macaque spinal cord central canal zone contains proliferative cells and closely resembles the human.
The Journal of comparative neurology
Interneurons from embryonic development to cell-based therapy.
Science (New York, N.Y.)
Axonal control of the adult neural stem cell niche.
Cell stem cell
Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.
Neurogenesis (Austin, Tex.)
Molecular diversity subdivides the adult forebrain neural stem cell population.
Stem cells (Dayton, Ohio)
Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.
Nature neuroscience
Neocortical integration of transplanted GABA progenitor cells from wild type and GABA(B) receptor knockout mouse donors.
Neuroscience letters
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences.
Nature neuroscience
Myb promotes centriole amplification and later steps of the multiciliogenesis program.
Development (Cambridge, England)
Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme.
Frontiers in oncology
Lineage progression from stem cells to new neurons in the adult brain ventricular-subventricular zone.
Cell cycle (Georgetown, Tex.)
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior.
Nature neuroscience
Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development.
Cell stem cell
Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice.
Proceedings of the National Academy of Sciences of the United States of America
Stem cells in the land of the rising sun: ISSCR 2012.
Cell stem cell
Biciliated ependymal cell proliferation contributes to spinal cord growth.
The Journal of comparative neurology
Sox1 marks an activated neural stem/progenitor cell in the hippocampus.
Development (Cambridge, England)
Regional astrocyte allocation regulates CNS synaptogenesis and repair.
Science (New York, N.Y.)
Adult neural stem cells bridge their niche.
Cell stem cell
Distinct patterns of human medulloblastoma dissemination in the developing chick embryo nervous system.
Clinical & experimental metastasis
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.
Neuron
Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain.
The Journal of comparative neurology
Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor.
Brain research reviews
New neurons clear the path of astrocytic processes for their rapid migration in the adult brain.
Neuron
The subventricular zone en-face: wholemount staining and ependymal flow.
Journal of visualized experiments : JoVE
Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats.
Cell stem cell
Cortical plasticity induced by inhibitory neuron transplantation.
Science (New York, N.Y.)
Cilia organize ependymal planar polarity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Role of primary cilia in brain development and cancer.
Current opinion in neurobiology
Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.
Cell stem cell
Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.
The EMBO journal
Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America
Epidermal growth factor induces the progeny of subventricular zone type B cells to migrate and differentiate into oligodendrocytes.
Stem cells (Dayton, Ohio)
Radiation damage increases Purkinje neuron heterokaryons in neonatal cerebellum.
Annals of neurology
Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
Nature
Identification and characterization of neural progenitor cells in the adult mammalian brain.
Advances in anatomy, embryology, and cell biology
The glial nature of embryonic and adult neural stem cells.
Annual review of neuroscience
Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The heterogeneity of adult neural stem cells and the emerging complexity of their niche.
Cold Spring Harbor symposia on quantitative biology
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.
Cell stem cell
Origin and function of olfactory bulb interneuron diversity.
Trends in neurosciences
Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool.
Developmental biology
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells.
Nature neuroscience
Characterization of adult neural stem cells and their relation to brain tumors.
Cells, tissues, organs
Developing cell transplantation for temporal lobe epilepsy.
Neurosurgical focus
Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension".
Science (New York, N.Y.)
Cells in the astroglial lineage are neural stem cells.
Cell and tissue research
Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone.
Stem cells (Dayton, Ohio)
Mosaic organization of neural stem cells in the adult brain.
Science (New York, N.Y.)
A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The adult neural stem cell niche: lessons for future neural cell replacement strategies.
Neurosurgery clinics of North America
Neural stem cells in mammalian development.
Current opinion in cell biology
Origin of oligodendrocytes in the subventricular zone of the adult brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Composition and organization of the SCZ: a large germinal layer containing neural stem cells in the adult mammalian brain.
Cerebral cortex (New York, N.Y. : 1991)
Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells.
Developmental biology
Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells.
The Journal of comparative neurology
New neurons follow the flow of cerebrospinal fluid in the adult brain.
Science (New York, N.Y.)
In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis.
Molecular and cellular neurosciences
Neural stem cells and the origin of gliomas.
The New England journal of medicine
Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.
Development (Cambridge, England)
Radial glia give rise to adult neural stem cells in the subventricular zone.
Proceedings of the National Academy of Sciences of the United States of America
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus.
The Journal of comparative neurology
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration.
Nature
Telomerase activity in the subventricular zone of adult mice.
Molecular and cellular neurosciences
Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment.
Cerebral cortex (New York, N.Y. : 1991)
Becoming a new neuron in the adult olfactory bulb.
Nature neuroscience
Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.
