Pamela Den Besten, DDS


Our laboratory has successfully grown dental pulp stem cells from human primary (decidous) and permanent teeth. We are also able to isolate pulp stem cells from developing mouse molars. We have used these cells to direct differentiation of human ameloblasts from precursor cells isolated from fetal material. I believe this is a unique and promising field of research that will have a tremendous impact on individuals affected by tooth loss, as well as providing a general model to enhance our knowledge of organ regeneration.