Rosemary Akhurst, PhD

Core

Components of the TGF-β signaling pathway are essential in stem cell maintenance and lineage specification of both embryonic, adult and cancer stem cells. The Akhurst lab is undertaking a functional dissection of genetic loci, Tgfbm1, Tgfbm2 and Tgfbm3, that modify biological responses to TGF-β1 during angiogenesis and vascular remodeling. We hypothesize that Tgfbm loci regulate the ability of haematopoietic stem and endothelial progenitor cells to mobilize from the bone marrow and a) to home to sites of vascular injury during tissue repair, and b) to home to the pre-metastatic niche during tumorigenesis.