Faculty O-U

O

  • Michael C. Oldham, PhD studies the organization of the transcriptome in the developing and adult human brain, and how this organization differs among primate species and brains affected by disease.
  • Jeffrey Olgin, MD Director of the Adult Cardiac Electrophysiology Division, studies the cardiac conduction system and its coordination and integration with introduced stem cells.

P

  • Georgia Panagiotakos, PhD studies how electrical activity and calcium signaling regulate the differentiation of neural progenitor cells into specific neuronal subtypes in the context of both normal brain development and neurodevelopmental disorders.
  • Barbara Panning, PhD studies how RNA containing complexes modulate chromatin structure and gene expression.
  • Anders Persson, PhD Development and biology of brain tumors
  • Claudia Petritsch, PhD studies the molecular basis of asymmetrical cell division in neuronal stem and progenitor cells.
  • Samuel Pleasure, MD, PhD studies the development of the brain, in particular the mechanisms regulating cell proliferation, migration and axon guidance during prenatal development.
  • Alex Pollen, PhD studies the genomic basis for evolutionary specializations of the human brain with a focus on cortical development.
  • Jason Pomerantz, MD Mesenchymal tissue regeneration

R

  • Miguel Ramalho-Santos, PhD, MSc studies the genetic regulation of embryonic stem pluripotency and somatic cell reprogramming.
  • Katherine A. Rauen, MD, PhD studies germline mutations in genes associated with the Ras/mitogen-activated protein kinase (MAPK) pathway and the application of array CGH in clinical genetics.
  • Louis Reichardt, PhD studies neural cell fates in development.
  • Jeremy Reiter, MD, PhD focuses on identifying novel intercellular signals that direct the differentiation of embryonic stem cells along defined lineages.
  • Paolo Rinaudo, MD a clinical reproductive endocrinologist, studies the culture of mammalian embryos and potential consequences to long term health due to culture.
  • Jason Rock, PhD studies how resident epithelial and stromal cell populations of the lung are specified during development and how they maintain the organ over a lifetime.
  • Jeroen Roose, PhD studies Ras Signaling and lindeage Decision in Stem- and Progenitor- Cells
  • Steven Rosen, PhD studies the molecular mechanisms of lymphocyte homing to inflamed islets.
  • David H. Rowitch, MD, PhD is interested in brain tumor stem cells and disorders of white matter.
  • John Rubenstein, MD, PhD studies the molecular and cellular mechanisms of embryogenesis, and the genetic control of forebrain development. He explores the origin of inhibitory interneurons in the brain, and their possible utility in cell-based therapy for brain disorders such as epilepsy and Parkinson’s disease.
  • James Rubenstein, MD, PhD is working to define the molecular features of non-Hodgkin's lymphoma (NHL) of the central nervous system (CNS) using microarray technology.
  • Eric Rulifson, PhD studies the development of insulin producing cells using Drosophilia as model system. The insulin producing cells in Drosophilia represent a simple and ancestral organ representative of the pancreas in mammals.

S

  • Richard Schneider, PhD studies the development of neural crest, a mesenchymal cell population, and its role in patterning of the craniofacial organization.
  • Bjoern Schwer, MD, PhD is investigating molecular processes that affect genomic stability in developing and mature neural lineage cells and a role of such processes in development, aging, and cancers of the brain.
  • Neil Shah, MD, PhD is an expert in developing molecularly targeted therapies for chronic myeloid leukemia and other hematologic malignancies.
  • Robin Shaw, MD, PhD Regulation of Cardiac Ion Channels: Cytoskeleton and Membrane Targeting
  • Nirao Shah, MD, PhD studies how sex-specific behaviors, such as mating, nursing, and aggression are encoded by neural circuits
  • Kevin Shannon, MD studies signaling mechanisms that regulate the growth and differentiation of normal and leukemic stem cells. His laboratory is particularly interested in the genetic and biochemical basis of inherited leukemia predispositions and the regulation of growth of hematopoietic stem/progenitor cells by Ras signaling.
  • Shehua Shen, MD is a clinical embryologist who specializes in gamete and embryo micromanipulation and microinjection and advancement of laboratory IVF procedures.
  • Yin Shen, PhD Utilize genomics tools to investigate the genetic and epigenetic contributions to gene regulation in development and diseases.
  • Dean Sheppard, MD, PhD studies the role of integrins and signaling mechanisms in cell and tissue interactions in the lung, and specifically in lung injury and fibrosis.
  • Matthew Springer, PhD studies cell and gene therapies for ischemic diseases, to aid in tissue revascularization, preservation, and potentially regeneration. Other interests involve vascular endothelial function, including its response to diet and cigarette smoke exposure.
  • David Sretavan, MD, PhDstudies the cellular and molecular mechanisms that underlie the formation of retinal gan-glion cell axon projections, the major axon path-ways conveying visual information from the eyes to the CNS targets.
  • Deepak Srivastava, MD, PhD is the Director of the Gladstone Institute of Cardiovascular Disease and studies the causes of heart disease with a goal of using knowledge of the cardiac developmental pathways to devise novel therapeutics for human cardiac disorders.
  • Hua Su, MD studies gene and cell based therapies for cerebral vascular diseases, including stroke.

T

  • Thea Tlsty, PhD studies the identity and role of cancer stem cells in the development and progression of breast cancer. She also has a research program on the characterization of genomic instability in cancer initiation and progression.

U

  • Erik Ullian, PhD studies the cell extrinsic and intrinsic mechanisms that regulate synapse number and function, particularly the role of glial cells in regulating neuronal synapse formation and function.