Guo Huang, PhD

Affiliated

The regenerative potential in the animal kingdom displays striking divergence across ontogeny and phylogeny. For example, heart regeneration is remarkably robust in adult zebrafish and newborn mice while very limited in adult mammals. This presents a particular problem for patients with a heart attack who suffer from loss of millions of heart muscle cells and life-threatening functional deterioration of the heart.

We use the heart as a model to study organ regeneration and repair in adult zebrafish, neonatal and adult mice, with an emphasis on the pathways that regulate resident stem cell activation and cardiac muscle cell proliferation, and with innovative and integrated approaches in engineering, single cell analysis, advanced imaging microscopy and genome manipulation technology.

Complete Publications

Huang, G. N., Thatcher, J. E., McAnally, J., Kong, Y., Qi, X., Tan, W., DiMaio, M., Amatruda, J. F., Gerrard, G., Hill, J. A., Bassel-Duby, R. & Olson, E. N. (2012) C/EBP transcription factors mediate epicardial activation during heart development and injury. Science (Research Article). 338 (6114): 1599-1603. PDF PubMed

Song, K., Nam, Y., Luo, X., Qi, X., Tan, W., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Nelson, E. G., Hill, J., Bassel-Duby, R. & Olson, E. N. (2012) Heart repair by expression of cardiac transcription factors in non-cardiomyocytes in vivo. Nature (Research Article). 485(7400):599-604. PubMed

Shim, S., Yuan, J. P., Kim, J. Y., Zeng, W., Huang, G., Milshteyn, A., Kern, D., Muallem, S., Ming, G. L., and Worley, P. F. (2009) Peptidyl-Prolyl Isomerase FKBP52 Controls Chemotropic Guidance of Neuronal Growth Cones via Regulation of TRPC1 Channel Opening. Neuron. 64(4):471-83.PubMed

Zeng, W., Yuan, J. P., Kim, M. S., Choi, Y. J., Huang, G. N., Worley, P. F. & Muallem S. (2008) STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell. 32(3):439-48.PubMed

Huang, G. N., Huso, D., Bouyain, S., Tu, J., McCorkell, K. A., May, M. J., Zhu Y., Lutz M., Collins S., Dehoff M., Kang S., Whartenby, K., Powell J., Leahy, D., and Worley, P. F. (2008) NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science.319 (5862): 476-81. PubMed

Yuan, J. P., Zeng, W., Huang, G. N., Worley, P. F. & Muallem S. (2007) STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nature Cell Biology.9(6):636-45. PubMed

Huang, G. N*., Zeng, W., Kim*, J. Y., Yuan, J.P., Han, L., Muallem, S. & Worley, P. F. (2006) STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nature Cell Biology.8(9): 1003-10. (*, equal contribution). PubMed