Assistant Professor
Neurology
Claire Clelland, MD, PhD, MPhil aims to develop novel therapies for dementia and related neurodegenerative diseases. Her lab works to create new CRISPR gene editing approaches in human iPSC-derived cell types relevant to disease. They also work to build cell model systems that more faithfully replicate human disease.
Publications
Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.
bioRxiv : the preprint server for biology
Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery.
bioRxiv : the preprint server for biology
Measurement and clinical interpretation of CRISPR off-targets.
Nature genetics
PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation.
bioRxiv : the preprint server for biology
Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.
Communications biology
Discovery research in physiologically maintained deceased.
Science (New York, N.Y.)
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference.
Alzheimer's & dementia : the journal of the Alzheimer's Association
nf-core/pacvar: a pipeline for analyzing long-read PacBio whole genome and repeat expansion sequencing data.
Bioinformatics (Oxford, England)
Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.
Proceedings of the National Academy of Sciences of the United States of America
Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.
Proceedings of the National Academy of Sciences of the United States of America
Validated assays for the quantification of C9orf72 human pathology.
Scientific reports
Novel avenues of tau research.
Alzheimer's & dementia : the journal of the Alzheimer's Association
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience
Microglial microRNAs mediate sex-specific responses to tau pathology.
Nature neuroscience
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease.
Neurobiology of disease
Common cerebral networks associated with distinct deep brain stimulation targets for cluster headache.
Cephalalgia : an international journal of headache
Comprehensive review of stereotactic radiosurgery for medically and surgically refractory pituitary adenomas.
Surgical neurology international
A functional role for adult hippocampal neurogenesis in spatial pattern separation.
Science (New York, N.Y.)
Cell therapy in Huntington disease.
Neurosurgical focus