
Associate Professor
Neurological Surgery
+1 415 502-5498
Michael C. Oldham, PhD studies the organization of the transcriptome in the developing and adult human brain, and how this organization differs among primate species and brains affected by disease.
Publications
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Nature neuroscience
Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections.
bioRxiv : the preprint server for biology
EPCO-39. CLARIFYING THE MOLECULAR CONSEQUENCES OF ONCOGENIC MUTATIONS THROUGH MULTISCALE AND MULTIOMIC ANALYSIS OF INDIVIDUAL TUMORS.
Neuro-oncology
Generation of functional human oligodendrocytes from dermal fibroblasts by direct lineage conversion.
Development (Cambridge, England)
Abstract 3621: 3D spatial sampling and integrated omics reveal sources and patterning of intratumoral heterogeneity in glioblastoma.
Cancer research
Nests of dividing neuroblasts sustain interneuron production for the developing human brain.
Science (New York, N.Y.)
ECOA-5. Integrative 3D spatial characterization of genomic and epigenomic intratumoral heterogeneity in glioblastoma.
Neuro-oncology advances
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
The Journal of clinical investigation
Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Diagnostic blood RNA profiles for human acute spinal cord injury.
The Journal of experimental medicine
Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.
Scientific reports
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module.
Nature neuroscience
MicroRNA Ratios Distinguish Melanomas from Nevi.
The Journal of investigative dermatology
Immunopeptidomics and Peptide Expression Profiles to Develop T-Cell Receptors Against Glioma-Associated Antigens.
Neurosurgery
786 A machine-learning classifier trained with microRNA ratios to distinguish melanomas from nevi.
Journal of Investigative Dermatology
Does Adult Neurogenesis Persist in the Human Hippocampus?
Cell stem cell
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes.
Nature neuroscience
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.
Cerebral cortex (New York, N.Y. : 1991)
1220 MicroRNA signature distinguishing nevi from primary melanoma.
Journal of Investigative Dermatology
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Cancer cell
IMMU-52. SELECTION OF GLIOMA T-CELL THERAPY TARGETS BASED ON THE ANALYSIS OF TUMOR IMMUNOPEPTIDOME AND EXPRESSION PROFILES.
Neuro-oncology
Genetic Characterization of Stromal Cells in High Grade Gliomas.
International Journal of Radiation Oncology • Biology • Physics
Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis.
eLife
GENT-15. INTEGRATED MOLECULAR PROFILING OF HUMAN BRAIN TUMORS THROUGH MULTIOMIC ANALYSIS OF SERIAL SECTIONS (MASS).
Neuro-oncology
Transcriptional architecture of the human brain.
Nature neuroscience
MPTH-29CONNECTING MUTANT GENOTYPES TO ABERRANT TRANSCRIPTIONAL SIGNATURES ACROSS SERIAL SECTIONS OF A HUMAN TUMOR.
Neuro-oncology
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability.
Cell reports
DISTINCT AND SEPARABLE ROLES FOR HISTONE METHYLTRANSFERASE EZH2 IN NEUROGENIC ASTROCYTES.
Neuro-oncology
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
The Journal of clinical investigation
Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.
Cell stem cell
Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.
Genes & development
Network methods for describing sample relationships in genomic datasets: application to Huntington's disease.
BMC systems biology
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons.
Genome research
Is my network module preserved and reproducible?
PLoS computational biology
The organization of the transcriptional network in specific neuronal classes.
Molecular systems biology
Gene Expression in the Evolution of the Human Brain.
Encyclopedia of Neuroscience
Functional organization of the transcriptome in human brain.
Nature neuroscience
A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Genome-wide analyses of human perisylvian cerebral cortical patterning.
Proceedings of the National Academy of Sciences of the United States of America
Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.
American journal of human genetics
Conservation and evolution of gene coexpression networks in human and chimpanzee brains.
Proceedings of the National Academy of Sciences of the United States of America
Deconstructing language by comparative gene expression: from neurobiology to microarray.
Genes, brain, and behavior
Evolutionary genetics: the human brain -- adaptation at many levels.
European journal of human genetics : EJHG
Human brain evolution: insights from microarrays.
Nature reviews. Genetics