Jacquelyn Maher, MD


My laboratory studies basic mechanisms of hepatotoxicity, with a focus on clinically relevant diseases such as drug-induced liver injury and nonalcoholic steatohepatitis (NASH). One important goal is to identify hepatoprotective compounds that are therapeutic in the setting of acute liver failure or liver transplantation. In the setting of fatty liver, we are interested in the ability of specific fatty acids to cause liver cell death (“lipotoxicity”). We use cell culture and animal models to investigate how fat causes liver injury, and how the accumulation of toxic fatty acids in the liver might be avoided by dietary modifications such as lowering sugar consumption.