Jeffrey Bush, PhD

Core

Although craniofacial anomalies are among the most common congenital defects in humans, the underlying etiology is incompletely understood. By integrating mouse genetic approaches with proteomics, biochemistry, and cell biology, the Bush lab investigates the signaling mechanisms that coordinate craniofacial morphogenesis and how this signaling control is disrupted in congenital craniofacial disease. One focus of the lab is Eph/ephrin signaling, a family of signaling molecules that regulates multiple aspects of craniofacial development.