Jayanta Debnath, MD


My laboratory wishes to understand the role and regulation of autophagy in epithelial homeostasis and cancer pathogenesis. Autophagy is a genetically-controlled catabolic process through which a cell “eats itself” during times of stress or starvation. Autophagy has important therapeutic implications for numerous human diseases, including cancer, yet how this fundamental process influences cancer progression remains unclear. Using in vitro and in vivo approaches, our goals are to investigate the role and regulation of autophagy in:

  1. Epithelial cell fate and oncogenic transformation
  2. Chemotherapeutic response in cancer cells
  3. Tissue homeostasis and tumor formation