Valerie Weaver, PhD


Dr. Weaver's research focuses on several areas: (1) The role of physical force in human embryonic stem cell fate. (2) The molecular mechanism linked to JNK and SMRT pathways whereby alpha 6/beta 4 integrin activates RAC and NFkappa B to mediate apoptosis resistance in reconstituted basement generated MEC tissue structures in culture and in a transgenic mouse model. (3) The role of physical force and tissue architecture in culture and in transgenic models and clinically in the pathogenesis of therapy resistant breast cancers.