
Assistant Professor
Orthopaedic Surgery
Kelsey Collins, PhD, uses induced pluripotent stem cells, CRISPR-Cas9 genome engineering, mouse models, human tissues, and state-of-the-art multi-omic spatial approaches to define mechanisms and create therapies that have implications for aging, obesity, diabetes, and other chronic diseases.
Publications
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain.
Science advances
Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery.
Arthritis research & therapy
Independent and combined effects of obesity and traumatic joint injury to the structure and composition of rat knee cartilage.
Connective tissue research
Evolution and advancements in genomics and epigenomics in OA research: How far we have come.
Osteoarthritis and Cartilage
Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies.
Osteoarthritis and Cartilage
Post or perish? Social media strategies for disseminating orthopedic research.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy.
Gels (Basel, Switzerland)
The role of PIEZO ion channels in the musculoskeletal system.
American journal of physiology. Cell physiology
Trimming the fat - is leptin crosstalk the link between obesity and osteoarthritis?
Osteoarthritis and Cartilage
Leptin mediates the regulation of muscle mass and strength by adipose tissue.
The Journal of physiology
A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery.
Science advances
Taxonomic changes in the gut microbiota are associated with cartilage damage independent of adiposity, high fat diet, and joint injury.
Scientific reports
Contractility of permeabilized rat vastus intermedius muscle fibres following high-fat, high-sucrose diet consumption.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Immunoengineering the next generation of arthritis therapies.
Acta biomaterialia
Adipose tissue is a critical regulator of osteoarthritis.
Proceedings of the National Academy of Sciences of the United States of America
Is Obesity a Disease of Stem Cells?
Cell stem cell
Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction.
The Journal of physiology
Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity.
Science advances
The role of macrophages in osteoarthritis and cartilage repair.
Osteoarthritis and Cartilage
Impact of age on host responses to diet-induced obesity: Development of joint damage and metabolic set points.
Journal of sport and health science
Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity.
Scientific reports
Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury.
Precision nanomedicine
Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs.
Tissue engineering and regenerative medicine
High-fat/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model.
Bone & joint research
Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity.
Frontiers in physiology
Potential Impact of Metabolic and Gut Microbial Response to Pregnancy and Lactation in Lean and Diet-Induced Obese Rats on Offspring Obesity Risk.
Molecular nutrition & food research
Diet-induced obesity leads to pro-inflammatory alterations to the vitreous humour of the eye in a rat model.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Acute and chronic changes in rat soleus muscle after high-fat high-sucrose diet.
Physiological reports
Association of body mass index (BMI) and percent body fat among BMI-defined non-obese middle-aged individuals: Insights from a population-based Canadian sample.
Canadian journal of public health = Revue canadienne de sante publique
A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats.
Scientific reports
Reduced knee adduction moments for management of knee osteoarthritis:: A three month phase I/II randomized controlled trial.
Gait & posture
High-fat high-sucrose diet leads to dynamic structural and inflammatory alterations in the rat vastus lateralis muscle.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model.
Osteoarthritis and Cartilage
Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats.
Osteoarthritis and Cartilage