Proceedings of the National Academy of Sciences of the United States of America
Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neural stem cells and the regulation of neurogenesis in the adult hippocampus.
Clinical neuroscience research
Identification of neural stem cells in the adult vertebrate brain.
Brain research bulletin
Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurogenesis in adult subventricular zone.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents.
The Journal of neuroscience : the official journal of the Society for Neuroscience
In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain.
Development (Cambridge, England)
Astrocytes give rise to new neurons in the adult mammalian hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Unsupervised learning and adaptation in a model of adult neurogenesis.
Journal of computational neuroscience
A unified hypothesis on the lineage of neural stem cells.
Nature reviews. Neuroscience
Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone.
Nature neuroscience
The subventricular zone: source of neuronal precursors for brain repair.
Progress in brain research
Adult-derived neural precursors transplanted into multiple regions in the adult brain.
Annals of neurology
Regeneration of a germinal layer in the adult mammalian brain.
Proceedings of the National Academy of Sciences of the United States of America
Fate of new neurons in adult canary high vocal center during the first 30 days after their formation.
The Journal of comparative neurology
Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Young neurons from medial ganglionic eminence disperse in adult and embryonic brain.
Nature neuroscience
Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Stem cells in the adult mammalian central nervous system.
Current opinion in neurobiology
Architecture and cell types of the adult subventricular zone: in search of the stem cells.
Journal of neurobiology
Stem cells in the developing and adult nervous system.
Journal of neurobiology
Primary neural precursors and intermitotic nuclear migration in the ventricular zone of adult canaries.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis.
Proceedings of the National Academy of Sciences of the United States of America
Birth, migration, incorporation, and death of vocal control neurons in adult songbirds.
Journal of neurobiology
Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mechanism of migration of olfactory bulb interneurons.
Seminars in cell & developmental biology
Neurogenesis in juvenile and adult ring doves.
The Journal of comparative neurology
Network of tangential pathways for neuronal migration in adult mammalian brain.
Proceedings of the National Academy of Sciences of the United States of America
Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain.
Proceedings of the National Academy of Sciences of the United States of America
Chain migration of neuronal precursors.
Science (New York, N.Y.)
Neuronal stem cells in the brain of adult vertebrates.
Stem cells (Dayton, Ohio)
Embryonic (PSA) N-CAM reveals chains of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice.
The Journal of comparative neurology
Contribution of neurons born during embryonic, juvenile, and adult life to the brain of adult canaries: regional specificity and delayed birth of neurons in the song-control nuclei.
The Journal of comparative neurology
Testosterone increases the recruitment and/or survival of new high vocal center neurons in adult female canaries.
Proceedings of the National Academy of Sciences of the United States of America
The life span of new neurons in a song control nucleus of the adult canary brain depends on time of year when these cells are born.
Proceedings of the National Academy of Sciences of the United States of America
Long-distance neuronal migration in the adult mammalian brain.
Science (New York, N.Y.)
Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.
Proceedings of the National Academy of Sciences of the United States of America
High vocal center growth and its relation to neurogenesis, neuronal replacement and song acquisition in juvenile canaries.
Journal of neurobiology
Neurogenesis and plasticity in the CNS of adult birds.
Experimental neurology
Production and survival of projection neurons in a forebrain vocal center of adult male canaries.
The Journal of neuroscience : the official journal of the Society for Neuroscience
On variables that affect estimates of the true sizes and densities of radioactively labeled cell nuclei.
The Journal of comparative neurology
Birth of projection neurons in adult avian brain may be related to perceptual or motor learning.
Science (New York, N.Y.)
Mechanism of neurogenesis in adult avian brain.
Experientia
Song learning in birds: the relation between perception and production.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Cresyl violet: a red fluorescent Nissl stain.
Journal of neuroscience methods
Expression of the yes proto-oncogene in cerebellar Purkinje cells.
Molecular and cellular biology
In situ hybridization using PEG-embedded tissue and riboprobes: increased cellular detail coupled with high sensitivity.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Birth of projection neurons in the higher vocal center of the canary forebrain before, during, and after song learning.
Proceedings of the National Academy of Sciences of the United States of America
Simple microcomputer system for mapping tissue sections with the light microscope.
Journal of neuroscience methods
Mapping of radial glia and of a new cell type in adult canary brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Differential developmental expression of cellular yes and cellular src proteins in cerebellum.
Oncogene research
Monoclonal antibody reveals radial glia in adult avian brain.
The Journal of comparative neurology
Characterization of alkaline phosphatase from primordial germ cells and ontogenesis of this enzyme in the mouse.
Differentiation; research in biological diversity