Daniel Bikle, MD, PhD

Affiliated

In pursuing our studies we make extensive use of genetically modified mice. For the skeletal projects we conditionally delete IGF-I or its receptor, IGF-IR, from chondrocytes, osteoblasts and osteoclasts then ask how that affects skeletal development, response to PTH, response to skeletal unloading or reloading, and fracture healing. In the studies of skin we use mice lacking the vitamin D receptor (VDR), VDR coactivators such as MED1 and SRC3, the enzyme producing the active vitamin D metabolite, 1,25(OH)2D (CYP27B1), the calcium receptor, or key components in the hedgehog and wnt/beta-catenin pathways to examine the impact of such gene deletions on epidermal development, hair follicle cycling, and UVB induced tumor formation.