Faculty H-N

H

  • Akiko Hata, PhD Mechanisms of growth factor signaling in the control of cell growth and differentiation of vascular cells
  • Matthias Hebrok, PhD studies how undifferentiated epithelial cells develop into functional endocrine cells, specifically insulin-producing beta-cells.
  • Michelle Hermiston, MD, PhD focuses on elucidating the impact of immune dysregulation on hematologic disease and translating these findings into clinical use.
  • Edward Hsiao, MD, PhD Hormonal and genetic regulation of human skeletal disease
  • Serena Hu, MD studies disc degeneration and its interaction with pain.
  • Eric Huang, MD, PhD studies the transcriptional control of neural development.
  • Guo Huang, PhD studies the cellular and molecular basis of heart regeneration from both evolutionary and developmental perspectives.

J

  • Yuh Nung Jan, PhD identifies genes involved in maintaining adult neural stem cells in mice, with the intent of defining their precise functions. His overall goal is to determine the function of adult neural stem cells in humans, in order to develop strategies to treat brain disorders including Parkinson’s disease.

K

  • Shingo Kajimura, PhD studies molecular control of adipose cell development and energy homeostasis.
  • Y.W. Kan, MBBS, DSc Control of gene expression
  • Hubert Kim, MD studies the modulation of secondary injury cascades and the application of stem cells in the treatment of traumatic injuries, particularly injury to tissues that have poor intrinsic healing.
  • Ophir Klein, MD, PhD how adult stem cells develop and how they contribute to organ renewal.
  • Sarah Knox, PhD the role of neuronal-epithelial interactions during organogenesis and regeneration
  • Scott Kogan, MD studies leukemia stem cells in mouse models and is interested in devising better therapies that target these cells.
  • Thomas Kornberg, PhD uses Drosophila to investigate mechanisms, especially cell-cell signaling, that assign cells to their developmental fates. He also directs the UCSF Tetrad Program in Genetics.
  • Arnold Kriegstein, MD, PhD is the Director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research and uses rodent models to study how embryonic neural stem and progenitor cells produce neurons. He studies developmental brain disorders such as autism and explores the application of progenitor cell grafts to the treatment of Parkinson’s disease.
  • Matthew Krummel, PhD uses in situ imaging of the proximal molecular events in the thymus to determine how signaling proceeds in the context of the tissues and organs.

L

  • Diana Laird, PhD studies the development and regulation of Primordial Germ Cells (PGCs), stem cells in the embryo that give rise to egg or sperm.
  • Lewis Lanier, PhD analyzes the regulation of T cell and NK cell immune responses by activating and inhibitory receptors.
  • Andrew Leavitt, MD studies megakaryocytopoiesis and platelet formation and the development of hematopoietic stem cells using both murine and human embryonic stem cells.
  • Janice Lee, MD, DDS is an oral and maxillofacial surgeon who studies the potential use of dental pulp stem cells as an autologous source of cells for bone repair.
  • Jae-Woo Lee, MD studies the potential therapeutic role of both adult and embryonic stem cells in acute lung injury and sepsis.  He is particularly interested in the role of microvesicles released by stem cells as one underlying mechanism.

     

  • Randall Lee, MD, PhD an adult electrophysiologist, is interested in tissue engineering approaches to target stem cell therapies to the heart including use of antibodies and biopolymers.
  • Daniel Lim, MD, PhD studies the role of chromatin remodeling factors in the regulaton of neural stem cell fate. His overall goal is to define the genetic programs and molecular mechanisms of neurogenesis in the adult brain and to translate these discoveries into cell and gene therapies for neurodegenerative diseases and injury.
  • Bernard Lo, MD is the Director of the Program in Medical Ethics at UCSF and is the Chair of the UCSF GESCR (Gamete, Embryo and Stem Cell Research) Committee. He studies the process of establishing guidelines for human research with special emphasis on genetic testing and stem cells.
  • Mignon Loh, MD uses human patient samples to better understand the pathogenesis of human leukemias with a particular focus on the role of PTPN11 mutations.
  • Jeffrey Lotz, PhD studies the use of stem cells, growth factors, and synthetic matrices for tissue engineered regeneration and healing of vertebral discs. His focus is on defining the biomechanical and inflammatory factors that cause back pain, and on cell culture and animal models of disc degeneration.
  • Clifford Lowell, MD, PhD studies the role of the Src-family and Syk tyrosine kinase in signal transduction pathways within hematopoietic cells.
  • Tom Lue, MD studies adipose tissue derived stem/progenitor cells.

