
Professor
Urology
+1 415 476-2838
Robert Blelloch, MD, PhD studies gene regulation of pluripotent stem cells, early development, and cancer.
Publications
The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells.
Stem cells (Dayton, Ohio)
The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells.
bioRxiv : the preprint server for biology
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.
Cancer immunology research
MLL3/MLL4 enzymatic activity shapes DNA replication timing.
bioRxiv : the preprint server for biology
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.
Nature structural & molecular biology
G1/S restriction point coordinates phasic gene expression and cell differentiation.
Nature communications
Beyond Maternal Tolerance: Education of Uterine Natural Killer Cells by Maternal MHC Drives Fetal Growth.
Frontiers in immunology
The roles of microRNAs in mouse development.
Nature reviews. Genetics
MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.
Proceedings of the National Academy of Sciences of the United States of America
LIN28B Impairs the Transition of hESC-Derived � Cells from the Juvenile to Adult State.
Stem cell reports
Epigenetic control of transcriptional regulation in pluripotency and early differentiation.
Development (Cambridge, England)
High-throughput, Efficient, and Unbiased Capture of Small RNAs from Low-input Samples for Sequencing.
Scientific reports
FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
Cell stem cell
GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency.
Cell stem cell
Expression of Alternative Ago2 Isoform Associated with Loss of microRNA-Driven Translational Repression in Mouse Oocytes.
Current biology : CB
The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport.
Development (Cambridge, England)
NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.
RNA (New York, N.Y.)
Patterning of sharp cellular interfaces with a reconfigurable elastic substrate.
Integrative biology : quantitative biosciences from nano to macro
The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells.
Nature communications
Vitamin C and l-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum.
Stem cell reports
miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B�Cell Maturation.
Cell reports
A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates.
Stem cells (Dayton, Ohio)
FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
Cell stem cell
Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
Current biology : CB
Biogenesis, delivery, and function of extracellular RNA.
Journal of extracellular vesicles
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.
Cell reports
Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.
The EMBO journal
CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Stem cell reports
Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
Osteoarthritis and Cartilage
Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.
Cell death and differentiation
Regulation of pluripotency by RNA binding proteins.
Cell stem cell
Regulation of microRNA function in somatic stem cell proliferation and differentiation.
Nature reviews. Molecular cell biology
MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells.
Nature structural & molecular biology
Epigenetics of cellular reprogramming.
Current opinion in genetics & development
microRNA control of mouse and human pluripotent stem cell behavior.
Annual review of cell and developmental biology
Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions.
Current opinion in cell biology
Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.
Current opinion in cell biology
Small RNAs in germline development.
Current topics in developmental biology
An integrated nano-scale approach to profile miRNAs in limited clinical samples.
American journal of clinical and experimental immunology
Sox1 marks an activated neural stem/progenitor cell in the hippocampus.
Development (Cambridge, England)
Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
Molecular and cellular neurosciences
Efficiency and specificity in microRNA biogenesis.
Nature structural & molecular biology
microRNA induced transdifferentiation.
F1000 biology reports
Dgcr8 controls neural crest cells survival in cardiovascular development.
Developmental biology
MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells.
Immunity
High throughput microRNA profiling: optimized multiplex qRT-PCR at nanoliter scale on the fluidigm dynamic arrayTM IFCs.
Journal of visualized experiments : JoVE
A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.
RNA (New York, N.Y.)
From microRNAs to targets: pathway discovery in cell fate transitions.
Current opinion in genetics & development
Small RNAs in early mammalian development: from gametes to gastrulation.
Development (Cambridge, England)
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.
Nature biotechnology
Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.
Neural development
Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Genes & development
Cell cycle regulation by microRNAs in stem cells.
Results and problems in cell differentiation
Microfluidic-based multiplex qRT-PCR identifies diagnostic and prognostic microRNA signatures in the sera of prostate cancer patients.
Cancer research
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
Nature medicine
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.
Cancer research
Distinct requirements of microRNAs in NK cell activation, survival, and function.
Journal of immunology (Baltimore, Md. : 1950)
MicroRNAs control hepatocyte proliferation during liver regeneration.
Hepatology (Baltimore, Md.)
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.
Genes & development
MicroRNA function is globally suppressed in mouse oocytes and early embryos.
Current biology : CB
MicroRNA Regulation of Embryonic Stem Cell Self-Renewal and Differentiation.
Advances in experimental medicine and biology
Watching reprogramming in real time.
Nature biotechnology
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.
Circulation research
Cell cycle regulation by MicroRNAs in embryonic stem cells.
Cancer research
Embryonic stem cell-specific microRNAs promote induced pluripotency.
Nature biotechnology
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation.
Nature genetics
CompMoby: comparative MobyDick for detection of cis-regulatory motifs.
BMC bioinformatics
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.
Genes & development
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Nature genetics
Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus.
Stem cells (Dayton, Ohio)
Nuclear cloning of embryonal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America
TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.
Development (Cambridge, England)
Reprogramming of a melanoma genome by nuclear transplantation.
Genes & development
Nuclear cloning, epigenetic reprogramming, and cellular differentiation.
Cold Spring Harbor symposia on quantitative biology
Nuclear transplantation, embryonic stem cells and the potential for cell therapy.
The hematology journal : the official journal of the European Haematology Association
The gon-1 gene is required for gonadal morphogenesis in Caenorhabditis elegans.
Developmental biology
Control of cell migration during Caenorhabditis elegans development.
Current opinion in cell biology
A molecular genetic model of human bladder cancer pathogenesis.
Seminars in oncology