Assistant Professor
Pathology
My research focuses on gene regulatory networks in human tissues, leveraging single-cell and spatial assays combined with innovative computational methods. I've significantly contributed to the Encyclopedia of DNA Elements (ENCODE) project through RNA-centric approaches, and to the Human Cell Atlas (HCA) with a focus on developing limbs and lungs.
My interdisciplinary research group is dedicated to developing computational methods and profiling transcriptomic and chromatin changes. We aim to construct ultra-high resolution cell atlases of healthy and altered tissues and organoids, to dissect the intricate relationships between genes, cells and tissues.
Publications
Single-cell transcriptomics identifies chondrocyte differentiation dynamics in vivo and in vitro.
Developmental cell
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease.
The EMBO journal
A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast.
Nature genetics
A spatially resolved atlas of the human lung characterizes a gland-associated immune niche.
Nature genetics
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease.
Cell stem cell
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.
The EMBO journal
Mapping the developing human immune system across organs.
Science (New York, N.Y.)
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Nature medicine
Perspectives on ENCODE.
Nature