Linda Giudice, MD, PhD

Core

Our laboratory has had a long-standing interest in the role of normal and abnormal endometrial development and its relevance to implantation, miscarriage, fetal growth, and endometriosis in humans.

We study the roles of the insulin-like growth factor (IGF) system and the Wnt family in human endometrium, the role of the IGF system in human trophoblast invasion and function, and have numerous ongoing studies on functional genomics of human reproductive tissues.

We have pursued gene discovery in the window of implantation in endometrium from normal women and in women with endometrial disorders, including endometriosis, repetitive miscarriage, and unexplained infertility. We have also performed molecular profiling of human endometrium across the menstrual cycle and in these disease states. These studies have resulted in identification of markers of diseases of the endometrium and potential targets for therapies. These studies have given insight into basic biologic processes in these conditions and have identified molecular markers and for targeted diagnostics and therapeutics.

We study mechanisms underlying endometrial differentiation in response to steroid hormones and cross-talk between the placenta and the maternal decidua, as well as putative endometrial stem cells and their relevance to endometrial regeneration and benign and malignant endometrial disorders. Some of these studies have revealed extensive roles for components of the immune system in reproductive disorders, which we are actively pursuing in translational studies. We are also investigating hESC differentiation down the trophoblast lineage and interactions between the human trophectoderm with endometrial epithelium in a model of the initial stage of implantation in humans.