
Professor
Cell and Tissue Biology
+1 415 476-9459
Jeff Bush, PhD studies signaling during normal craniofacial development and in cases of craniofacial birth defects with the goal of developing preventive therapies.
Publications
Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest.
bioRxiv : the preprint server for biology
Alternative cleavage and polyadenylation of the Ccnb1 mRNA defines accumulation of cyclin protein during the meiotic cell cycle.
Nucleic acids research
A Suite of Mouse Reagents for Studying Amelogenesis.
bioRxiv : the preprint server for biology
Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus.
American journal of medical genetics. Part A
A unique form of collective epithelial migration is crucial for tissue fusion in the secondary palate and can overcome loss of epithelial apoptosis.
Development (Cambridge, England)
Investigating Cell Fate Specification upon Nkx2-1Loss.
The FASEB Journal
Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting.
Cell reports
Cellular and molecular mechanisms of EPH/EPHRIN signaling in evolution and development.
Current topics in developmental biology
Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.
Developmental dynamics : an official publication of the American Association of Anatomists
EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.
The Journal of cell biology
Cellular and Molecular Regulation of Upper Lip Fusion.
The FASEB Journal
Effects of EPHB receptors on facial morphology: non-additive interactions during mouse facial development.
The FASEB Journal
Separation of the trachea and esophagus is coupled to identity specification by NKX2-1-mediated regulation of EPH/EPHRIN signaling and cell sorting.
The FASEB Journal
YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate.
Journal of dental research
Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis.
Current opinion in cell biology
The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community.
G3 (Bethesda, Md.)
Morphometric Analysis of Efnb1 Dependent Palate Growth.
The FASEB Journal
Hypertelorism of Efnb1 Null Mice Occurs Independently of Changes to Underlying Brain Shape.
The FASEB Journal
Cellular organization and boundary formation in craniofacial development.
Genesis (New York, N.Y. : 2000)
WITHDRAWN: Editorial Introduction.
Developmental biology
Editorial: Signaling pathways instruct the blueprint of life.
Developmental biology
Getting direction(s): The Eph/ephrin signaling system in cell positioning.
Developmental biology
Live Imaging of Mouse Secondary Palate Fusion.
Journal of visualized experiments : JoVE
Cellular dynamics of tissue fusion in craniofacial development and orofacial clefting.
The FASEB Journal
EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.
Stem cell reports
Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.
The Journal of cell biology
From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models.
Current topics in developmental biology
Neural crest defects in ephrin-B2 mutant mice are non-autonomous and originate from defects in the vasculature.
Developmental biology
Convergence and extrusion are required for normal fusion of the mammalian secondary palate.
PLoS biology
Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.
Developmental dynamics : an official publication of the American Association of Anatomists
Cell intercalation and migration mediated by actin contractility are key cellular behaviors in fusion of the mammalian secondary palate (344.2).
The FASEB Journal
The society of craniofacial genetics and developmental biology 35th annual meeting.
American Journal of Medical Genetics Part A
The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling.
Developmental biology
Ephrin B1 maintains apical adhesion of neural progenitors.
Development (Cambridge, England)
Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development.
Development (Cambridge, England)
Eph/ephrin signaling: genetic, phosphoproteomic, and transcriptomic approaches.
Seminars in cell & developmental biology
Ephrin-B signaling in craniofacial development and disease.
The FASEB Journal
Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries.
Genes & development
Analysis of signaling downstream of ephrin-B1 during development.
Developmental biology
Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism.
Genes & development
The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival.
Genesis (New York, N.Y. : 2000)
Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome.
PLoS biology
Development of the upper lip: Morphogenetic and molecular mechanisms.
Developmental Dynamics
Development of the upper lip: morphogenetic and molecular mechanisms.
Developmental dynamics : an official publication of the American Association of Anatomists
Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.
Developmental dynamics : an official publication of the American Association of Anatomists
The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.
Proceedings of the National Academy of Sciences of the United States of America
The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis.
Gene expression patterns : GEP
Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene.
Developmental dynamics : an official publication of the American Association of Anatomists