M

  • Tippi MacKenzie, MD Fetal surgery was developed at UCSF over 30 years ago as a way of treating select fatal congenital anomalies.  While it has helped hundreds of children with severe anatomic disorders, it is clear that if we could develop safe and effective means of transplanting stem cells into the fetus, we could further transform this field by broadening its scope of diseases.  For example, in utero stem cell transplantation can be used to treat diseases in which stem cells are missing or mutated, such as immunodeficiencies, inborn errors of metabolism, or muscular dytrophy.  Research in our lab is focused on developing safe and effective stem cell transplantation and other therapies for fetuses with congenital anomalies.
  • Jacquelyn Maher, MD studies basic mechanisms of hepatotoxicity, with a focus on clinically relevant diseases such as drug-induced liver injury and nonalcoholic steatohepatitis (NASH).
  • Sharmila Majumdar, PhD is working on developing imaging techniques to track stem-cells in vivo.
  • Geoffrey Manley, MD, PhD works with the UCSF Brain and Spinal Injury Center (BASIC) to promote collaborative basic, translational and clinical studies on injuries to the brain and spinal cord.
  • Ralph Marcucio, PhD studies the molecular and cellular events that underlie development and regeneration of the skeleton.
  • Grayson W. Marshall, PhD studies the structure-properties relationships of calcified matrices, in particular enamel and dentin, using biophysical techniques, and evaluates how these properties change with disease.
  • Wallace Marshall, PhD Developmental biology of single cells
  • Gail Martin, PhD studies mechanisms that govern early steps of vertebrate development, thereby focusing on the role of FGF signaling in patterning and in the early stages of organ development.
  • Michael Matthay, MD is interested in stem cell treatment for acute lung injury, a major cause of acute respiratory failure characterized by pulmonary edema, inflammation, arterial hypoxemia, and the need for mechanical ventilation.
  • Frank McCormick, PhD is the Director of the UCSF Comprehensive Cancer Center and studies differences in normal and cancer cells that could be exploited for therapeutic intervention.
  • Joseph M. McCune, MD, PhD evaluates HIV-induced effects on multi-lineage hematopoiesis, as studied in the SCID-hu mice and in patient-oriented studies at the General Clinical Research Center at San Francisco General Hospital.
  • Martin McMahon, PhD investigates the ability of telomerase to immortalize human cells without promoting the loss of differentiated characteristics as an approach to the long term culture of human slets and pancreatic ductal epithelial cells.
  • Michael McManus, PhD studies biological processes relating to RNA interference pathways, using the mouse as a model. This includes the study of small regulatory RNAs of biological significance that regulate development in mammals.
  • Synthia Mellon, PhD studies neural development and steroidogenesis.
  • Theodore Miclau, MD studies cellular molecular mechanisms of fracture repair, particularly related to the roles of inflammation, angiogenesis, and mechanical influences on healing. He has developed models of mandibular and tibial fracture repair.
  • Takashi Mikawa, PhD studies development of the cardiac conduction system during early embryogenesis and the signals that distinguish conduction cells from working myocytes using the chick system.
  • Anna Molofsky MD, PhD studies the role of glial cells, particularly astrocytes, in neural circuit development and in psychiatric diseases.

N

  • Sarah Nelson, PhD focuses on the development of techniques for acquisition, reconstructing and quantitative analysis of imaging and spectral data.
  • Robert Nissenson, PhD studies the role of signaling pathways in the development of bone depositing osteoblasts.
  • Linda Noble, PhD studies oxidative stress and neurogenesis.
  • Todd Nystul, PhD studies epithelial stem cells and their associated niche in the Drosophila ovary.