Geoffrey Manley, MD, PhD


The mission of the UCSF Brain and Spinal Injury Center (BASIC) is to promote collaborative basic, translational and clinical studies on injuries to the brain and spinal cord. BASIC is located at San Francisco General Hospital, an internationally recognized Trauma Center. The clinical research program addresses acute care and rehabilitation for brain and spinal cord injured patients. The translational research program emphasizes experimental model development and the application of these models to address clinically relevant problems. Most importantly, the main objective of BASIC is to establish a pipeline directly linking translational and clinical programs. This bench to bedside concept is intended to bridge the gap between what is developed in the laboratory and how it might be applied in the clinical setting to achieve functional repair and recovery of the injured brain and spinal cord. We are currently in the planning phase of developing a clinical stem cell program for the treatment of spinal cord injury. The specific aim is to evaluate the potential of human adult stem cells (olfactory ensheathing glial cells) obtained from the patients themselves (via nasal biopsy) to promote regeneration and functional recovery. Clinical and translational studies on the potential of stem cell transplants for traumatic brain injury are being considered as well.