Andrei Goga, MD, PhD
Andrei Goga, MD, PhD
Oncogenes and Cell Cycle Control
Tumor cells are driven to proliferate by oncogene over-expression or the loss of tumor-suppressor genes. Since tumor cells develop a deregulated cell cycle, their proliferation may be especially sensitive to cell cycle inhibitors. Cell cycle regulation has been extensively studied in simple model organisms such as yeast and in mammalian cell culture systems, however, much less is known about cell cycle regulation in the context of a whole mouse or in a developing tumor. We seek to develop mouse model systems to study basic cell cycle regulation in normal and tumor cells and to facilitate the development of cell cycle inhibitors as therapeutics.
Selected Publications
Goga, A., McLaughlin, J., Pendergast, A.M., Parmar, K., Muller, A., Rosenberg, N., and Witte, O.N. 1993. Oncogenic activation of c-ABL by mutation within its last exon. Mol. Cell Biol. 13:4967-4975.
Goga, A., Liu, X., Hambuch, T., Senechal, K., Major, E., Berk, A.J., Witte, O.N., and Sawyers, C.L. 1995. p53 dependent growth suppression by the c-ABL nuclear tyrosine kinase . Oncogene 11: 791-799.
